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B8D8D5 (MTLD_BUCA5) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17
Gene names
Name:mtlD
Ordered Locus Names:BUAP5A_564
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain 5A) [Complete proteome] [HAMAP]
Taxonomic identifier563178 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol-1-phosphate 5-dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 385385Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196
PRO_1000124385

Regions

Nucleotide binding3 – 1412NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
B8D8D5 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 7D131BF6EA5875D8

FASTA38543,857
        10         20         30         40         50         60 
MKALQFGAGN IGRGFIGKTL SESGFSVIFS DVNQNIVDAI NYNREYFVKI IGSNQNKTVN 

        70         80         90        100        110        120 
IKRVSAINSN DSNIKKIISS VDLITTAVGP TALEKIALII TQGIIFKIKN QFTKPLNIIA 

       130        140        150        160        170        180 
CENKIKSSSF LKQVVLKNLP IKYHDYLNKY IGFIDCSIDT IIPSINNKDD LFLTVEEFKE 

       190        200        210        220        230        240 
WIVNINQFKG AVLKIVDMKF SNNLDAFIER KLFTLNTGHA IAAYLGLIKN YKTIQDAISD 

       250        260        270        280        290        300 
KKIRVIVRSA MEESGSVLIK RYNFNKNDHL DYIEKIFLRF ENPFLSDKLE RIGRNPLQKL 

       310        320        330        340        350        360 
RREDRLIKPF LGAFEYNLPY SNLAKGIAAA FYYHNKNDLE SIELSSSIKK QGLESTIIKI 

       370        380 
CDLPVNSKEV YSIILEYNLI KKIIR

« Hide

References

[1]"The dynamics and time scale of ongoing genomic erosion in symbiotic bacteria."
Moran N.A., McLaughlin H.J., Sorek R.
Science 323:379-382(2009) [PubMed: 19150844] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 5A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001161 Genomic DNA. Translation: ACL30911.1.
RefSeqYP_002468299.1. NC_011833.1.

3D structure databases

ProteinModelPortalB8D8D5.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8D8D5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000000701; EBBUCP00000000656; EBBUCG00000000701.
GeneID7262326.
GenomeReviewsGene locus BUAP5A_564 in contig CP001161_GR.
KEGGbap:BUAP5A_564.
PATRIC21243395. VBIBucAph51993_0558.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000007918.
OMAWIVNINQ.
ProtClustDBPRK02318.

Family and domain databases

HAMAPMF_00196. Mannitol_dehydrog.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00009.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_BUCA5
AccessionPrimary (citable) accession number: B8D8D5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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