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B8DKP2

- PHNX_DESVM

UniProt

B8DKP2 - PHNX_DESVM

Protein

Phosphonoacetaldehyde hydrolase

Gene

phnX

Organism
Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Involved in phosphonate degradation.UniRule annotation

    Catalytic activityi

    Phosphonoacetaldehyde + H2O = acetaldehyde + phosphate.UniRule annotation

    Cofactori

    Binds 1 Mg2+ ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei20 – 201NucleophileUniRule annotation
    Metal bindingi20 – 201MagnesiumUniRule annotation
    Metal bindingi22 – 221Magnesium; via carbonyl oxygenUniRule annotation
    Active sitei61 – 611Schiff-base intermediate with substrateUniRule annotation
    Metal bindingi194 – 1941MagnesiumUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphonoacetaldehyde hydrolase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. organic phosphonate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium, Metal-binding, Schiff base

    Enzyme and pathway databases

    BioCyciDVUL883:GCJ5-534-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphonoacetaldehyde hydrolaseUniRule annotation (EC:3.11.1.1UniRule annotation)
    Short name:
    PhosphonataseUniRule annotation
    Alternative name(s):
    Phosphonoacetaldehyde phosphonohydrolaseUniRule annotation
    Gene namesi
    Name:phnXUniRule annotation
    Ordered Locus Names:DvMF_0514
    OrganismiDesulfovibrio vulgaris (strain Miyazaki F / DSM 19637)
    Taxonomic identifieri883 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
    ProteomesiUP000001361: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 280280Phosphonoacetaldehyde hydrolasePRO_1000144832Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi883.DvMF_0514.

    Structurei

    3D structure databases

    ProteinModelPortaliB8DKP2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HAD-like hydrolase superfamily. PhnX family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0637.
    HOGENOMiHOG000217971.
    KOiK05306.
    OMAiDERNVER.
    OrthoDBiEOG6ZH2FH.

    Family and domain databases

    Gene3Di1.10.150.240. 1 hit.
    3.40.50.1000. 2 hits.
    HAMAPiMF_01375. PhnX.
    InterProiIPR023214. HAD-like_dom.
    IPR006439. HAD-SF_hydro_IA.
    IPR023198. PGP_dom2.
    IPR006323. Phosphonoacetald_hydro.
    [Graphical view]
    PfamiPF13419. HAD_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01549. HAD-SF-IA-v1. 1 hit.
    TIGR01422. phosphonatase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8DKP2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPFLRTRVY DGPVRAVVLD WAGTAVDHGC LGPAAVFVQA FALHGVEVAV    50
    SEAREPMGSE KREHVRRMLA MDSVAARWRA VHGHVPHEAD VDAVYRDVEP 100
    LMLQTIAAHA VPVPGLAEFV DRVRGRGMGL GSCTGYTGPM MEVLVPEAAR 150
    RGYSPDVVVH ASEVPAGRPY PWMCYLNAMR LGVHPMESMV KIGDTVADMH 200
    EARNAGMWTV GVVRTGNDVG LSEVDAARMP PDQLAARMTV AAARLREAGA 250
    HYVVDSIADC FSVIKAIEAR LARGDTPYPA 280
    Length:280
    Mass (Da):30,244
    Last modified:March 3, 2009 - v1
    Checksum:i102D065062AACB1E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001197 Genomic DNA. Translation: ACL07471.1.
    RefSeqiWP_012611663.1. NC_011769.1.
    YP_002434939.1. NC_011769.1.

    Genome annotation databases

    EnsemblBacteriaiACL07471; ACL07471; DvMF_0514.
    GeneIDi7172401.
    KEGGidvm:DvMF_0514.
    PATRICi21770981. VBIDesVul86729_0541.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001197 Genomic DNA. Translation: ACL07471.1 .
    RefSeqi WP_012611663.1. NC_011769.1.
    YP_002434939.1. NC_011769.1.

    3D structure databases

    ProteinModelPortali B8DKP2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 883.DvMF_0514.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL07471 ; ACL07471 ; DvMF_0514 .
    GeneIDi 7172401.
    KEGGi dvm:DvMF_0514.
    PATRICi 21770981. VBIDesVul86729_0541.

    Phylogenomic databases

    eggNOGi COG0637.
    HOGENOMi HOG000217971.
    KOi K05306.
    OMAi DERNVER.
    OrthoDBi EOG6ZH2FH.

    Enzyme and pathway databases

    BioCyci DVUL883:GCJ5-534-MONOMER.

    Family and domain databases

    Gene3Di 1.10.150.240. 1 hit.
    3.40.50.1000. 2 hits.
    HAMAPi MF_01375. PhnX.
    InterProi IPR023214. HAD-like_dom.
    IPR006439. HAD-SF_hydro_IA.
    IPR023198. PGP_dom2.
    IPR006323. Phosphonoacetald_hydro.
    [Graphical view ]
    Pfami PF13419. HAD_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01549. HAD-SF-IA-v1. 1 hit.
    TIGR01422. phosphonatase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Desulfovibrio vulgaris str. 'Miyazaki F'."
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Hazen T.C., Richardson P.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Miyazaki F / DSM 19637.

    Entry informationi

    Entry nameiPHNX_DESVM
    AccessioniPrimary (citable) accession number: B8DKP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3