B8DHJ5 (GSA2_LISMH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase 2
Short name=GSA 2
EC=5.4.3.8

Alternative name(s):
Glutamate-1-semialdehyde aminotransferase 2
Short name=GSA-AT 2

Gene names

Name:	hemL2
Ordered Locus Names:	LMHCC_1016

Organism

Listeria monocytogenes serotype 4a (strain HCC23) [Complete proteome] [HAMAP]

Taxonomic identifier

552536 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria › Listeria monocytogenes

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375
Cofactor	Pyridoxal phosphate By similarity. HAMAP-Rule MF_00375
Pathway	Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_00375
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00375.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: HAMAP protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 429	429	Glutamate-1-semialdehyde 2,1-aminomutase 2 HAMAP-Rule MF_00375		PRO_0000382333
Amino acid modifications
	Modified residue	268	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8DHJ5 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 02AD16E4E8FF2E30	FASTA	429	46,561
	10 20 30 40 50 60 MQIYSKSEKA FKEAKKVLPG GVNSPVRAFN SVDASPVFMD HGKGAYITDI DGNEYIDYVL 70 80 90 100 110 120 SWGPLILGHA NPSVVQAITN AAMKGTSFGT PTEIETELAK LVIERVPSIE IVRMVSSGTE 130 140 150 160 170 180 ATMSAIRLAR GYTKREKILK FEGSYHGHGD SLLIKAGSGV ATLGLPDSPG VTKGLAADTI 190 200 210 220 230 240 TVPYNDIEGA KLAFEKYGEE IAAVIVEPVA GNMGVVPPIE GFLEGLRELT TNYGSLLIFD 250 260 270 280 290 300 EVMTGFRVDY YSAQGYYVVT PDLTCLGKVI GGGLPVGAYG GKKEIMEQIA PAGSIYQAGT 310 320 330 340 350 360 LSGNPLAMNA GFETVRQLTP QDYDVFRTLI KRMEEGLTEI SARRQVPLSI NKAGSMFGFF 370 380 390 400 410 420 FTDQKVTNFD TAKTSDLEFF RSYYREMLGQ GIFLPPSQFE GVFISTMHTE KEIDKTLDAF DTTCKILRG

References

[1]	"Genome sequence of lineage III Listeria monocytogenes strain HCC23." Steele C.L., Donaldson J.R., Paul D., Banes M.M., Arick T., Bridges S.M., Lawrence M.L. J. Bacteriol. 193:3679-3680(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HCC23.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001175 Genomic DNA. Translation: ACK39364.1.
RefSeq	YP_002349978.1. NC_011660.1.
3D structure databases
ProteinModelPortal	B8DHJ5.
ModBase	Search...
Protein-protein interaction databases
STRING	552536.LMHCC_1016.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACK39364; ACK39364; LMHCC_1016.
GeneID	7079949.
KEGG	lmh:LMHCC_1016.
PATRIC	20317149. VBILisMon86872_1005.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0001.
HOGENOM	HOG000020210.
KO	K01845.
OMA	ANMIVER.
ProtClustDB	PRK00062.
Enzyme and pathway databases
BioCyc	LMON552536:GIW4-1052-MONOMER.
UniPathway	UPA00251; UER00317.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAP	MF_00375. HemL_aminotrans_3.
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF5. PTHR11986:SF5. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00713. hemL. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSA2_LISMH

Accession

Primary (citable) accession number: B8DHJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 1, 2009
Last sequence update:	March 3, 2009
Last modified:	May 29, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program