B8DCI2 (B8DCI2_LISMH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase 3 HAMAP MF_00222
EC=1.1.1.25 HAMAP MF_00222

Gene names

Name:	aroE EMBL ACK40485.1
Synonyms:	aroE3 HAMAP MF_00222
Ordered Locus Names:	LMHCC_2147

Organism

Listeria monocytogenes serotype 4a (strain HCC23) [Complete proteome] [HAMAP] EMBL ACK40485.1

Taxonomic identifier

552536 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family. HAMAP MF_00222

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00222
Ligand	NADP HAMAP MF_00222
Molecular function	Oxidoreductase HAMAP MF_00222 EMBL ACK40485.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	137 – 141	5	NADP By similarity HAMAP MF_00222
Sites
	Active site	77	1	Proton acceptor By similarity HAMAP MF_00222

Sequences

	Sequence		Length	Mass (Da)
	B8DCI2 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 8D038120D5511E99	FASTA	291	32,138
	10 20 30 40 50 60 MTNKITERIT GHTELIGLIA TPIRHSLSPT MHNEAFAKLG LDYVYLAFEV GDKELKDVVQ 70 80 90 100 110 120 GFRAMNLRGW NVSMPNKTNI HKYLDKLSPA AELVGAVNTV VNDDGVLTGH ITDGTGYMRA 130 140 150 160 170 180 LKEAGNDIIG KKMTICGAGG AATAICIQAA LDGVKEISIF NRKDDFYANA EKTVEKINSK 190 200 210 220 230 240 TDCKAQLFDI EDHEQLRKEI AESVIFTNAT GVGMKPFEGE TLLPSADMLR PELIVSDVVY 250 260 270 280 290 KPTKTRLLEI AEEQGCQTLN GLGMMLWQGA KAFEIWTHKE MPVDYIKEIL F

References

[1]	"Genome sequence of lineage III Listeria monocytogenes strain HCC23." Steele C.L., Donaldson J.R., Paul D., Banes M.M., Arick T., Bridges S.M., Lawrence M.L. J. Bacteriol. 193:3679-3680(2011) [PubMed: 21602330] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HCC23.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001175 Genomic DNA. Translation: ACK40485.1.
RefSeq	YP_002351099.1. NC_011660.1.
3D structure databases
ProteinModelPortal	B8DCI2.
ModBase	Search...
Protein-protein interaction databases
STRING	B8DCI2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7079495.
GenomeReviews	Gene locus LMHCC_2147 in contig CP001175_GR.
KEGG	lmh:LMHCC_2147.
PATRIC	20319422. VBILisMon86872_2134.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553408.
OMA	SIYIDAT.
ProtClustDB	PRK00258.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B8DCI2_LISMH

Accession

Primary (citable) accession number: B8DCI2

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)