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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain Tuc7)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.UniRule annotation

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 6-phosphogluconolactonase (pgl)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

BioCyciBAPH561501:G1GCT-301-MONOMER
UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonaseUniRule annotation (EC:3.1.1.31UniRule annotation)
Short name:
6-P-gluconolactonaseUniRule annotation
Gene namesi
Name:pglUniRule annotation
Ordered Locus Names:BUAPTUC7_289
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain Tuc7)
Taxonomic identifieri561501 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001858341 – 3346-phosphogluconolactonaseAdd BLAST334

Structurei

3D structure databases

ProteinModelPortaliB8D7I7
SMRiB8D7I7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000257418
KOiK07404
OMAiEGNWPRD

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_01605 6P_gluconolactonase, 1 hit
InterProiView protein in InterPro
IPR022528 6-phosphogluconolactonase_YbhE
IPR019405 Lactonase_7-beta_prop
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF10282 Lactonase, 1 hit

Sequencei

Sequence statusi: Complete.

B8D7I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQVVYIANS ESKNIEVWNL CKSGKMNLIQ KIETDGKIQP INIIQKRNLL
60 70 80 90 100
YAGIFPDNKI ITYSINHNGF LEKKNESNIP GKANYISFDK KKEFLFCSSY
110 120 130 140 150
HSNFISVSPL NKFGIPQNPI QIIYNIEGCH AAKMNYKYNI LFVISLKEDC
160 170 180 190 200
IYLYYLTDFG ILKSTEQNIL HTQKKSGPRH IIFHPNQDFI YTINELNGTI
210 220 230 240 250
DVWKIYKKNN VIKVKNIQNI HVLKNRFLKD YWCSDIHITS CGRFLYACDR
260 270 280 290 300
FFNIISLFHI NQNDNKLVFF KSYDTEEQPR SFNINSHNTH LIVAGEKSNT
310 320 330
FIIYGISNST GELKKINVYS TGQRPVWILI HALC
Length:334
Mass (Da):38,917
Last modified:March 3, 2009 - v1
Checksum:i917BD56378B0485C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001158 Genomic DNA Translation: ACL30102.1
RefSeqiWP_012619495.1, NC_011834.1

Genome annotation databases

EnsemblBacteriaiACL30102; ACL30102; BUAPTUC7_289
KEGGibau:BUAPTUC7_289

Similar proteinsi

Entry informationi

Entry namei6PGL_BUCAT
AccessioniPrimary (citable) accession number: B8D7I7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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