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Protein

Cardiolipin synthase

Gene

cls

Organism
Listeria monocytogenes serotype 4a (strain HCC23)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 Phosphatidylglycerol = diphosphatidylglycerol + glycerol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei222 – 2221UniRule annotation
Active sitei224 – 2241UniRule annotation
Active sitei229 – 2291UniRule annotation
Active sitei400 – 4001UniRule annotation
Active sitei402 – 4021UniRule annotation
Active sitei407 – 4071UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciLMON552536:GIW4-93-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthaseUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:cls
Ordered Locus Names:LMHCC_0097
OrganismiListeria monocytogenes serotype 4a (strain HCC23)
Taxonomic identifieri552536 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalUniRule annotationAdd
BLAST
Transmembranei34 – 5421HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 482482Cardiolipin synthasePRO_1000124269Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini217 – 24428PLD phosphodiesterase 1UniRule annotationAdd
BLAST
Domaini395 – 42228PLD phosphodiesterase 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily.UniRule annotation
Contains 2 PLD phosphodiesterase domains.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000077402.
KOiK06131.
OMAiYDITIAK.
OrthoDBiEOG6Q2ST0.

Family and domain databases

HAMAPiMF_01916. Cardiolipin_synth_Cls.
InterProiIPR030874. Cardiolipin_synth_Firmi.
IPR022924. Cardiolipin_synthase.
IPR027379. CLS_N.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
PF13396. PLDc_N. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
TIGRFAMsiTIGR04265. bac_cardiolipin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8DBK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLAYLLVI LLILNVFFAA VTVFLERRDT SATWAWLLVL TFVPIFGFII
60 70 80 90 100
YLIFGRKLSG KKIFDWKGQE KIGIQESTAN QIEMIRQKEF PFSDPNVKKH
110 120 130 140 150
RDLIYLLLVN DGAILTQDNE VELFVDGHEK FDALIADIEN AKDHIHLIYY
160 170 180 190 200
IFHSDELGNR LMRVLERKAA EGLNVKIIYD AMGSRTTKKS FFRTFQKNGG
210 220 230 240 250
LVRPFFPSKL PLINFRLNYR NHRKLAIIDG DVGYIGGFNI GDEYLGASKK
260 270 280 290 300
FGYWRDTHLR VHGKAVYAMQ TRFIMDWNSA SSTHKIDYKA RYFPTFHGKG
310 320 330 340 350
HTSMQIVSSG PDSEWQQIKN GYIKMINAAK KTIYLQSPYF IPDASLLEAI
360 370 380 390 400
KIAALSGVDV RVMIPNKPDH AFVYRATTNY AGELMETGAK IFIYDNGFIH
410 420 430 440 450
AKTLVVDGEI ASVGTANMDF RSFRLNFEVN AFIYEKQMVQ KLEDAFLEDI
460 470 480
LKSYQLTPEL YAKRSLWIKF KEAVSRLLSP IL
Length:482
Mass (Da):55,348
Last modified:March 3, 2009 - v1
Checksum:iE40E2ACED650756A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001175 Genomic DNA. Translation: ACK38459.1.
RefSeqiWP_003729224.1. NC_011660.1.

Genome annotation databases

EnsemblBacteriaiACK38459; ACK38459; LMHCC_0097.
KEGGilmh:LMHCC_0097.
PATRICi20315216. VBILisMon86872_0093.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001175 Genomic DNA. Translation: ACK38459.1.
RefSeqiWP_003729224.1. NC_011660.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACK38459; ACK38459; LMHCC_0097.
KEGGilmh:LMHCC_0097.
PATRICi20315216. VBILisMon86872_0093.

Phylogenomic databases

HOGENOMiHOG000077402.
KOiK06131.
OMAiYDITIAK.
OrthoDBiEOG6Q2ST0.

Enzyme and pathway databases

BioCyciLMON552536:GIW4-93-MONOMER.

Family and domain databases

HAMAPiMF_01916. Cardiolipin_synth_Cls.
InterProiIPR030874. Cardiolipin_synth_Firmi.
IPR022924. Cardiolipin_synthase.
IPR027379. CLS_N.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 2 hits.
PF13396. PLDc_N. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
TIGRFAMsiTIGR04265. bac_cardiolipin. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of lineage III Listeria monocytogenes strain HCC23."
    Steele C.L., Donaldson J.R., Paul D., Banes M.M., Arick T., Bridges S.M., Lawrence M.L.
    J. Bacteriol. 193:3679-3680(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HCC23.

Entry informationi

Entry nameiCLS_LISMH
AccessioniPrimary (citable) accession number: B8DBK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: November 11, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.