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B8D8J3

- PUR9_BUCA5

UniProt

B8D8J3 - PUR9_BUCA5

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, BUAP5A_030
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain 5A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciBAPH563178:GHDF-30-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:BUAP5A_030
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain 5A)
Taxonomic identifieri563178 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000006904: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000122950Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi107806.BU031.

Structurei

3D structure databases

ProteinModelPortaliB8D8J3.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B8D8J3-1 [UniParc]FASTAAdd to Basket

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MPSNNLIKNA LISVSDKKNI VEVAEKLIIN KINLFSTGGT AQILKKNNIP    50
VTEISDYTKF PEIMDGRVKT LHPKIMGGIL GQKQKDQEIM KLYNICPIDI 100
VIVNFYPFEK IKNIKKNDID NVVNNIDIGG PTLVRASAKN YKNVIVIVDL 150
DDFQSTIDSI NNNTMNIEKR FNLASKAFEY TSYYEQIISQ YFIEQNSLYK 200
KTNNSLFPNE INFSFIKKQD LRYGENYHQK SSFYIEKNMC DSGTISTACQ 250
IQGKTLSYNN ISDSDIALEC VKQFTKPACV IVKHGNPCSV AVSHNILESY 300
LSAYNSDPIS AFGGIISFNC KLDEKTAQTI INQQFVEVII IPEISKKAVK 350
ILQKKQNIRV LVTGKLQNNT VGLDLKKITN GLLVQEYDSH NIDYNSWSFV 400
TKRSPTKKEL KDSIFCWQVA KFVKSNAIVY GSDEITIGIG AGQMSRIYST 450
KLANIKVKDQ GKNIIGATMA SDAFFPFRDG IDEAASVGIS SIIQPGGSIR 500
DEEIIRAADE HNITMIFTKK RHFKH 525
Length:525
Mass (Da):59,036
Last modified:March 3, 2009 - v1
Checksum:i95AE0B6FA3DF5822
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001161 Genomic DNA. Translation: ACL30415.1.
RefSeqiWP_009873991.1. NC_011833.1.
YP_002467802.1. NC_011833.1.

Genome annotation databases

EnsemblBacteriaiACL30415; ACL30415; BUAP5A_030.
GeneIDi7262376.
KEGGibap:BUAP5A_030.
PATRICi21242281. VBIBucAph51993_0030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001161 Genomic DNA. Translation: ACL30415.1 .
RefSeqi WP_009873991.1. NC_011833.1.
YP_002467802.1. NC_011833.1.

3D structure databases

ProteinModelPortali B8D8J3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 107806.BU031.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL30415 ; ACL30415 ; BUAP5A_030 .
GeneIDi 7262376.
KEGGi bap:BUAP5A_030.
PATRICi 21242281. VBIBucAph51993_0030.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci BAPH563178:GHDF-30-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The dynamics and time scale of ongoing genomic erosion in symbiotic bacteria."
    Moran N.A., McLaughlin H.J., Sorek R.
    Science 323:379-382(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 5A.

Entry informationi

Entry nameiPUR9_BUCA5
AccessioniPrimary (citable) accession number: B8D8J3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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