B8D7P8 (PNCB_BUCAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nicotinate phosphoribosyltransferase
Short name=NAPRTase
EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	BUAPTUC7_355

Organism

Buchnera aphidicola subsp. Acyrthosiphon pisum (strain Tuc7) [Complete proteome] [HAMAP]

Taxonomic identifier

561501 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera › Buchnera aphidicola › Buchnera aphidicola (Acyrthosiphon pisum)

Protein attributes

Sequence length	399 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP nicotinate-nucleotide diphosphorylase (carboxylating) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 399	399	Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570		PRO_1000146837

Sequences

	Sequence		Length	Mass (Da)
	B8D7P8 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 09A735641222EE19	FASTA	399	46,751
	10 20 30 40 50 60 MKRYDYPIVK TLLDTDAYKL HMQQAVFYHY KNVNVVAEFL CRGDNFLGCY ANILLDQISM 70 80 90 100 110 120 MRSLSLSHEE YVYMTSFPFF KKEYLHWLKK FRYNVSQVKI NSYQGRLHIR ISGLWKEVIL 130 140 150 160 170 180 WEVPILALIS EVFHGNFSPE ITSQSALQYL DIKLKKFFNR TKYIDLSHLK IVDFGTRRRF 190 200 210 220 230 240 SYDVQYSIVK RLKESFPFLI GSSNYHIARI LKIKPVGTQA HEWFQAHQQI GSNLKNSQIL 250 260 270 280 290 300 ALQKWLYQYK NHLGIALTDS ITMDAFLDDF NLHFASFYQG IRHDSGDPVK WGEKALKHYE 310 320 330 340 350 360 KLGIDPCTKT LLFSDNLDFK KIISLYKKFH KKINVIFGIG TKLTCDIPYV KPLNIVIKLV 370 380 390 ECNGKPVAKI SDSPGKTFCL DRIFLKNLCQ VFNVSLKNR

References

[1]	"The dynamics and time scale of ongoing genomic erosion in symbiotic bacteria." Moran N.A., McLaughlin H.J., Sorek R. Science 323:379-382(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuc7.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001158 Genomic DNA. Translation: ACL30163.1.
RefSeq	YP_002468658.1. NC_011834.1.
3D structure databases
ProteinModelPortal	B8D7P8.
ModBase	Search...
Protein-protein interaction databases
STRING	561501.BUAPTUC7_355.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACL30163; ACL30163; BUAPTUC7_355.
GeneID	7262970.
KEGG	bau:BUAPTUC7_355.
PATRIC	21248809. VBIBucAph26317_0356.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1488.
HOGENOM	HOG000284928.
KO	K00763.
OMA	SFGWGTN.
ProtClustDB	PRK05321.
Enzyme and pathway databases
BioCyc	BAPH561501:GHRN-352-MONOMER.
UniPathway	UPA00253; UER00457.
Family and domain databases
HAMAP	MF_00570. NAPRTase.
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR002638. Quinolinate_PRibosylTrfase_C. [Graphical view]
PANTHER	PTHR11098:SF1. PTHR11098:SF1. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
SUPFAM	SSF51690. Q_phspho_trans. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_BUCAT

Accession

Primary (citable) accession number: B8D7P8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program