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B8D6W2

- ASSY_BUCAT

UniProt

B8D6W2 - ASSY_BUCAT

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Protein
Argininosuccinate synthase
Gene
argG, BUAPTUC7_050
Organism
Buchnera aphidicola subsp. Acyrthosiphon pisum (strain Tuc7)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei91 – 911Citrulline By similarity
Binding sitei121 – 1211ATP; via amide nitrogen By similarity
Binding sitei123 – 1231Aspartate By similarity
Binding sitei127 – 1271Aspartate By similarity
Binding sitei127 – 1271Citrulline By similarity
Binding sitei128 – 1281Aspartate By similarity
Binding sitei131 – 1311Citrulline By similarity
Binding sitei180 – 1801Citrulline By similarity
Binding sitei189 – 1891Citrulline By similarity
Binding sitei265 – 2651Citrulline By similarity
Binding sitei277 – 2771Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 209ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAPH561501:GHRN-49-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:BUAPTUC7_050
OrganismiBuchnera aphidicola subsp. Acyrthosiphon pisum (strain Tuc7)
Taxonomic identifieri561501 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeBuchnera
ProteomesiUP000002455: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Argininosuccinate synthaseUniRule annotation
PRO_1000191886Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi561501.BUAPTUC7_050.

Structurei

3D structure databases

ProteinModelPortaliB8D6W2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8D6W2-1 [UniParc]FASTAAdd to Basket

« Hide

MIRKKNNKVV LAYSGGLDTS AIIPWLKENY NFEVVAFVAD IGQSKKDLNG    50
IEKKSLESGA SSCHVFDLKE EFIENYVYPV LKTGALYEGS YLLGTAMARP 100
IIAKKQVELA LNIGANSLCH GATGKGNDQV RFEMAYAALA PNLNVIAPWR 150
EWNLNSRESL LKYLDKKNIS TTATLEKIYS KDENSWHIST EGGLLENPWN 200
QSNEDCWSWT VNPEDAPEKP EYVSLQLKEG CVVSVNNQKL NPLKCVEELN 250
SLGAKHGIGR IDIIENRLIG MKSRGCYETP GGTIIMTAIK AIEQLVLDRE 300
SFRWREKIGL EMSSIVYDGR WFSPIRKSLQ AAADSLSLEI TGEVILKLYK 350
GSVTAVQKKS PNSLYSEEYA TFGEDKVYKQ SDADGFIRLF SLSSKIRAQN 400
MLK 403
Length:403
Mass (Da):45,073
Last modified:March 3, 2009 - v1
Checksum:iF23B7024C8BDB147
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001158 Genomic DNA. Translation: ACL29877.1.
RefSeqiYP_002468372.1. NC_011834.1.

Genome annotation databases

EnsemblBacteriaiACL29877; ACL29877; BUAPTUC7_050.
GeneIDi7263395.
KEGGibau:BUAPTUC7_050.
PATRICi21248165. VBIBucAph26317_0045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001158 Genomic DNA. Translation: ACL29877.1 .
RefSeqi YP_002468372.1. NC_011834.1.

3D structure databases

ProteinModelPortali B8D6W2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 561501.BUAPTUC7_050.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL29877 ; ACL29877 ; BUAPTUC7_050 .
GeneIDi 7263395.
KEGGi bau:BUAPTUC7_050.
PATRICi 21248165. VBIBucAph26317_0045.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci BAPH561501:GHRN-49-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The dynamics and time scale of ongoing genomic erosion in symbiotic bacteria."
    Moran N.A., McLaughlin H.J., Sorek R.
    Science 323:379-382(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuc7.

Entry informationi

Entry nameiASSY_BUCAT
AccessioniPrimary (citable) accession number: B8D6W2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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