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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciDVUL883:G1GTY-236-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:DvMF_0224
OrganismiDesulfovibrio vulgaris (strain Miyazaki F / DSM 19637)
Taxonomic identifieri883 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000001361 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001324781 – 443Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST443

Proteomic databases

PRIDEiB8DP96

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi883.DvMF_0224

Structurei

3D structure databases

ProteinModelPortaliB8DP96
SMRiB8DP96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

B8DP96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFIPHSPEE VREMLSVIGV QSIEDLFVDI PAEMRPRSFE LPLGLSEMQV
60 70 80 90 100
LAKMEEMAAR NRTDVVSFLG GGFYSHHIPA AVDALVSRGE FYTAYTPYQP
110 120 130 140 150
EASQGTLQAI FEYQTAVCRL LDMDCANASV YDGGSAIFEA MMMAVRATKR
160 170 180 190 200
RKLVIDEAVS PIWRTMLASY TSNLSLDLVT VPQVDGRSDM AAMKAAVDTG
210 220 230 240 250
CAAVVVQNPN FFGVVEDFTD LFAHAKSQKA ASVISVYPVM QSVLKTPGEM
260 270 280 290 300
GADIAVAEGQ SLGQPLSFGG PYLGIMTCTK DMVRQMPGRI VGRTNDTEGR
310 320 330 340 350
TGYVLTLQAR EQHIRRAKAT SNICSNQALC ALRTLVHLCL LGPEGLIRTA
360 370 380 390 400
ELSMERARYA MERLTAIAGV RPLNTAPFGN EFAVRLPIPA FEAVDRLTAR
410 420 430 440
GYVPGFPVGR YYAGMDDVLL VACTEKNSFE QVGILAEMLG GIL
Length:443
Mass (Da):48,205
Last modified:March 3, 2009 - v1
Checksum:i0E9B0C70A1C94CA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001197 Genomic DNA Translation: ACL07183.1
RefSeqiWP_012611377.1, NC_011769.1

Genome annotation databases

EnsemblBacteriaiACL07183; ACL07183; DvMF_0224
KEGGidvm:DvMF_0224

Similar proteinsi

Entry informationi

Entry nameiGCSPA_DESVM
AccessioniPrimary (citable) accession number: B8DP96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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