Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B8DDZ2

- PUR9_LISMH

UniProt

B8DDZ2 - PUR9_LISMH

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Listeria monocytogenes serotype 4a (strain HCC23)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciLMON552536:GIW4-814-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:LMHCC_0799
    OrganismiListeria monocytogenes serotype 4a (strain HCC23)
    Taxonomic identifieri552536 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000000743: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509Bifunctional purine biosynthesis protein PurHPRO_1000122963Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi552536.LMHCC_0799.

    Structurei

    3D structure databases

    ProteinModelPortaliB8DDZ2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiGIGQADN.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8DDZ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRALISVSD KNGIVPFAEK LVELGVEIIS TGGTKAAFEQ AGVPVTGIEE    50
    VTEFPEMLDG RVKTLHPAIH GGLLARRDTA EHMEAIAAHD IKPIDLVVVN 100
    LYPFQETIQK SGVTLEEAIE NIDIGGPSML RSAAKNYAAV TVVVDTVDYD 150
    TVLTELEEHG ATTFETRQRL AAKVFRHTAA YDALIAEYLT NITGETFPEK 200
    VTLTYNRKQV LRYGENPHQD AAFYTEPGTV ENSISSAKQL HGKELSYNNI 250
    RDADAALKIA SEFTEPVAVA VKHMNPCGVG VGENIEEAYL KAYEADETSI 300
    FGGIVALNKE VDAKTAEHMS KIFLEIIIAP SFSEEAFAIL TKKKNIRLLT 350
    VPFAGSVKGF EKTSVNGGLL IQASDSVIED TASYEVVTEK QPTEAEMKAL 400
    IAQWKIVKHV KSNAIVVGSD KQTLGIGAGQ MNRIGSALIA LEQAGEKAKG 450
    AVLASDAFFP MDDTVEAAAK AGITAIIQPG GSIKDKESIA MANKYGISMV 500
    LTHVRHFKH 509
    Length:509
    Mass (Da):54,912
    Last modified:March 3, 2009 - v1
    Checksum:iD4182C31B3A9E31A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001175 Genomic DNA. Translation: ACK39151.1.
    RefSeqiYP_002349765.1. NC_011660.1.

    Genome annotation databases

    EnsemblBacteriaiACK39151; ACK39151; LMHCC_0799.
    GeneIDi7079819.
    KEGGilmh:LMHCC_0799.
    PATRICi20316671. VBILisMon86872_0790.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001175 Genomic DNA. Translation: ACK39151.1 .
    RefSeqi YP_002349765.1. NC_011660.1.

    3D structure databases

    ProteinModelPortali B8DDZ2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 552536.LMHCC_0799.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK39151 ; ACK39151 ; LMHCC_0799 .
    GeneIDi 7079819.
    KEGGi lmh:LMHCC_0799.
    PATRICi 20316671. VBILisMon86872_0790.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi GIGQADN.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci LMON552536:GIW4-814-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of lineage III Listeria monocytogenes strain HCC23."
      Steele C.L., Donaldson J.R., Paul D., Banes M.M., Arick T., Bridges S.M., Lawrence M.L.
      J. Bacteriol. 193:3679-3680(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HCC23.

    Entry informationi

    Entry nameiPUR9_LISMH
    AccessioniPrimary (citable) accession number: B8DDZ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3