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B8DCT8 (IOLA_LISMH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methylmalonate semialdehyde dehydrogenase [acylating]
Short name=MMSA dehydrogenase
Short name=MMSDH
Short name=MSDH
EC=1.2.1.27
Alternative name(s):
Malonate semialdehyde dehydrogenase [acetylating]
Short name=MSA dehydrogenase
EC=1.2.1.18
Gene names
Name:iolA
Ordered Locus Names:LMHCC_2253
OrganismListeria monocytogenes serotype 4a (strain HCC23) [Complete proteome] [HAMAP]
Taxonomic identifier552536 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria ›

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively By similarity. HAMAP-Rule MF_01670

Catalytic activity

3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H. HAMAP-Rule MF_01670

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH. HAMAP-Rule MF_01670

Pathway

Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 7/7. HAMAP-Rule MF_01670

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the aldehyde dehydrogenase family. IolA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 488488Methylmalonate semialdehyde dehydrogenase [acylating] HAMAP-Rule MF_01670
PRO_1000187315

Regions

Nucleotide binding176 – 1805NAD By similarity

Sites

Active site2841Nucleophile By similarity
Binding site3821NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
B8DCT8 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 0D68FA419BCFD239

FASTA48853,380
        10         20         30         40         50         60 
MADVRKLKNY IDGEWVESKT DKYEDVINPA TGEVLCQVPI STRAELDQAA VIAEQAFEKW 

        70         80         90        100        110        120 
SQVAVPRRAR VLFSFQQLLI QHKEELARLI TLENGKNLSE ARGEVQRGIE NVEFAAGAPT 

       130        140        150        160        170        180 
LMMGDSLASI ATDVEAANYR YPVGVVGGIA PFNFPMMVPC WMFPMAIALG NSFILKPSER 

       190        200        210        220        230        240 
TPLLMEKLVE LFSEAGLPKG VFNVVYGAHD VVNGILENEI IKAVSFVGSK PVGEYVYKTG 

       250        260        270        280        290        300 
SANLKRVQAL TGAKNHTIVL NDADLEDTVT NVISAAFGSA GERCMACAVV TVEEDIADEF 

       310        320        330        340        350        360 
LEALRTAAKN VKIGNGLDDG VFLGPVIREE NQKRTIAYIE KGVEEGAKLT VDGRETGLSE 

       370        380        390        400        410        420 
GHFVGPTILE DVTTDMTIWK DEIFAPVLSV IRVKNLQEAV RVANLSEFAN GACIFTNNAK 

       430        440        450        460        470        480 
AIRYFREKID AGMLGVNLGV PAPMAFFPFS GWKSSFYGTL HANGKDSVDF YTHKKVVTAR 


YSLKGYEE

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References

[1]"Genome sequence of lineage III Listeria monocytogenes strain HCC23."
Steele C.L., Donaldson J.R., Paul D., Banes M.M., Arick T., Bridges S.M., Lawrence M.L.
J. Bacteriol. 193:3679-3680(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HCC23.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001175 Genomic DNA. Translation: ACK40591.1.
RefSeqYP_002351205.1. NC_011660.1.

3D structure databases

ProteinModelPortalB8DCT8.
ModBaseSearch...

Protein-protein interaction databases

STRING552536.LMHCC_2253.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACK40591; ACK40591; LMHCC_2253.
GeneID7079435.
KEGGlmh:LMHCC_2253.
PATRIC20319630. VBILisMon86872_2238.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271507.
KOK00140.
OMAVANQSEF.
ProtClustDBCLSK2460970.

Enzyme and pathway databases

BioCycLMON552536:GIW4-2286-MONOMER.
UniPathwayUPA00076; UER00148.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_01670. IolA.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
IPR023510. MeMal-semiAld_DH_GmP_bac.
[Graphical view]
PANTHERPTHR11699:SF27. PTHR11699:SF27. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01722. MMSDH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOLA_LISMH
AccessionPrimary (citable) accession number: B8DCT8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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