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B8DSX7

- THIM_BIFA0

UniProt

B8DSX7 - THIM_BIFA0

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Protein
Hydroxyethylthiazole kinase
Gene
thiM, BLA_0814
Organism
Bifidobacterium animalis subsp. lactis (strain AD011)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei67 – 671Substrate; via amide nitrogen By similarity
Binding sitei142 – 1421ATP By similarity
Binding sitei206 – 2061ATP By similarity
Binding sitei233 – 2331Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBANI442563:GHG0-809-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:BLA_0814
OrganismiBifidobacterium animalis subsp. lactis (strain AD011)
Taxonomic identifieri442563 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000002456: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Hydroxyethylthiazole kinaseUniRule annotation
PRO_0000383822Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi442563.BLA_0814.

Structurei

3D structure databases

ProteinModelPortaliB8DSX7.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiNACTQLA.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

B8DSX7-1 [UniParc]FASTAAdd to Basket

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MTTASTTPNS DTSNLHEVAP DDPIRERIRQ AAQNVREQTP LAQSFTNFVT    50
INLVANAQLA AGGTAAMSFL PNDVTSLASS CGATYINVGT LLPFYRDALQ 100
EISEHLSRHG CKWVLDPVAA GVGVARTEIL KGFKDYPPTV IRANASEALV 150
LHDMWQLGDA AGTDEHNGPA GVEAADSVDA AITAATDLAA YLALHSPTHT 200
GAVAVSGEVD LVTDGRLVYR LPGGSAMMTK ITGAGCSLGG VTATYLAVAD 250
ALVASLAASM LYNVSSGAAE RASHGPGSFQ TAFLDALWNV TPEEIASAPL 300
YLA 303
Length:303
Mass (Da):31,354
Last modified:March 3, 2009 - v1
Checksum:i3C89F1F5D4BA0A97
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001213 Genomic DNA. Translation: ACL29106.1.
RefSeqiYP_002469682.1. NC_011835.1.

Genome annotation databases

EnsemblBacteriaiACL29106; ACL29106; BLA_0814.
GeneIDi7264221.
KEGGibla:BLA_0814.
PATRICi21104533. VBIBifAni98964_0848.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001213 Genomic DNA. Translation: ACL29106.1 .
RefSeqi YP_002469682.1. NC_011835.1.

3D structure databases

ProteinModelPortali B8DSX7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 442563.BLA_0814.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL29106 ; ACL29106 ; BLA_0814 .
GeneIDi 7264221.
KEGGi bla:BLA_0814.
PATRICi 21104533. VBIBifAni98964_0848.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi NACTQLA.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci BANI442563:GHG0-809-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011."
    Kim J.F., Jeong H., Yu D.S., Choi S.-H., Hur C.-G., Park M.-S., Yoon S.H., Kim D.-W., Ji G.E., Park H.-S., Oh T.K.
    J. Bacteriol. 191:678-679(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AD011.

Entry informationi

Entry nameiTHIM_BIFA0
AccessioniPrimary (citable) accession number: B8DSX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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