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B8DCJ3

- HDOX_LISMH

UniProt

B8DCJ3 - HDOX_LISMH

Protein

Heme-degrading monooxygenase

Gene

isdG

Organism
Listeria monocytogenes serotype 4a (strain HCC23)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the biliverdin in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron.UniRule annotation

    Catalytic activityi

    Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi6 – 61IronUniRule annotation
    Sitei74 – 741Transition state stabilizerUniRule annotation
    Metal bindingi84 – 841Iron (heme axial ligand)UniRule annotation

    GO - Molecular functioni

    1. heme binding Source: UniProtKB-HAMAP
    2. heme oxygenase (decyclizing) activity Source: UniProtKB-HAMAP
    3. iron ion binding Source: UniProtKB-HAMAP
    4. monooxygenase activity Source: UniProtKB-KW

    GO - Biological processi

    1. heme catabolic process Source: UniProtKB-HAMAP
    2. iron assimilation Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciLMON552536:GIW4-2191-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heme-degrading monooxygenaseUniRule annotation (EC:1.14.99.3)
    Alternative name(s):
    Heme oxygenaseUniRule annotation
    Iron-regulated surface determinantUniRule annotation
    Iron-responsive surface determinantUniRule annotation
    Gene namesi
    Name:isdGUniRule annotation
    Ordered Locus Names:LMHCC_2158
    OrganismiListeria monocytogenes serotype 4a (strain HCC23)
    Taxonomic identifieri552536 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000000743: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 121121Heme-degrading monooxygenasePRO_1000165181Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi552536.LMHCC_2158.

    Structurei

    3D structure databases

    ProteinModelPortaliB8DCJ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 101100ABMAdd
    BLAST

    Sequence similaritiesi

    Belongs to the antibiotic biosynthesis monooxygenase family. Heme-degrading monooxygenase IsdG subfamily.UniRule annotation
    Contains 1 ABM domain.Curated

    Phylogenomic databases

    eggNOGiCOG2329.
    HOGENOMiHOG000008026.
    KOiK07145.
    OMAiFRESHSH.
    OrthoDBiEOG6GTZMS.

    Family and domain databases

    HAMAPiMF_01272. Heme_degrading_monooxygenase.
    InterProiIPR007138. ABM-like.
    IPR011008. Dimeric_a/b-barrel.
    IPR023953. IsdG.
    [Graphical view]
    PfamiPF03992. ABM. 1 hit.
    [Graphical view]
    SUPFAMiSSF54909. SSF54909. 1 hit.
    PROSITEiPS51725. ABM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8DCJ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIIVTNTIKV EKGAAEHVIR QFTGANGDGH PTKDIAEVEG FLGFELWHSK    50
    PEDKDYEEVV VTSKWESEEA QRNWVKSDSF KKAHGRTKDT REQREDRKGI 100
    VGNAIARFEV VHVQNPVIVE K 121
    Length:121
    Mass (Da):13,785
    Last modified:March 3, 2009 - v1
    Checksum:i95674EA508DA2D49
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001175 Genomic DNA. Translation: ACK40496.1.
    RefSeqiYP_002351110.1. NC_011660.1.

    Genome annotation databases

    EnsemblBacteriaiACK40496; ACK40496; LMHCC_2158.
    GeneIDi7079506.
    KEGGilmh:LMHCC_2158.
    PATRICi20319444. VBILisMon86872_2145.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001175 Genomic DNA. Translation: ACK40496.1 .
    RefSeqi YP_002351110.1. NC_011660.1.

    3D structure databases

    ProteinModelPortali B8DCJ3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 552536.LMHCC_2158.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK40496 ; ACK40496 ; LMHCC_2158 .
    GeneIDi 7079506.
    KEGGi lmh:LMHCC_2158.
    PATRICi 20319444. VBILisMon86872_2145.

    Phylogenomic databases

    eggNOGi COG2329.
    HOGENOMi HOG000008026.
    KOi K07145.
    OMAi FRESHSH.
    OrthoDBi EOG6GTZMS.

    Enzyme and pathway databases

    BioCyci LMON552536:GIW4-2191-MONOMER.

    Family and domain databases

    HAMAPi MF_01272. Heme_degrading_monooxygenase.
    InterProi IPR007138. ABM-like.
    IPR011008. Dimeric_a/b-barrel.
    IPR023953. IsdG.
    [Graphical view ]
    Pfami PF03992. ABM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54909. SSF54909. 1 hit.
    PROSITEi PS51725. ABM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of lineage III Listeria monocytogenes strain HCC23."
      Steele C.L., Donaldson J.R., Paul D., Banes M.M., Arick T., Bridges S.M., Lawrence M.L.
      J. Bacteriol. 193:3679-3680(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HCC23.

    Entry informationi

    Entry nameiHDOX_LISMH
    AccessioniPrimary (citable) accession number: B8DCJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3