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B8D7P8

- PNCB_BUCAT

UniProt

B8D7P8 - PNCB_BUCAT

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain Tuc7)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: InterPro

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciBAPH561501:GHRN-353-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:BUAPTUC7_355
    OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain Tuc7)
    Taxonomic identifieri561501 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
    ProteomesiUP000002455: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 399399Nicotinate phosphoribosyltransferasePRO_1000146837Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi561501.BUAPTUC7_355.

    Structurei

    3D structure databases

    ProteinModelPortaliB8D7P8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    HOGENOMiHOG000284928.
    KOiK00763.
    OMAiQAVFHRY.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8D7P8-1 [UniParc]FASTAAdd to Basket

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    MKRYDYPIVK TLLDTDAYKL HMQQAVFYHY KNVNVVAEFL CRGDNFLGCY    50
    ANILLDQISM MRSLSLSHEE YVYMTSFPFF KKEYLHWLKK FRYNVSQVKI 100
    NSYQGRLHIR ISGLWKEVIL WEVPILALIS EVFHGNFSPE ITSQSALQYL 150
    DIKLKKFFNR TKYIDLSHLK IVDFGTRRRF SYDVQYSIVK RLKESFPFLI 200
    GSSNYHIARI LKIKPVGTQA HEWFQAHQQI GSNLKNSQIL ALQKWLYQYK 250
    NHLGIALTDS ITMDAFLDDF NLHFASFYQG IRHDSGDPVK WGEKALKHYE 300
    KLGIDPCTKT LLFSDNLDFK KIISLYKKFH KKINVIFGIG TKLTCDIPYV 350
    KPLNIVIKLV ECNGKPVAKI SDSPGKTFCL DRIFLKNLCQ VFNVSLKNR 399
    Length:399
    Mass (Da):46,751
    Last modified:March 3, 2009 - v1
    Checksum:i09A735641222EE19
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001158 Genomic DNA. Translation: ACL30163.1.
    RefSeqiYP_002468658.1. NC_011834.1.

    Genome annotation databases

    EnsemblBacteriaiACL30163; ACL30163; BUAPTUC7_355.
    GeneIDi7262970.
    KEGGibau:BUAPTUC7_355.
    PATRICi21248809. VBIBucAph26317_0356.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001158 Genomic DNA. Translation: ACL30163.1 .
    RefSeqi YP_002468658.1. NC_011834.1.

    3D structure databases

    ProteinModelPortali B8D7P8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 561501.BUAPTUC7_355.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL30163 ; ACL30163 ; BUAPTUC7_355 .
    GeneIDi 7262970.
    KEGGi bau:BUAPTUC7_355.
    PATRICi 21248809. VBIBucAph26317_0356.

    Phylogenomic databases

    eggNOGi COG1488.
    HOGENOMi HOG000284928.
    KOi K00763.
    OMAi QAVFHRY.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci BAPH561501:GHRN-353-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The dynamics and time scale of ongoing genomic erosion in symbiotic bacteria."
      Moran N.A., McLaughlin H.J., Sorek R.
      Science 323:379-382(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuc7.

    Entry informationi

    Entry nameiPNCB_BUCAT
    AccessioniPrimary (citable) accession number: B8D7P8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3