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B8DSX7 (THIM_BIFA0) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:BLA_0814
OrganismBifidobacterium animalis subsp. lactis (strain AD011) [Complete proteome] [HAMAP]
Taxonomic identifier442563 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 303303Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383822

Sites

Binding site671Substrate; via amide nitrogen By similarity
Binding site1421ATP By similarity
Binding site2061ATP By similarity
Binding site2331Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
B8DSX7 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 3C89F1F5D4BA0A97

FASTA30331,354
        10         20         30         40         50         60 
MTTASTTPNS DTSNLHEVAP DDPIRERIRQ AAQNVREQTP LAQSFTNFVT INLVANAQLA 

        70         80         90        100        110        120 
AGGTAAMSFL PNDVTSLASS CGATYINVGT LLPFYRDALQ EISEHLSRHG CKWVLDPVAA 

       130        140        150        160        170        180 
GVGVARTEIL KGFKDYPPTV IRANASEALV LHDMWQLGDA AGTDEHNGPA GVEAADSVDA 

       190        200        210        220        230        240 
AITAATDLAA YLALHSPTHT GAVAVSGEVD LVTDGRLVYR LPGGSAMMTK ITGAGCSLGG 

       250        260        270        280        290        300 
VTATYLAVAD ALVASLAASM LYNVSSGAAE RASHGPGSFQ TAFLDALWNV TPEEIASAPL 


YLA 

« Hide

References

[1]"Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011."
Kim J.F., Jeong H., Yu D.S., Choi S.-H., Hur C.-G., Park M.-S., Yoon S.H., Kim D.-W., Ji G.E., Park H.-S., Oh T.K.
J. Bacteriol. 191:678-679(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AD011.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001213 Genomic DNA. Translation: ACL29106.1.
RefSeqYP_002469682.1. NC_011835.1.

3D structure databases

ProteinModelPortalB8DSX7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING442563.BLA_0814.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL29106; ACL29106; BLA_0814.
GeneID7264221.
KEGGbla:BLA_0814.
PATRIC21104533. VBIBifAni98964_0848.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMASPVMAHA.
OrthoDBEOG628F8M.
ProtClustDBCLSK572499.

Enzyme and pathway databases

BioCycBANI442563:GHG0-809-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PRINTSPR01099. HYETHTZKNASE.
ProtoNetSearch...

Entry information

Entry nameTHIM_BIFA0
AccessionPrimary (citable) accession number: B8DSX7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways