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Protein

5-dehydro-2-deoxygluconokinase

Gene

iolC

Organism
Listeria monocytogenes serotype 4a (strain HCC23)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP).UniRule annotation

Catalytic activityi

ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate.UniRule annotation

Pathwayi: myo-inositol degradation into acetyl-CoA

This protein is involved in step 5 of the subpathway that synthesizes acetyl-CoA from myo-inositol.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. 5-deoxy-glucuronate isomerase (iolB)
  5. 5-dehydro-2-deoxygluconokinase (iolC)
  6. no protein annotated in this organism
  7. Methylmalonate semialdehyde dehydrogenase [acylating] (iolA)
This subpathway is part of the pathway myo-inositol degradation into acetyl-CoA, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from myo-inositol, the pathway myo-inositol degradation into acetyl-CoA and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLMON552536:GIW4-2284-MONOMER.
UniPathwayiUPA00076; UER00146.

Names & Taxonomyi

Protein namesi
Recommended name:
5-dehydro-2-deoxygluconokinaseUniRule annotation (EC:2.7.1.92UniRule annotation)
Alternative name(s):
2-deoxy-5-keto-D-gluconate kinaseUniRule annotation
Short name:
DKG kinaseUniRule annotation
Gene namesi
Name:iolCUniRule annotation
Ordered Locus Names:LMHCC_2251
OrganismiListeria monocytogenes serotype 4a (strain HCC23)
Taxonomic identifieri552536 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3253255-dehydro-2-deoxygluconokinasePRO_1000187306Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliB8DCT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the carbohydrate kinase PfkB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000235951.
KOiK03338.
OMAiANRRHTI.
OrthoDBiEOG61VZF9.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_01668. IolC.
InterProiIPR002173. Carboh/pur_kinase_PfkB_CS.
IPR022841. DKG_kinase_firmi.
IPR030830. Myo_inos_iolC.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF00294. PfkB. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR04382. myo_inos_iolC_N. 1 hit.
PROSITEiPS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8DCT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLNKHSERK FDLITVGRAC IDLNAVEYNR PMEETMTFSK YVGGSPANIA
60 70 80 90 100
IGTAKLGLKV GFIGKISADQ HGRFIEKYMR DLSINTDGMV KDTEGRKVGL
110 120 130 140 150
AFTEIKSPDE CSILMYRENV ADLYLTPEEI SEDYIKEARV LLISGTALAQ
160 170 180 190 200
SPSREAVLKA VSLARKNDVA IAFELDYRPY TWTNTEETAV YYSLVAEQAD
210 220 230 240 250
VIIGTRDEFD MMENQVGGKN EATKAHLFQH QAEIVVIKHG VEGSFAYTKA
260 270 280 290 300
GETFQAKAYK TKVLKTFGAG DSYASAFLYG LFSGESIETA LKYGSAAASI
310 320
VVSKHSSSDA MPTADEIKAL IAQAE
Length:325
Mass (Da):35,657
Last modified:March 3, 2009 - v1
Checksum:i9B58A7E79AE28A03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001175 Genomic DNA. Translation: ACK40589.1.
RefSeqiWP_012581980.1. NC_011660.1.

Genome annotation databases

EnsemblBacteriaiACK40589; ACK40589; LMHCC_2251.
KEGGilmh:LMHCC_2251.
PATRICi20319626. VBILisMon86872_2236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001175 Genomic DNA. Translation: ACK40589.1.
RefSeqiWP_012581980.1. NC_011660.1.

3D structure databases

ProteinModelPortaliB8DCT6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACK40589; ACK40589; LMHCC_2251.
KEGGilmh:LMHCC_2251.
PATRICi20319626. VBILisMon86872_2236.

Phylogenomic databases

HOGENOMiHOG000235951.
KOiK03338.
OMAiANRRHTI.
OrthoDBiEOG61VZF9.

Enzyme and pathway databases

UniPathwayiUPA00076; UER00146.
BioCyciLMON552536:GIW4-2284-MONOMER.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_01668. IolC.
InterProiIPR002173. Carboh/pur_kinase_PfkB_CS.
IPR022841. DKG_kinase_firmi.
IPR030830. Myo_inos_iolC.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF00294. PfkB. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR04382. myo_inos_iolC_N. 1 hit.
PROSITEiPS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of lineage III Listeria monocytogenes strain HCC23."
    Steele C.L., Donaldson J.R., Paul D., Banes M.M., Arick T., Bridges S.M., Lawrence M.L.
    J. Bacteriol. 193:3679-3680(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HCC23.

Entry informationi

Entry nameiIOLC_LISMH
AccessioniPrimary (citable) accession number: B8DCT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: November 11, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.