B8D5U4 (KCY_DESK1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidylate kinase
Short name=CK
EC=2.7.4.25

Alternative name(s):
Cytidine monophosphate kinase
Short name=CMP kinase

Gene names

Name:	cmk
Ordered Locus Names:	DKAM_1149

Organism

Desulfurococcus kamchatkensis (strain 1221n / DSM 18924) [Complete proteome] [HAMAP]

Taxonomic identifier

490899 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Desulfurococcus

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (d)CMP = ADP + (d)CDP. HAMAP MF_00239
Subcellular location	Cytoplasm By similarity HAMAP MF_00239.
Sequence similarities	Belongs to the cytidylate kinase family. Type 2 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cytidylate kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Cytidylate kinase HAMAP MF_00239		PRO_1000125310
Regions
	Nucleotide binding	8 – 16	9	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8D5U4 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: AE81BD4D8345461A	FASTA	185	20,955
	10 20 30 40 50 60 MVKIVFSGPP GSGKTTQAKR VAEYYGLKYF SAGSLFREYA RRKGVSLEEL SRIALEDPSI 70 80 90 100 110 120 DLEIDRMTLE TVRDSDDIVI DGHLAAWIVS DIVDLKIYVT APLTLRILRV AGRDNTPLGK 130 140 150 160 170 180 ALAETLIREY SQRRRFMEYY GIDIYDTSIF DLTINTKLIG VEEAFNIIKS IIDKILKEKH GSMSE

References

[1]

"Complete genome sequence of the anaerobic, protein-degrading hyperthermophilic crenarchaeon Desulfurococcus kamchatkensis." Ravin N.V., Mardanov A.V., Beletsky A.V., Kublanov I.V., Kolganova T.V., Lebedinsky A.V., Chernyh N.A., Bonch-Osmolovskaya E.A., Skryabin K.G. J. Bacteriol. 191:2371-2379(2009) [PubMed: 19114480] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1221n / DSM 18924.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001140 Genomic DNA. Translation: ACL11475.1.
RefSeq	YP_002428842.1. NC_011766.1.
3D structure databases
ProteinModelPortal	B8D5U4.
ModBase	Search...
Protein-protein interaction databases
STRING	B8D5U4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7171240.
GenomeReviews	Gene locus DKAM_1149 in contig CP001140_GR.
KEGG	dka:DKAM_1149.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG578180.
OMA	CAGFIFR.
ProtClustDB	PRK04182.
Family and domain databases
HAMAP	MF_00239. Cytidyl_kinase_type2. [Tree]
InterPro	IPR000850. Adenylate_kin. IPR011892. Cyt_kin_arch. [Graphical view]
KO	K00945.
Pfam	PF00406. ADK. 1 hit. [Graphical view]
TIGRFAMs	TIGR02173. Cyt_kin_arch. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KCY_DESK1

Accession

Primary (citable) accession number: B8D5U4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 3, 2009
Last modified:	January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program