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B8DJF0

- SYL_DESVM

UniProt

B8DJF0 - SYL_DESVM

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Desulfovibrio vulgaris (strain Miyazaki F / DSM 19637)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei589 – 5891ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDVUL883:GCJ5-3170-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:DvMF_3090
OrganismiDesulfovibrio vulgaris (strain Miyazaki F / DSM 19637)
Taxonomic identifieri883 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000001361: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 834834Leucine--tRNA ligasePRO_1000199197Add
BLAST

Proteomic databases

PRIDEiB8DJF0.

Interactioni

Protein-protein interaction databases

STRINGi883.DvMF_3090.

Structurei

3D structure databases

ProteinModelPortaliB8DJF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" regionAdd
BLAST
Motifi586 – 5905"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiVVHCDAC.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8DJF0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYDHQSIEI KWQRTWEESG AFHCDHHSDK PKYYVLEMFP YPSGNIHMGH
60 70 80 90 100
VRNYSIGDVV ARFKRMQGFN VLHPMGWDAF GLPAENAAIK HGTHPAKWTF
110 120 130 140 150
SNIDNMRTQL RRLGYSYDWR RELATCTPEY YRWEQQFFLR FFEKGLVYRK
160 170 180 190 200
QAPQNWCPKC HTVLANEQVI EGLCWRCDSA VEQKNLTQWF LRITDYAEEL
210 220 230 240 250
LADLDKLEAG WPERVVSMQR NWIGKSIGAE IVFPLEGPGG SGNDDSITVF
260 270 280 290 300
TTRQDTVFGA TFMSLAPEHP LVEQLIDGKP EAPAVRAFVE RIRNMDRIVR
310 320 330 340 350
QSDDLEKEGV FTGAYCVNPF TGRRMPIWVA NFVLAEYGTG AVMAVPAHDQ
360 370 380 390 400
RDFEFARKYD LPMQVVIQPE GDALDTAAMQ AAWTEAGLLV NSGEFDGLPN
410 420 430 440 450
EAAKQKIADS LETSGKGRRT VNYRLRDWNI SRQRYWGAPI PVVYCDACGV
460 470 480 490 500
VAEKDENLPV LLPLEVRTHE DGRSPLPDTP EFAECACPKC GGKARRETDT
510 520 530 540 550
MDTFVESSWY FARYTSASKD DGAFDPAALK YWMPVDQYIG GVEHAILHLL
560 570 580 590 600
YSRFFVKALR DCGYMDLDEP FANLLTQGMV LKEGAKMSKS KGNVVDPTEM
610 620 630 640 650
IARYGADTVR LFCLFAAPPE RDFDWSDSGI EGSYRFIGRI WRLAEELSGV
660 670 680 690 700
LLPVKACSAT AADAATPQGK DLRNKEHATV RKAGADISDR FQFNTAIAAV
710 720 730 740 750
MELVNALYLA KDELSGDEGG RKVLSSAVAT VLTLLSPITP HIAEELWASI
760 770 780 790 800
GNAGRITDEP WPQWSEEALA RDEETIVVQI NGKLRGRVSV PAGADAKAIE
810 820 830
AAALSEPNVA RHLEDVTVRK VVVIPGKLVN VVVG
Length:834
Mass (Da):93,505
Last modified:March 3, 2009 - v1
Checksum:iF3DE26FD5DD02836
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001197 Genomic DNA. Translation: ACL10027.1.
RefSeqiYP_002437495.1. NC_011769.1.

Genome annotation databases

EnsemblBacteriaiACL10027; ACL10027; DvMF_3090.
GeneIDi7175036.
KEGGidvm:DvMF_3090.
PATRICi21776719. VBIDesVul86729_3352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001197 Genomic DNA. Translation: ACL10027.1 .
RefSeqi YP_002437495.1. NC_011769.1.

3D structure databases

ProteinModelPortali B8DJF0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 883.DvMF_3090.

Proteomic databases

PRIDEi B8DJF0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL10027 ; ACL10027 ; DvMF_3090 .
GeneIDi 7175036.
KEGGi dvm:DvMF_3090.
PATRICi 21776719. VBIDesVul86729_3352.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi VVHCDAC.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci DVUL883:GCJ5-3170-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Desulfovibrio vulgaris str. 'Miyazaki F'."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Hazen T.C., Richardson P.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Miyazaki F / DSM 19637.

Entry informationi

Entry nameiSYL_DESVM
AccessioniPrimary (citable) accession number: B8DJF0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3