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B8DSX7

- THIM_BIFA0

UniProt

B8DSX7 - THIM_BIFA0

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Bifidobacterium animalis subsp. lactis (strain AD011)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei67 – 671Substrate; via amide nitrogenUniRule annotation
    Binding sitei142 – 1421ATPUniRule annotation
    Binding sitei206 – 2061ATPUniRule annotation
    Binding sitei233 – 2331Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBANI442563:GHG0-809-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:BLA_0814
    OrganismiBifidobacterium animalis subsp. lactis (strain AD011)
    Taxonomic identifieri442563 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000002456: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303Hydroxyethylthiazole kinasePRO_0000383822Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi442563.BLA_0814.

    Structurei

    3D structure databases

    ProteinModelPortaliB8DSX7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiNACTQLA.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8DSX7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTASTTPNS DTSNLHEVAP DDPIRERIRQ AAQNVREQTP LAQSFTNFVT    50
    INLVANAQLA AGGTAAMSFL PNDVTSLASS CGATYINVGT LLPFYRDALQ 100
    EISEHLSRHG CKWVLDPVAA GVGVARTEIL KGFKDYPPTV IRANASEALV 150
    LHDMWQLGDA AGTDEHNGPA GVEAADSVDA AITAATDLAA YLALHSPTHT 200
    GAVAVSGEVD LVTDGRLVYR LPGGSAMMTK ITGAGCSLGG VTATYLAVAD 250
    ALVASLAASM LYNVSSGAAE RASHGPGSFQ TAFLDALWNV TPEEIASAPL 300
    YLA 303
    Length:303
    Mass (Da):31,354
    Last modified:March 3, 2009 - v1
    Checksum:i3C89F1F5D4BA0A97
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001213 Genomic DNA. Translation: ACL29106.1.
    RefSeqiYP_002469682.1. NC_011835.1.

    Genome annotation databases

    EnsemblBacteriaiACL29106; ACL29106; BLA_0814.
    GeneIDi7264221.
    KEGGibla:BLA_0814.
    PATRICi21104533. VBIBifAni98964_0848.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001213 Genomic DNA. Translation: ACL29106.1 .
    RefSeqi YP_002469682.1. NC_011835.1.

    3D structure databases

    ProteinModelPortali B8DSX7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 442563.BLA_0814.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL29106 ; ACL29106 ; BLA_0814 .
    GeneIDi 7264221.
    KEGGi bla:BLA_0814.
    PATRICi 21104533. VBIBifAni98964_0848.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi NACTQLA.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci BANI442563:GHG0-809-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011."
      Kim J.F., Jeong H., Yu D.S., Choi S.-H., Hur C.-G., Park M.-S., Yoon S.H., Kim D.-W., Ji G.E., Park H.-S., Oh T.K.
      J. Bacteriol. 191:678-679(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AD011.

    Entry informationi

    Entry nameiTHIM_BIFA0
    AccessioniPrimary (citable) accession number: B8DSX7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3