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B8DDM6

- FTHS_LISMH

UniProt

B8DDM6 - FTHS_LISMH

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Listeria monocytogenes serotype 4a (strain HCC23)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi69 – 768ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLMON552536:GIW4-695-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:LMHCC_0680
    OrganismiListeria monocytogenes serotype 4a (strain HCC23)
    Taxonomic identifieri552536 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000000743: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 560560Formate--tetrahydrofolate ligasePRO_1000185256Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi552536.LMHCC_0680.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8DDM6-1 [UniParc]FASTAAdd to Basket

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    MSNKVKSDIE IASKAEILPV TTIAEHLGLD ADALELYGKY KAKLSYDTIH    50
    SLKDKETGKL VLVTAINPTP AGEGKSTVTV GLGDALSKKD KKTVIALREP 100
    SLGPTMGIKG GATGGGYAQV IPMEDINLHF TGDFHAITAA NNALSAFIDN 150
    HMQQGNDLDI DGRRIVWKRV VDLNDRALRK VVVGLGGPIQ GVPREDGFDI 200
    TVASEIMAII CLASDLKDLK KRLSEIVIGY NYKKEPITVG EMGYEGALTL 250
    LLKDALKPNL VQTLEHTPAI VHGGPFANIA HGCNSVSATS TALRLGEYVV 300
    TEAGFGADLG AEKFLDIKVP ALGKAPDCVV IVATIRALKM HGGALKTELS 350
    EENVDALAKG FTNLQKHTES IQTFGIPYVV AINKFITDSD AEVAKLEALC 400
    EEHGIPFSLT EVWEKGGDGG LELADKVIAA VESGEADYKR IYDDAWSIEE 450
    KLEAIVTKVY GGIGVELSSK AQKQIVEFKK YGWDRYPICM AKTQYSLSDD 500
    PTLLGRPTDF VIHIREFIPK LGAGFVVALT GDVMTMPGLP KKPAALNMDV 550
    DENGNAQGLF 560
    Length:560
    Mass (Da):60,130
    Last modified:March 3, 2009 - v1
    Checksum:iED5D2B76E1DF66BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001175 Genomic DNA. Translation: ACK39035.1.
    RefSeqiYP_002349649.1. NC_011660.1.

    Genome annotation databases

    EnsemblBacteriaiACK39035; ACK39035; LMHCC_0680.
    GeneIDi7078486.
    KEGGilmh:LMHCC_0680.
    PATRICi20316430. VBILisMon86872_0674.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001175 Genomic DNA. Translation: ACK39035.1 .
    RefSeqi YP_002349649.1. NC_011660.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 552536.LMHCC_0680.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK39035 ; ACK39035 ; LMHCC_0680 .
    GeneIDi 7078486.
    KEGGi lmh:LMHCC_0680.
    PATRICi 20316430. VBILisMon86872_0674.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci LMON552536:GIW4-695-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of lineage III Listeria monocytogenes strain HCC23."
      Steele C.L., Donaldson J.R., Paul D., Banes M.M., Arick T., Bridges S.M., Lawrence M.L.
      J. Bacteriol. 193:3679-3680(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HCC23.

    Entry informationi

    Entry nameiFTHS_LISMH
    AccessioniPrimary (citable) accession number: B8DDM6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3