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Protein

Probable dCTP deaminase

Gene

dcd

Organism
Desulfurococcus kamchatkensis (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable dCTP deaminase (dcd)
  2. no protein annotated in this organism
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:DKAM_1136
OrganismiDesulfurococcus kamchatkensis (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n)
Taxonomic identifieri490899 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeDesulfurococcus
Proteomesi
  • UP000006903 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001231421 – 181Probable dCTP deaminaseAdd BLAST181

Interactioni

Protein-protein interaction databases

STRINGi490899.DKAM_1136.

Structurei

3D structure databases

ProteinModelPortaliB8D5T1.
SMRiB8D5T1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04048. Archaea.
COG0717. LUCA.
HOGENOMiHOG000228601.
KOiK01494.
OMAiGQLCLFR.
OrthoDBiPOG093Z0C6C.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
HAMAPiMF_00146. dCTP_deaminase. 1 hit.
InterProiView protein in InterPro
IPR011962. dCTP_deaminase.
IPR029054. dUTPase-like.
IPR033704. dUTPase_trimeric.
PfamiView protein in Pfam
PF00692. dUTPase. 1 hit.
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

B8D5T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILSDWDIRV YIEKKLLIID PLFDDTVREN GVDLRFGDEF CRFKRENSVV
60 70 80 90 100
DTSRDGVDNV LECYRVRGDG FVINPLEHVL TTTLEYVEFP HDLVGLVNLR
110 120 130 140 150
STFARFGLYI PPTVIDAGFK GNITIELVGS TVPVKVYPGQ RFLHLILART
160 170 180
SSPVYKPYTG KYQGQRGVTP PKLDNSSSKN F
Length:181
Mass (Da):20,561
Last modified:March 3, 2009 - v1
Checksum:iBADAC8807D182653
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001140 Genomic DNA. Translation: ACL11462.1.
RefSeqiWP_012608803.1. NC_011766.1.

Genome annotation databases

EnsemblBacteriaiACL11462; ACL11462; DKAM_1136.
GeneIDi7171228.
KEGGidka:DKAM_1136.

Similar proteinsi

Entry informationi

Entry nameiDCD_DESK1
AccessioniPrimary (citable) accession number: B8D5T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: August 30, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families