B8DG73 (ALR_LISMH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alanine racemase
EC=5.1.1.1

Gene names

Name:	alr
Ordered Locus Names:	LMHCC_1740

Organism

Listeria monocytogenes serotype 4a (strain HCC23) [Complete proteome] [HAMAP]

Taxonomic identifier

552536 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Provides the D-alanine required for cell wall biosynthesis By similarity. HAMAP MF_01201
Catalytic activity	L-alanine = D-alanine. HAMAP MF_01201
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01201
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201 Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanine metabolic process Inferred from electronic annotation. Source: InterPro cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alanine racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 368	368	Alanine racemase HAMAP MF_01201		PRO_1000164602
Sites
	Active site	40	1	Proton acceptor; specific for D-alanine By similarity
	Active site	263	1	Proton acceptor; specific for L-alanine By similarity
Amino acid modifications
	Modified residue	40	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8DG73 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: D8D92D767C52AC45	FASTA	368	40,905
	10 20 30 40 50 60 MVTGWHRPTW IEIDRAAIRE NIKNEQNKLP ENVDLWAVVK ANAYGHGIIE VARTAKEAGA 70 80 90 100 110 120 KGFCVAILDE ALALREAGFQ DDFILVLGAT RKEDANLAAK NHISLTVFRE DWLEDLTLEA 130 140 150 160 170 180 PLRIHLKVDS GMGRLGIRTV EEARQIETTI ASDNQLQLEG IYTHFATADQ LETSYFEQQL 190 200 210 220 230 240 AKFQTILTSL KNRPTYVHTA NSAASLLQPQ IGFDAIRFGI SMYGLTPSTE IKTSLPFELK 250 260 270 280 290 300 PALALYTEMV HVKELAPGDS VSYGATYTAT EREWVATLPI GYADGLIRHY SGFHVLVGGE 310 320 330 340 350 360 LAPIIGRVCM DQTIIKLPRE FQTGSKVTII GEDNGNAITA DDAAQYLDTI NYEVTCLLNE RIPRKYLH

References

[1]	"Genome sequence of lineage III Listeria monocytogenes strain HCC23." Steele C.L., Donaldson J.R., Paul D., Banes M.M., Arick T., Bridges S.M., Lawrence M.L. J. Bacteriol. 193:3679-3680(2011) [PubMed: 21602330] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HCC23.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001175 Genomic DNA. Translation: ACK40081.1.
RefSeq	YP_002350695.1. NC_011660.1.
3D structure databases
ProteinModelPortal	B8DG73.
ModBase	Search...
Protein-protein interaction databases
STRING	B8DG73.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7081434.
GenomeReviews	Gene locus LMHCC_1740 in contig CP001175_GR.
KEGG	lmh:LMHCC_1740.
PATRIC	20318605. VBILisMon86872_1727.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG712172.
OMA	TRKEDAN.
ProtClustDB	CLSK564147.
Family and domain databases
HAMAP	MF_01201. Ala_racemase. [Tree]
InterPro	IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. [Graphical view]
Gene3D	G3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
KO	K01775.
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
SMART	SM01005. Ala_racemase_C. 1 hit. [Graphical view]
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMs	TIGR00492. Alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALR_LISMH

Accession

Primary (citable) accession number: B8DG73

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program