B8D641 (B8D641_DESK1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Triosephosphate isomerase HAMAP-Rule MF_00147
Short name=TIM HAMAP-Rule MF_00147
EC=5.3.1.1 HAMAP-Rule MF_00147

Alternative name(s):
Triose-phosphate isomerase HAMAP-Rule MF_00147

Gene names

Name:	tpiA HAMAP-Rule MF_00147
Ordered Locus Names:	DKAM_1246

Organism

Desulfurococcus kamchatkensis (strain 1221n / DSM 18924) [Complete proteome] [HAMAP] EMBL ACL11572.1

Taxonomic identifier

490899 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Desulfurococcus › Desulfurococcus kamchatkensis

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP-Rule MF_00147 RuleBase RU000517
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP-Rule MF_00147 RuleBase RU000517 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP-Rule MF_00147 RuleBase RU000517
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_00147
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00147.
Sequence similarities	Belongs to the triosephosphate isomerase family. HAMAP-Rule MF_00147

Ontologies

Keywords
Biological process	Gluconeogenesis HAMAP-Rule MF_00147 RuleBase RU003527 Glycolysis HAMAP-Rule MF_00147 RuleBase RU003527 Pentose shunt HAMAP-Rule MF_00147 RuleBase RU003527
Cellular component	Cytoplasm HAMAP-Rule MF_00147
Molecular function	Isomerase HAMAP-Rule MF_00147 RuleBase RU000517 EMBL ACL11572.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP pentose-phosphate shunt Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	triose-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	97	1	Electrophile By similarity HAMAP-Rule MF_00147
	Active site	145	1	Proton acceptor By similarity HAMAP-Rule MF_00147
	Binding site	9	1	Substrate By similarity HAMAP-Rule MF_00147
	Binding site	11	1	Substrate By similarity HAMAP-Rule MF_00147

Sequences

	Sequence		Length	Mass (Da)
	B8D641 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 86E55AF3285AB8EA	FASTA	231	24,578
	10 20 30 40 50 60 MVKPVLAVNF KAYYPHSFGE NAYRLAKDAV RVWRETGVEV ILAPPFTELK SVIEAVKDTG 70 80 90 100 110 120 VKVFAQHADP VEPGAITGFI PLEGLKNLGA HGVILNHSEH RLKISDINYL VKKARRLGIE 130 140 150 160 170 180 TLVCADTPET GAAVAVLGPD MVAVEPPELI GTGVSVSKAK PEVVTNSVDM IRRVNKDVAI 190 200 210 220 230 LTGAGITTGE DAYIAVKLGT IGVLVASGIV KAKDPYQVMK EMAEAMLKGL A

References

[1]

"Complete genome sequence of the anaerobic, protein-degrading hyperthermophilic crenarchaeon Desulfurococcus kamchatkensis." Ravin N.V., Mardanov A.V., Beletsky A.V., Kublanov I.V., Kolganova T.V., Lebedinsky A.V., Chernyh N.A., Bonch-Osmolovskaya E.A., Skryabin K.G. J. Bacteriol. 191:2371-2379(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1221n / DSM 18924.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001140 Genomic DNA. Translation: ACL11572.1.
RefSeq	YP_002428939.1. NC_011766.1.
3D structure databases
ProteinModelPortal	B8D641.
ModBase	Search...
Protein-protein interaction databases
STRING	490899.DKAM_1246.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACL11572; ACL11572; DKAM_1246.
GeneID	7171315.
KEGG	dka:DKAM_1246.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0149.
HOGENOM	HOG000223030.
KO	K01803.
OMA	IPVYAQH.
ProtClustDB	PRK00042.
Enzyme and pathway databases
BioCyc	DKAM490899:GHYH-1283-MONOMER.
UniPathway	UPA00109; UER00189. UPA00138.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
HAMAP	MF_00147_A. TIM_A.
InterPro	IPR013785. Aldolase_TIM. IPR000652. Triosephosphate_isomerase. IPR022891. Triosephosphate_isomerase_arc. IPR020861. Triosephosphate_isomerase_AS. [Graphical view]
PANTHER	PTHR21139. PTHR21139. 1 hit.
Pfam	PF00121. TIM. 1 hit. [Graphical view]
SUPFAM	SSF51351. Triophos_ismrse. 1 hit.
TIGRFAMs	TIGR00419. tim. 1 hit.
PROSITE	PS00171. TIM_1. 1 hit. PS51440. TIM_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B8D641_DESK1

Accession

Primary (citable) accession number: B8D641

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)