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B8DN64

- ASSY_DESVM

UniProt

B8DN64 - ASSY_DESVM

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Protein
Argininosuccinate synthase
Gene
argG, DvMF_0047
Organism
Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei89 – 891Citrulline By similarity
Binding sitei94 – 941Citrulline By similarity
Binding sitei119 – 1191ATP; via amide nitrogen By similarity
Binding sitei121 – 1211Aspartate By similarity
Binding sitei125 – 1251Aspartate By similarity
Binding sitei125 – 1251Citrulline By similarity
Binding sitei126 – 1261Aspartate By similarity
Binding sitei129 – 1291Citrulline By similarity
Binding sitei177 – 1771Citrulline By similarity
Binding sitei186 – 1861Citrulline By similarity
Binding sitei262 – 2621Citrulline By similarity
Binding sitei274 – 2741Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 199ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDVUL883:GCJ5-53-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:DvMF_0047
OrganismiDesulfovibrio vulgaris (strain Miyazaki F / DSM 19637)
Taxonomic identifieri883 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000001361: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Argininosuccinate synthaseUniRule annotation
PRO_1000116191Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi883.DvMF_0047.

Structurei

3D structure databases

ProteinModelPortaliB8DN64.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiVEEYIWR.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8DN64-1 [UniParc]FASTAAdd to Basket

« Hide

MAKAIKKVVL AYSGGLDTSV ILKWIAVTYG CEVVTLTADL GQEEDLDGVD    50
AKALRTGASR AYVEDLREEF ARDFIFPMMR SGAVYEGRYL LGTSIARPLI 100
AKRLVDIARA EGAQAVAHGA TGKGNDQVRF ELAVNALAPD LDVIAPWRIW 150
DLRSRTDLTA FAEQHGIPLS TSSKQYSMDR NMLHCSFEGG ELEDPWCEPG 200
PNSHVMAVPV EQAPDTPEYI TIEFKKGDAV AVNGEAMSPA SIIRTLNTIG 250
GRHGIGRLDM VENRFVGIKS RGVYETPGGT VLHIAHRDLE GICMDRESMH 300
LRDQLIPRYS EAVYNGFWFA PEREAMQAFI DKTQETVNGT VRLKLYKGNA 350
YPVGRTSPNT LYCHDLATFE DCATYDHADA AGFIKLQGLR VRGYAQRVKK 400
D 401
Length:401
Mass (Da):44,292
Last modified:March 3, 2009 - v1
Checksum:iD3FCA6D2A6EFD532
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001197 Genomic DNA. Translation: ACL07008.1.
RefSeqiYP_002434476.1. NC_011769.1.

Genome annotation databases

EnsemblBacteriaiACL07008; ACL07008; DvMF_0047.
GeneIDi7171920.
KEGGidvm:DvMF_0047.
PATRICi21769981. VBIDesVul86729_0053.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001197 Genomic DNA. Translation: ACL07008.1 .
RefSeqi YP_002434476.1. NC_011769.1.

3D structure databases

ProteinModelPortali B8DN64.
ModBasei Search...

Protein-protein interaction databases

STRINGi 883.DvMF_0047.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL07008 ; ACL07008 ; DvMF_0047 .
GeneIDi 7171920.
KEGGi dvm:DvMF_0047.
PATRICi 21769981. VBIDesVul86729_0053.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi VEEYIWR.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci DVUL883:GCJ5-53-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Desulfovibrio vulgaris str. 'Miyazaki F'."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Hazen T.C., Richardson P.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Miyazaki F / DSM 19637.

Entry informationi

Entry nameiASSY_DESVM
AccessioniPrimary (citable) accession number: B8DN64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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