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B8DHP2

- PROB_LISMH

UniProt

B8DHP2 - PROB_LISMH

Protein

Glutamate 5-kinase

Gene

proB

Organism
Listeria monocytogenes serotype 4a (strain HCC23)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

    Catalytic activityi

    ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei14 – 141ATPUniRule annotation
    Binding sitei54 – 541SubstrateUniRule annotation
    Binding sitei141 – 1411SubstrateUniRule annotation
    Binding sitei157 – 1571Substrate; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi177 – 1782ATPUniRule annotation
    Nucleotide bindingi219 – 2257ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate 5-kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLMON552536:GIW4-1346-MONOMER.
    UniPathwayiUPA00098; UER00359.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
    Alternative name(s):
    Gamma-glutamyl kinaseUniRule annotation
    Short name:
    GKUniRule annotation
    Gene namesi
    Name:proBUniRule annotation
    Ordered Locus Names:LMHCC_1313
    OrganismiListeria monocytogenes serotype 4a (strain HCC23)
    Taxonomic identifieri552536 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000000743: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Glutamate 5-kinasePRO_1000193698Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi552536.LMHCC_1313.

    Structurei

    3D structure databases

    ProteinModelPortaliB8DHP2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamate 5-kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0263.
    HOGENOMiHOG000246368.
    KOiK00931.
    OMAiTKETNHI.
    OrthoDBiEOG6PGK7G.

    Family and domain databases

    Gene3Di3.40.1160.10. 1 hit.
    HAMAPiMF_00456. ProB.
    InterProiIPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    [Graphical view]
    PfamiPF00696. AA_kinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000729. GK. 1 hit.
    PRINTSiPR00474. GLU5KINASE.
    SUPFAMiSSF53633. SSF53633. 1 hit.
    TIGRFAMsiTIGR01027. proB. 1 hit.
    PROSITEiPS00902. GLUTAMATE_5_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8DHP2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRESLKNSKR LVIKVGTSTL MYGNGHINLR TIEKLAMVLS DLRNEGKEVI    50
    LVSSGAIGVG CHKLQLPVRP TSIPDLQAVA SVGQSELMHI YSKFFGEYGQ 100
    VVGQVLLTRD VTDFPISREN VMNTLDSLLS RGIIPIVNEN DTVAVEELEH 150
    VTKYGDNDLL SAIVAKLVQA DLLIMLSDID GFYGSNPTTD PDAVMFSEIN 200
    QITPEIEALA GGRGSKFGTG GMLTKLSAAS YCMESNQKMI LTNGKNPTVI 250
    FNIMQGEQVG TLFASKKEEL SHDRTH 276
    Length:276
    Mass (Da):30,059
    Last modified:March 3, 2009 - v1
    Checksum:i9A8CAD84B0B4131B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001175 Genomic DNA. Translation: ACK39658.1.
    RefSeqiYP_002350272.1. NC_011660.1.

    Genome annotation databases

    EnsemblBacteriaiACK39658; ACK39658; LMHCC_1313.
    GeneIDi7080243.
    KEGGilmh:LMHCC_1313.
    PATRICi20317741. VBILisMon86872_1301.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001175 Genomic DNA. Translation: ACK39658.1 .
    RefSeqi YP_002350272.1. NC_011660.1.

    3D structure databases

    ProteinModelPortali B8DHP2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 552536.LMHCC_1313.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK39658 ; ACK39658 ; LMHCC_1313 .
    GeneIDi 7080243.
    KEGGi lmh:LMHCC_1313.
    PATRICi 20317741. VBILisMon86872_1301.

    Phylogenomic databases

    eggNOGi COG0263.
    HOGENOMi HOG000246368.
    KOi K00931.
    OMAi TKETNHI.
    OrthoDBi EOG6PGK7G.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00359 .
    BioCyci LMON552536:GIW4-1346-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1160.10. 1 hit.
    HAMAPi MF_00456. ProB.
    InterProi IPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    IPR019797. Glutamate_5-kinase_CS.
    [Graphical view ]
    Pfami PF00696. AA_kinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000729. GK. 1 hit.
    PRINTSi PR00474. GLU5KINASE.
    SUPFAMi SSF53633. SSF53633. 1 hit.
    TIGRFAMsi TIGR01027. proB. 1 hit.
    PROSITEi PS00902. GLUTAMATE_5_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of lineage III Listeria monocytogenes strain HCC23."
      Steele C.L., Donaldson J.R., Paul D., Banes M.M., Arick T., Bridges S.M., Lawrence M.L.
      J. Bacteriol. 193:3679-3680(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HCC23.

    Entry informationi

    Entry nameiPROB_LISMH
    AccessioniPrimary (citable) accession number: B8DHP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3