B8DFU4 (IDI2_LISMH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Isopentenyl-diphosphate delta-isomerase
Short name=IPP isomerase
EC=5.3.3.2

Alternative name(s):
Isopentenyl pyrophosphate isomerase

Gene names

Name:	fni
Ordered Locus Names:	LMHCC_1186

Organism

Listeria monocytogenes serotype 4a (strain HCC23) [Complete proteome] [HAMAP]

Taxonomic identifier

552536 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria › Listeria monocytogenes

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) By similarity. HAMAP-Rule MF_00354
Catalytic activity	Isopentenyl diphosphate = dimethylallyl diphosphate. HAMAP-Rule MF_00354
Cofactor	FMN By similarity. NADPH By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the IPP isomerase type 2 family.

Ontologies

Keywords
Biological process	Isoprene biosynthesis
Cellular component	Cytoplasm
Ligand	FMN Flavoprotein NADP
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation-reduction process Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	FMN binding Inferred from electronic annotation. Source: InterPro isopentenyl-diphosphate delta-isomerase activity Inferred from electronic annotation. Source: HAMAP oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Isopentenyl-diphosphate delta-isomerase HAMAP-Rule MF_00354		PRO_1000133431

Sequences

	Sequence		Length	Mass (Da)
	B8DFU4 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 29B8B499BD73AAC9	FASTA	358	39,420
	10 20 30 40 50 60 MQKNDDLLRE RRKDEHVALG VKQNEQLAPS SLEDIQLIGT SIPRYNVKDI DLTTTIVGTN 70 80 90 100 110 120 VPFPFYINAM TGGSRHTKKI NAELAEIARE VAIPMAVGSQ SAALKNSSLI DTYKIVREIN 130 140 150 160 170 180 PNGMILANIS PEVALQEGLR AIEMLEADAL QIHINPAQEL VMQEGDRSFS HWLTRIEKYV 190 200 210 220 230 240 KLSPVPVVVK EVGFGMTRET VATLASVGVQ SVDLAGKGGT NFAQIENDRR RDQAYDFLLD 250 260 270 280 290 300 WGISTGQALI DMQHQDAPKI AYLASGGIRN PLDIVKALAL GADSVGMAGQ IIYSLKKEGL 310 320 330 340 350 TKTIEKLELW KEQLRSLFVL ADAKNISELK TTPLIISGEL AKWGTLREID LVKLANRK

References

[1]	"Genome sequence of lineage III Listeria monocytogenes strain HCC23." Steele C.L., Donaldson J.R., Paul D., Banes M.M., Arick T., Bridges S.M., Lawrence M.L. J. Bacteriol. 193:3679-3680(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HCC23.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001175 Genomic DNA. Translation: ACK39534.1.
RefSeq	YP_002350148.1. NC_011660.1.
3D structure databases
ProteinModelPortal	B8DFU4.
ModBase	Search...
Protein-protein interaction databases
STRING	552536.LMHCC_1186.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACK39534; ACK39534; LMHCC_1186.
GeneID	7081298.
KEGG	lmh:LMHCC_1186.
PATRIC	20317487. VBILisMon86872_1174.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1304.
HOGENOM	HOG000072127.
KO	K01823.
OMA	FEFPFYI.
ProtClustDB	PRK05437.
Enzyme and pathway databases
BioCyc	LMON552536:GIW4-1222-MONOMER.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00354. Idi_2.
InterPro	IPR013785. Aldolase_TIM. IPR000262. FMN-dep_DH. IPR011179. IPdP_isomerase. [Graphical view]
PANTHER	PTHR10578:SF3. PTHR10578:SF3. 1 hit.
Pfam	PF01070. FMN_dh. 2 hits. [Graphical view]
PIRSF	PIRSF003314. IPP_isomerase. 1 hit.
TIGRFAMs	TIGR02151. IPP_isom_2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IDI2_LISMH

Accession

Primary (citable) accession number: B8DFU4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program