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Protein

Phosphoheptose isomerase

Gene

gmhA

Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain Tuc7)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.UniRule annotation

Catalytic activityi

D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: D-glycero-D-manno-heptose 7-phosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Phosphoheptose isomerase (gmhA)
This subpathway is part of the pathway D-glycero-D-manno-heptose 7-phosphate biosynthesis, which is itself part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate, the pathway D-glycero-D-manno-heptose 7-phosphate biosynthesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61ZincUniRule annotation1
Metal bindingi65ZincUniRule annotation1
Binding sitei65SubstrateUniRule annotation1
Binding sitei124SubstrateUniRule annotation1
Metal bindingi172ZincUniRule annotation1
Binding sitei172SubstrateUniRule annotation1
Metal bindingi180ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00041; UER00436.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoheptose isomeraseUniRule annotation (EC:5.3.1.28UniRule annotation)
Alternative name(s):
Sedoheptulose 7-phosphate isomeraseUniRule annotation
Gene namesi
Name:gmhAUniRule annotation
Ordered Locus Names:BUAPTUC7_247
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain Tuc7)
Taxonomic identifieri561501 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesErwiniaceaeBuchnera

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001969911 – 193Phosphoheptose isomeraseAdd BLAST193

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB8D7E7.
SMRiB8D7E7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 193SISUniRule annotationAdd BLAST157

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 54Substrate bindingUniRule annotation3
Regioni93 – 94Substrate bindingUniRule annotation2
Regioni119 – 121Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the SIS family. GmhA subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000237571.
KOiK03271.
OMAiFLAHKEA.

Family and domain databases

CDDicd05006. SIS_GmhA. 1 hit.
HAMAPiMF_00067. GmhA. 1 hit.
InterProiView protein in InterPro
IPR035461. GmhA/DiaA.
IPR004515. Phosphoheptose_Isoase.
IPR001347. SIS.
PfamiView protein in Pfam
PF13580. SIS_2. 1 hit.
TIGRFAMsiTIGR00441. gmhA. 1 hit.
PROSITEiView protein in PROSITE
PS51464. SIS. 1 hit.

Sequencei

Sequence statusi: Complete.

B8D7E7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKKIIFSEF NSASKILKNF LEDKKQIENI QKAAILIAQS FKNEKKVISC
60 70 80 90 100
GNGGSHCDAV HFSEELTSVY RKKRSGYPAI SISDSSYISA VGNDFGYDQI
110 120 130 140 150
FSRFIQSVGH LGDILLAIST SGNSLNIVRA IEEAKKKKMK VIVLTGNNAG
160 170 180 190
KIKNLSDIEI CIPHCGYSDR IQEMHIKIIH ILILIIEKEM QKN
Length:193
Mass (Da):21,610
Last modified:March 3, 2009 - v1
Checksum:i7DB396B8DDF736E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001158 Genomic DNA. Translation: ACL30062.1.
RefSeqiWP_009874204.1. NC_011834.1.

Genome annotation databases

EnsemblBacteriaiACL30062; ACL30062; BUAPTUC7_247.
KEGGibau:BUAPTUC7_247.

Similar proteinsi

Entry informationi

Entry nameiGMHA_BUCAT
AccessioniPrimary (citable) accession number: B8D7E7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: August 30, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families