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B8D8B4 (ILVC_BUCAT) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase
EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:BUAPTUC7_592
OrganismBuchnera aphidicola subsp. Acyrthosiphon pisum (strain Tuc7) [Complete proteome] [HAMAP]
Taxonomic identifier561501 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490Ketol-acid reductoisomerase HAMAP MF_00435
PRO_1000190918

Sites

Active site1311 Potential

Sequences

Sequence LengthMass (Da)Tools
B8D8B4 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 0C108D0AF1476504

FASTA49055,828
        10         20         30         40         50         60 
MNYFNTLNFT QKINQINKCR FMKKEEFNKK NDILKNKNIV IVGCGAQGLN QGLNMRDAGL 

        70         80         90        100        110        120 
NISYALKKNS IANKNQSWIN AIENNFKVDD YDALIPDADL VINLTPDKQH HSVIKKLQKL 

       130        140        150        160        170        180 
MKKNAVLGYS HGFNIVEFGE KIRKDITVIM VAPKCPGTEV REEYKRGFGV PTLIAVHHEN 

       190        200        210        220        230        240 
DINKIGLEVA KAWAFSTGGH RAGVLESSFI AEVKSDLMGE QTILCGMLQT ASLLCYEKLI 

       250        260        270        280        290        300 
TEKCNPAYSA KLIQNGWETI TESLKHGGIT LMMDRLSNSS KIRAYKLSKE IKKILSPLFQ 

       310        320        330        340        350        360 
KHMDDIISGE FSNEMMKDWE NQDLKLLNWR YKTKNTSFET APVYNEKIPE QEYYDHGILM 

       370        380        390        400        410        420 
IAILKSGIEL SFEKMIETGI KEESAYYESL HELPLIANTI ARKKLYEMNK VISDTAEYGS 

       430        440        450        460        470        480 
YLFSESAYPI LKEFISTLNK SDLGCALSHQ SVNNIELYRI NQKIQNHPIE IIGCTLRNYM 

       490 
KKMKAITVAK

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References

[1]"The dynamics and time scale of ongoing genomic erosion in symbiotic bacteria."
Moran N.A., McLaughlin H.J., Sorek R.
Science 323:379-382(2009) [PubMed: 19150844] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuc7.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001158 Genomic DNA. Translation: ACL30379.1.
RefSeqYP_002468874.1. NC_011834.1.

3D structure databases

ProteinModelPortalB8D8B4.
SMRB8D8B4. Positions 2-488.
ModBaseSearch...

Protein-protein interaction databases

STRINGB8D8B4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBUCT00000001998; EBBUCP00000001868; EBBUCG00000001998.
GeneID7263233.
GenomeReviewsGene locus BUAPTUC7_592 in contig CP001158_GR.
KEGGbau:BUAPTUC7_592.
PATRIC21249303. VBIBucAph26317_0585.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000007925.
HOGENOMHBG297205.
OMAEKHMDDI.
ProtClustDBPRK05225.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
IPR014359. KetolA_reductoisomerase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PTHR21371:SF2. PTHR21371:SF2. 1 hit.
PfamPF01450. IlvC. 2 hits.
PF07991. IlvN. 1 hit.
[Graphical view]
PIRSFPIRSF000116. IlvC_gammaproteo. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 2 hits.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_BUCAT
AccessionPrimary (citable) accession number: B8D8B4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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