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B8DR41 (SAHH_DESVM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosylhomocysteinase
EC=3.3.1.1
Alternative name(s):
S-adenosyl-L-homocysteine hydrolase
Short name=AdoHcyase
Gene names
Name:ahcY
Ordered Locus Names:DvMF_2580
OrganismDesulfovibrio vulgaris (strain Miyazaki F / DSM 19637) [Complete proteome] [HAMAP]
Taxonomic identifier883 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio

Protein attributes

Sequence length479 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine By similarity. HAMAP MF_00563

Catalytic activity

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. HAMAP MF_00563

Cofactor

Binds 1 NAD per subunit By similarity. HAMAP MF_00563

Pathway

Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. HAMAP MF_00563

Subcellular location

Cytoplasm By similarity HAMAP MF_00563.

Sequence similarities

Belongs to the adenosylhomocysteinase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processone-carbon metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionadenosylhomocysteinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 479479Adenosylhomocysteinase HAMAP MF_00563
PRO_1000129283

Regions

Nucleotide binding204 – 2063NAD By similarity
Nucleotide binding267 – 2726NAD By similarity
Nucleotide binding346 – 3483NAD By similarity

Sites

Binding site661Substrate By similarity
Binding site1421Substrate By similarity
Binding site2031Substrate By similarity
Binding site2331Substrate By similarity
Binding site2371Substrate By similarity
Binding site2381NAD By similarity
Binding site2901NAD By similarity
Binding site3251NAD By similarity
Binding site3941NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
B8DR41 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: E802BD6035E15FAC

FASTA47952,824
        10         20         30         40         50         60 
MTDAKRAQAL DLSLANKVAD MALADFGHKE MQLSEREVPG LMELIRMYGV SKPLKGLRVT 

        70         80         90        100        110        120 
GSLHMTIQTA MLIKTLYELG ADIRWASCNI FSTQDHAAAA IADSGMAKVF AWKGETLEDY 

       130        140        150        160        170        180 
WWCTEMALTW PDGSGPDLLV DDGGDATLMI HKGVEVENNP ELLKQAYDNK EFQIIMDRLA 

       190        200        210        220        230        240 
LAYQNDPGRW QRVAARVRGV SEETTTGVHR LYQLEQEGKL LFPAINVNDS VTKSKFDNLY 

       250        260        270        280        290        300 
GCRESLADGI KRATDVMVAG KVVVVAGYGD VGKGCAQSMR GFGARVLVTE IDPICALQAA 

       310        320        330        340        350        360 
MEGYEVTTME KAVEEGDIFV TATGNYKVIT GEHMEAMKDE AIVCNIGHFD NEIDMHYLET 

       370        380        390        400        410        420 
TPGCTCLNIK PQVDKWTLKS GRSIIVLAEG RLVNLGCATG HPSFVMSNSF TNQTLAQIEL 

       430        440        450        460        470 
ATNPDLERKV YILPKKLDEQ VARLHLARLG VTLTTLTKEQ ADYIGVPVDG PYKPGHYRY

« Hide

References

[1]"Complete sequence of Desulfovibrio vulgaris str. 'Miyazaki F'."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Hazen T.C., Richardson P.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Miyazaki F / DSM 19637.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001197 Genomic DNA. Translation: ACL09519.1.
RefSeqYP_002436987.1. NC_011769.1.

3D structure databases

ProteinModelPortalB8DR41.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8DR41.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7174517.
GenomeReviewsGene locus DvMF_2580 in contig CP001197_GR.
KEGGdvm:DvMF_2580.
PATRIC21775594. VBIDesVul86729_2798.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG352029.
OMASAQVWVT.
ProtClustDBPRK05476.

Family and domain databases

HAMAPMF_00563. AdoHcyase.
[Tree]
InterProIPR000043. Adenosylhomocysteinase.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
[Graphical view]
KOK01251.
PANTHERPTHR23420. Ad_hcy_hydrolase. 1 hit.
PfamPF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
[Graphical view]
PIRSFPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTSM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
[Graphical view]
TIGRFAMsTIGR00936. AhcY. 1 hit.
PROSITEPS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSAHH_DESVM
AccessionPrimary (citable) accession number: B8DR41
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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