B8DH65 (MSCL_LISMH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Large-conductance mechanosensitive channel

Gene names

Name:	mscL
Ordered Locus Names:	LMHCC_0496

Organism

Listeria monocytogenes serotype 4a (strain HCC23) [Complete proteome] [HAMAP]

Taxonomic identifier

552536 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	128 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity. HAMAP MF_00115
Subunit structure	Homopentamer By similarity. HAMAP MF_00115
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_00115.
Sequence similarities	Belongs to the MscL family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Ionic channel
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 128	128	Large-conductance mechanosensitive channel HAMAP MF_00115		PRO_1000191376
Regions
	Transmembrane	33 – 53	21	Helical; Potential
	Transmembrane	70 – 90	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	B8DH65 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 87CB121823326806	FASTA	128	14,239
	10 20 30 40 50 60 MKKMLVEFRD FALKGNVLDL AVAVVIGAAF GKIVSSLVDN IIMPLVGVLL GGLDFTDLSF 70 80 90 100 110 120 KVGKSVIQYG AFIQSIVDFI IIAFAIFIFV KVLTSFIKKK EQTVEETPVP PTEEYLKEIR DLLKEQQK

References

[1]	"Genome sequence of lineage III Listeria monocytogenes strain HCC23." Steele C.L., Donaldson J.R., Paul D., Banes M.M., Arick T., Bridges S.M., Lawrence M.L. J. Bacteriol. 193:3679-3680(2011) [PubMed: 21602330] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HCC23.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001175 Genomic DNA. Translation: ACK38853.1.
RefSeq	YP_002349467.1. NC_011660.1.
3D structure databases
ProteinModelPortal	B8DH65.
ModBase	Search...
Protein-protein interaction databases
STRING	B8DH65.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7079205.
GenomeReviews	Gene locus LMHCC_0496 in contig CP001175_GR.
KEGG	lmh:LMHCC_0496.
PATRIC	20316061. VBILisMon86872_0490.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG727604.
OMA	VIDFVIV.
ProtClustDB	PRK13953.
Family and domain databases
HAMAP	MF_00115. MscL. [Tree]
InterPro	IPR019823. Mechanosensitive_channel_CS. IPR001185. MS_channel. [Graphical view]
KO	K03282.
Pfam	PF01741. MscL. 1 hit. [Graphical view]
PRINTS	PR01264. MECHCHANNEL.
SUPFAM	SSF81330. MS_channel. 1 hit.
TIGRFAMs	TIGR00220. MscL. 1 hit.
PROSITE	PS01327. MSCL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MSCL_LISMH

Accession

Primary (citable) accession number: B8DH65

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program