B8DFY0 (GCST_LISMH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	LMHCC_1223

Organism

Listeria monocytogenes serotype 4a (strain HCC23) [Complete proteome] [HAMAP]

Taxonomic identifier

552536 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Aminomethyltransferase HAMAP MF_00259		PRO_1000125641

Sequences

	Sequence		Length	Mass (Da)
	B8DFY0 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: DF9330E8EC95F31D	FASTA	362	39,465
	10 20 30 40 50 60 MTELLKTPIH PLYAKYGAKT IDFGGWDLPV QFAGIKAEHE AVRTDAGLFD VSHMGEILVE 70 80 90 100 110 120 GPDSTSYLQY LLTNDIEKIK IGKAQYNIMC YETGGTVDDL VVYKKSETEY ILVVNAANTA 130 140 150 160 170 180 KDFEWMVKNI QGDVSVTNVS SEYGQLALQG PNAEKILAKL TDVDLSSISF FGFVEDADVA 190 200 210 220 230 240 GVKTIISRSG YTGEDGFEIY MPSADAGKVF EAILAEGVAP IGLGARDTLR LEAVLALYGQ 250 260 270 280 290 300 ELSKDITPLE AGLNFAVKLK KEADFIGKEA LIKQKEAGLN RKLVGIELIE RGIPRHDYPV 310 320 330 340 350 360 FLNDEEIGIV TSGTQSPTLG TNIGLALIDT AYTELGQEVE VGIRNKKIKA KIVPTPFYKR AK

References

[1]	"Genome sequence of lineage III Listeria monocytogenes strain HCC23." Steele C.L., Donaldson J.R., Paul D., Banes M.M., Arick T., Bridges S.M., Lawrence M.L. J. Bacteriol. 193:3679-3680(2011) [PubMed: 21602330] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HCC23.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001175 Genomic DNA. Translation: ACK39570.1.
RefSeq	YP_002350184.1. NC_011660.1.
3D structure databases
ProteinModelPortal	B8DFY0.
ModBase	Search...
Protein-protein interaction databases
STRING	B8DFY0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7081334.
GenomeReviews	Gene locus LMHCC_1223 in contig CP001175_GR.
KEGG	lmh:LMHCC_1223.
PATRIC	20317559. VBILisMon86872_1210.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG299834.
OMA	KALYGGM.
ProtClustDB	PRK00389.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_LISMH

Accession

Primary (citable) accession number: B8DFY0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program