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B8DKV9 (NADK_DESVM) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:DvMF_0581
OrganismDesulfovibrio vulgaris (strain Miyazaki F / DSM 19637) [Complete proteome] [HAMAP]
Taxonomic identifier883 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283NAD kinase HAMAP-Rule MF_00361
PRO_1000120851

Regions

Nucleotide binding65 – 662NAD By similarity
Nucleotide binding139 – 1402NAD By similarity
Nucleotide binding180 – 1856NAD By similarity

Sites

Active site651Proton acceptor By similarity
Binding site1501NAD By similarity
Binding site1671NAD By similarity
Binding site1691NAD By similarity
Binding site2391NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
B8DKV9 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: E708E8E4FF051F8F

FASTA28330,077
        10         20         30         40         50         60 
MHTALRSILI VTKSGHREAE ALGERMRAWL AARGLSARVV ENTGDAVSLA VAGQECSLAL 

        70         80         90        100        110        120 
VLGGDGTILG VARRLLGSGV PLLGVNLGKV GFLAEVAATR WESSLERLLS GGVTVQERLA 

       130        140        150        160        170        180 
LSFRVERDGA TVHSGGAVND VVINRGILAR VINLDLRVGS ERLGELRADG LIVSTPTGAT 

       190        200        210        220        230        240 
GYSVSARGPL VHPQLHVYTV TPICPFLNNL LPLVLPGEAR LSVTVRDRTN EVYLTQDGQE 

       250        260        270        280 
GYALQAGDVV HVERAPGGML FATIEELSYY RKLKAKGFIK DQA 

« Hide

References

[1]"Complete sequence of Desulfovibrio vulgaris str. 'Miyazaki F'."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Hazen T.C., Richardson P.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Miyazaki F / DSM 19637.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001197 Genomic DNA. Translation: ACL07538.1.
RefSeqYP_002435006.1. NC_011769.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING883.DvMF_0581.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL07538; ACL07538; DvMF_0581.
GeneID7172468.
KEGGdvm:DvMF_0581.
PATRIC21771123. VBIDesVul86729_0612.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227222.
KOK00858.
OMAICPFLNN.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycDVUL883:GCJ5-602-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_DESVM
AccessionPrimary (citable) accession number: B8DKV9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: July 9, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families