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B8DKP2 (PHNX_DESVM) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphonoacetaldehyde hydrolase

Short name=Phosphonatase
EC=3.11.1.1
Alternative name(s):
Phosphonoacetaldehyde phosphonohydrolase
Gene names
Name:phnX
Ordered Locus Names:DvMF_0514
OrganismDesulfovibrio vulgaris (strain Miyazaki F / DSM 19637) [Complete proteome] [HAMAP]
Taxonomic identifier883 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in phosphonate degradation By similarity. HAMAP-Rule MF_01375

Catalytic activity

Phosphonoacetaldehyde + H2O = acetaldehyde + phosphate. HAMAP-Rule MF_01375

Cofactor

Binds 1 Mg2+ ion per subunit By similarity. HAMAP-Rule MF_01375

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01375

Sequence similarities

Belongs to the HAD-like hydrolase superfamily. PhnX family.

Ontologies

Keywords
   LigandMagnesium
Metal-binding
Schiff base
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processorganic phosphonate catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

phosphonoacetaldehyde hydrolase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 280280Phosphonoacetaldehyde hydrolase HAMAP-Rule MF_01375
PRO_1000144832

Sites

Active site201Nucleophile By similarity
Active site611Schiff-base intermediate with substrate By similarity
Metal binding201Magnesium By similarity
Metal binding221Magnesium; via carbonyl oxygen By similarity
Metal binding1941Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
B8DKP2 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 102D065062AACB1E

FASTA28030,244
        10         20         30         40         50         60 
MKPFLRTRVY DGPVRAVVLD WAGTAVDHGC LGPAAVFVQA FALHGVEVAV SEAREPMGSE 

        70         80         90        100        110        120 
KREHVRRMLA MDSVAARWRA VHGHVPHEAD VDAVYRDVEP LMLQTIAAHA VPVPGLAEFV 

       130        140        150        160        170        180 
DRVRGRGMGL GSCTGYTGPM MEVLVPEAAR RGYSPDVVVH ASEVPAGRPY PWMCYLNAMR 

       190        200        210        220        230        240 
LGVHPMESMV KIGDTVADMH EARNAGMWTV GVVRTGNDVG LSEVDAARMP PDQLAARMTV 

       250        260        270        280 
AAARLREAGA HYVVDSIADC FSVIKAIEAR LARGDTPYPA 

« Hide

References

[1]"Complete sequence of Desulfovibrio vulgaris str. 'Miyazaki F'."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Hazen T.C., Richardson P.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Miyazaki F / DSM 19637.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001197 Genomic DNA. Translation: ACL07471.1.
RefSeqYP_002434939.1. NC_011769.1.

3D structure databases

ProteinModelPortalB8DKP2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING883.DvMF_0514.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL07471; ACL07471; DvMF_0514.
GeneID7172401.
KEGGdvm:DvMF_0514.
PATRIC21770981. VBIDesVul86729_0541.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0637.
HOGENOMHOG000217971.
KOK05306.
OMAFDWAGTM.
OrthoDBEOG6ZH2FH.
ProtClustDBPRK13478.

Enzyme and pathway databases

BioCycDVUL883:GCJ5-534-MONOMER.

Family and domain databases

Gene3D1.10.150.240. 1 hit.
3.40.50.1000. 2 hits.
HAMAPMF_01375. PhnX.
InterProIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
IPR006323. Phosphonoacetald_hydro.
[Graphical view]
PfamPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 1 hit.
TIGRFAMsTIGR01549. HAD-SF-IA-v1. 1 hit.
TIGR01422. phosphonatase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePHNX_DESVM
AccessionPrimary (citable) accession number: B8DKP2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families