B8DE13 (URK_LISMH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uridine kinase
EC=2.7.1.48

Alternative name(s):
Cytidine monophosphokinase
Uridine monophosphokinase

Gene names

Name:	udk
Ordered Locus Names:	LMHCC_1073

Organism

Listeria monocytogenes serotype 4a (strain HCC23) [Complete proteome] [HAMAP]

Taxonomic identifier

552536 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria › Listeria monocytogenes

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + uridine = ADP + UMP. HAMAP-Rule MF_00551 ATP + cytidine = ADP + CMP. HAMAP-Rule MF_00551
Pathway	Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3. HAMAP-Rule MF_00551 Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1. HAMAP-Rule MF_00551
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the uridine kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	CTP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway UMP salvage Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro uridine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Uridine kinase HAMAP-Rule MF_00551		PRO_1000200516
Regions
	Nucleotide binding	12 – 19	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	B8DE13 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 016F262A8D43E5E4	FASTA	209	24,148
	10 20 30 40 50 60 MTKKPIVVGV TGGSGSGKTS VTKAICDHFS GHSILMIAQD VYYHDQANIS FEDRLKVNYD 70 80 90 100 110 120 HPLAFDTDLL ISHIAALRRY ETIEKPIYDY AKYTRKKEVE IQEPREVIIL EGILILEDKR 130 140 150 160 170 180 LRDLMDIKVY VDTDDDIRFI RRLLRDMKER GRTMDSVIEQ YLSVVKPMHN EFIEPTKKFA 190 200 DIIIPEGGEN HVAIDLMTTK IESILQKHV

References

[1]	"Genome sequence of lineage III Listeria monocytogenes strain HCC23." Steele C.L., Donaldson J.R., Paul D., Banes M.M., Arick T., Bridges S.M., Lawrence M.L. J. Bacteriol. 193:3679-3680(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HCC23.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001175 Genomic DNA. Translation: ACK39421.1.
RefSeq	YP_002350034.1. NC_011660.1.
3D structure databases
ProteinModelPortal	B8DE13.
ModBase	Search...
Protein-protein interaction databases
STRING	552536.LMHCC_1073.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACK39421; ACK39421; LMHCC_1073.
GeneID	7080005.
KEGG	lmh:LMHCC_1073.
PATRIC	20317261. VBILisMon86872_1061.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0572.
HOGENOM	HOG000262756.
KO	K00876.
OMA	EMPQYDF.
ProtClustDB	PRK05480.
Enzyme and pathway databases
BioCyc	LMON552536:GIW4-1108-MONOMER.
UniPathway	UPA00574; UER00637. UPA00579; UER00640.
Family and domain databases
HAMAP	MF_00551. Uridine_kinase.
InterPro	IPR006083. PRK/URK. IPR000764. Uridine_kinase. [Graphical view]
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PRINTS	PR00988. URIDINKINASE.
TIGRFAMs	TIGR00235. udk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

URK_LISMH

Accession

Primary (citable) accession number: B8DE13

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program