Skip Header

Contribute Send feedback
Read comments (?) or add your own

B8DDS1 (B8DDS1_LISMH) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE HAMAP MF_01208
Ordered Locus Names:LMHCC_0725
OrganismListeria monocytogenes serotype 4a (strain HCC23) [Complete proteome] [HAMAP] EMBL ACK39080.1
Taxonomic identifier552536 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 SAAS SAAS004467

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP MF_01208 SAAS SAAS004467

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region122 – 13095-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site9615-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site10015-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site10215-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1261Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
B8DDS1 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 0CD2A7AC395DA8E6

FASTA20922,748
        10         20         30         40         50         60 
MSIEKQVAEQ LLEIKAVFLK PNDPFTWASG IKSPIYCDNR LTLGFPKVRQ FIAKSLAEKI 

        70         80         90        100        110        120 
KQTFGEVDVV AGTATAGIPH AAWVSDLLDL PMVYVRSKAK EHGKGNQIEG PITKGQKVVV 

       130        140        150        160        170        180 
IEDLISTGGS SLKAVEALEE AGAEVVGIAA IFTYGLDKGK QLLEASGTKL VTLTNYDELI 

       190        200 
EVALNENYVT AEDMATLKEW KKNPENWGK

« Hide

References

[1]"Genome sequence of lineage III Listeria monocytogenes strain HCC23."
Steele C.L., Donaldson J.R., Paul D., Banes M.M., Arick T., Bridges S.M., Lawrence M.L.
J. Bacteriol. 193:3679-3680(2011) [PubMed: 21602330] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HCC23.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001175 Genomic DNA. Translation: ACK39080.1.
RefSeqYP_002349694.1. NC_011660.1.

3D structure databases

ProteinModelPortalB8DDS1.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8DDS1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7078531.
GenomeReviewsGene locus LMHCC_0725 in contig CP001175_GR.
KEGGlmh:LMHCC_0725.
PATRIC20316523. VBILisMon86872_0720.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG404341.
OMALPMTYVR.
ProtClustDBPRK00455.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB8DDS1_LISMH
AccessionPrimary (citable) accession number: B8DDS1
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info