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B8DJF0

- SYL_DESVM

UniProt

B8DJF0 - SYL_DESVM

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei589 – 5891ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDVUL883:GCJ5-3170-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:DvMF_3090
    OrganismiDesulfovibrio vulgaris (strain Miyazaki F / DSM 19637)
    Taxonomic identifieri883 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
    ProteomesiUP000001361: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 834834Leucine--tRNA ligasePRO_1000199197Add
    BLAST

    Proteomic databases

    PRIDEiB8DJF0.

    Interactioni

    Protein-protein interaction databases

    STRINGi883.DvMF_3090.

    Structurei

    3D structure databases

    ProteinModelPortaliB8DJF0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5011"HIGH" regionAdd
    BLAST
    Motifi586 – 5905"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiVVHCDAC.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8DJF0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYDHQSIEI KWQRTWEESG AFHCDHHSDK PKYYVLEMFP YPSGNIHMGH    50
    VRNYSIGDVV ARFKRMQGFN VLHPMGWDAF GLPAENAAIK HGTHPAKWTF 100
    SNIDNMRTQL RRLGYSYDWR RELATCTPEY YRWEQQFFLR FFEKGLVYRK 150
    QAPQNWCPKC HTVLANEQVI EGLCWRCDSA VEQKNLTQWF LRITDYAEEL 200
    LADLDKLEAG WPERVVSMQR NWIGKSIGAE IVFPLEGPGG SGNDDSITVF 250
    TTRQDTVFGA TFMSLAPEHP LVEQLIDGKP EAPAVRAFVE RIRNMDRIVR 300
    QSDDLEKEGV FTGAYCVNPF TGRRMPIWVA NFVLAEYGTG AVMAVPAHDQ 350
    RDFEFARKYD LPMQVVIQPE GDALDTAAMQ AAWTEAGLLV NSGEFDGLPN 400
    EAAKQKIADS LETSGKGRRT VNYRLRDWNI SRQRYWGAPI PVVYCDACGV 450
    VAEKDENLPV LLPLEVRTHE DGRSPLPDTP EFAECACPKC GGKARRETDT 500
    MDTFVESSWY FARYTSASKD DGAFDPAALK YWMPVDQYIG GVEHAILHLL 550
    YSRFFVKALR DCGYMDLDEP FANLLTQGMV LKEGAKMSKS KGNVVDPTEM 600
    IARYGADTVR LFCLFAAPPE RDFDWSDSGI EGSYRFIGRI WRLAEELSGV 650
    LLPVKACSAT AADAATPQGK DLRNKEHATV RKAGADISDR FQFNTAIAAV 700
    MELVNALYLA KDELSGDEGG RKVLSSAVAT VLTLLSPITP HIAEELWASI 750
    GNAGRITDEP WPQWSEEALA RDEETIVVQI NGKLRGRVSV PAGADAKAIE 800
    AAALSEPNVA RHLEDVTVRK VVVIPGKLVN VVVG 834
    Length:834
    Mass (Da):93,505
    Last modified:March 3, 2009 - v1
    Checksum:iF3DE26FD5DD02836
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001197 Genomic DNA. Translation: ACL10027.1.
    RefSeqiYP_002437495.1. NC_011769.1.

    Genome annotation databases

    EnsemblBacteriaiACL10027; ACL10027; DvMF_3090.
    GeneIDi7175036.
    KEGGidvm:DvMF_3090.
    PATRICi21776719. VBIDesVul86729_3352.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001197 Genomic DNA. Translation: ACL10027.1 .
    RefSeqi YP_002437495.1. NC_011769.1.

    3D structure databases

    ProteinModelPortali B8DJF0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 883.DvMF_3090.

    Proteomic databases

    PRIDEi B8DJF0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL10027 ; ACL10027 ; DvMF_3090 .
    GeneIDi 7175036.
    KEGGi dvm:DvMF_3090.
    PATRICi 21776719. VBIDesVul86729_3352.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi VVHCDAC.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci DVUL883:GCJ5-3170-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Desulfovibrio vulgaris str. 'Miyazaki F'."
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Hazen T.C., Richardson P.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Miyazaki F / DSM 19637.

    Entry informationi

    Entry nameiSYL_DESVM
    AccessioniPrimary (citable) accession number: B8DJF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3