B8DC25 (PANC_LISMH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate synthetase
Short name=PS
EC=6.3.2.1

Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme

Gene names

Name:	panC
Ordered Locus Names:	LMHCC_0656

Organism

Listeria monocytogenes serotype 4a (strain HCC23) [Complete proteome] [HAMAP]

Taxonomic identifier

552536 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity. HAMAP MF_00158
Catalytic activity	ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP MF_00158
Pathway	Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP MF_00158
Subunit structure	Homodimer By similarity. HAMAP MF_00158
Subcellular location	Cytoplasm Potential HAMAP MF_00158.
Miscellaneous	The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity. HAMAP MF_00158
Sequence similarities	Belongs to the pantothenate synthetase family.

Ontologies

Keywords
Biological process	Pantothenate biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pantothenate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantoate-beta-alanine ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 285	285	Pantothenate synthetase HAMAP MF_00158		PRO_1000123417
Regions
	Nucleotide binding	30 – 37	8	ATP By similarity
	Nucleotide binding	147 – 150	4	ATP By similarity
	Nucleotide binding	184 – 187	4	ATP By similarity
Sites
	Active site	37	1	Proton donor By similarity
	Binding site	61	1	Beta-alanine By similarity
	Binding site	61	1	Pantoate By similarity
	Binding site	153	1	Pantoate By similarity
	Binding site	176	1	ATP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8DC25 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: BEE400485276E8AF	FASTA	285	32,080
	10 20 30 40 50 60 MLIIRNKQDL KEAILKQKQA NKTIGYVPTM GFLHEGHMTL VSHARKETDF VVMSVFVNPT 70 80 90 100 110 120 QFGPNEDFDA YPRDEAHDAK LAEEGGVDIL FVPTVEEIYP TELATKLHVT KRVSVLDGAD 130 140 150 160 170 180 REGHFDGVVT VLTKLFHLVN PDNAYFGQKD AQQVAVVSGL VEDYFFPINL RIIATVREAD 190 200 210 220 230 240 GLAKSSRNVY LTEKERKEAP VIHEALLLGR ELIESGETNE AKIVQVMTDK INEQPSHENI 250 260 270 280 AYLALYSYPE FTPVTDWTKG IIIAAAVKYS KARLIDNELI NVKRR

References

[1]	"Genome sequence of lineage III Listeria monocytogenes strain HCC23." Steele C.L., Donaldson J.R., Paul D., Banes M.M., Arick T., Bridges S.M., Lawrence M.L. J. Bacteriol. 193:3679-3680(2011) [PubMed: 21602330] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HCC23.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001175 Genomic DNA. Translation: ACK39011.1.
RefSeq	YP_002349625.1. NC_011660.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B8DC25.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7079033.
GenomeReviews	Gene locus LMHCC_0656 in contig CP001175_GR.
KEGG	lmh:LMHCC_0656.
PATRIC	20316380. VBILisMon86872_0649.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG428839.
OMA	EMDGLAM.
ProtClustDB	PRK00380.
Family and domain databases
HAMAP	MF_00158. PanC. [Tree]
InterPro	IPR004821. Cyt_trans-rel. IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01918.
PANTHER	PTHR21299:SF1. Pantoate_ligase. 1 hit.
Pfam	PF02569. Pantoate_ligase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00125. Cyt_tran_rel. 1 hit. TIGR00018. PanC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PANC_LISMH

Accession

Primary (citable) accession number: B8DC25

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program