B8D4L5 (B8D4L5_DESK1) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Hydroxymethylglutaryl-CoA reductase, degradative EMBL ACL11046.1

Gene names

Ordered Locus Names:

DKAM_0720

Organism

Desulfurococcus kamchatkensis (strain 1221n / DSM 18924) [Complete proteome] [HAMAP]

Taxonomic identifier

490899 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Desulfurococcales › Desulfurococcaceae › Desulfurococcus

Protein attributes

Sequence length	427 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the HMG-CoA reductase family. RuleBase RU004268

Ontologies

Keywords
Molecular function	Oxidoreductase RuleBase RU004269
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro hydroxymethylglutaryl-CoA reductase (NADPH) activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B8D4L5 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 6133ACF941DC6F82	FASTA	427	46,449
	10 20 30 40 50 60 MEKTSRIQGF YKLPLEERRR IVCEWAGLTE EECRTLSEFG NLPVKIGDSM IENVIGAMSY 70 80 90 100 110 120 PFAVATNFLI NGRDYLVPMV IEETSVVAAA SNAARMLRHG KGILANAERQ EMISQIHLVK 130 140 150 160 170 180 VNSPRFKAMK IIEAKKELLD YAAQQDPTLL KYGGGPRDLE VRAMEHPALG GVIIVHLVVD 190 200 210 220 230 240 VRDAMGANTV NTMAEAIAPL LEKITGGEAR LRIVSNHAVY RVTRAWAATP VEEVGGLEVA 250 260 270 280 290 300 RRIMEASILA EIDPYRAVTH NKGIMNGVIA VALATGQDHR AIEAGAHAYA SRTGVYKPLS 310 320 330 340 350 360 YWEVTSDNYL AGSLEIPLQI GVVGGAVKVH PVAKIALKIL GVNTARELAE VMAAVGLAQN 370 380 390 400 410 420 LAALRALVTE GIQKGHMRLH ARNLAIMAGA SGDLIDKIAE KMIRDGRIRY DYAKQLVEKA LQGEPLD

References

[1]

"Complete genome sequence of the anaerobic, protein-degrading hyperthermophilic crenarchaeon Desulfurococcus kamchatkensis." Ravin N.V., Mardanov A.V., Beletsky A.V., Kublanov I.V., Kolganova T.V., Lebedinsky A.V., Chernyh N.A., Bonch-Osmolovskaya E.A., Skryabin K.G. J. Bacteriol. 191:2371-2379(2009) [PubMed: 19114480] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001140 Genomic DNA. Translation: ACL11046.1.
RefSeq	YP_002428413.1. NC_011766.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B8D4L5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7170894.
GenomeReviews	Gene locus DKAM_0720 in contig CP001140_GR.
KEGG	dka:DKAM_0720.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG477902.
OMA	NNKGIMN.
ProtClustDB	CLSK731318.
Family and domain databases
InterPro	IPR002202. HMG_CoA_Rdtase. IPR004553. HMG_CoA_Rdtase_bac-typ. IPR023074. HMG_CoA_Rdtase_cat. IPR023076. HMG_CoA_Rdtase_CS. IPR009023. HMG_CoA_Rdtase_NAD(P)-bd. IPR009029. HMG_CoA_Rdtase_sub-bd. [Graphical view]
Gene3D	G3DSA:3.30.70.420. G3DSA:3.30.70.420. 1 hit. G3DSA:3.90.770.10. HMG-CoA_red. 2 hits.
KO	K00054.
Pfam	PF00368. HMG-CoA_red. 1 hit. [Graphical view]
PRINTS	PR00071. HMGCOARDTASE.
SUPFAM	SSF55035. HMG_CoA_NAD_bind. 1 hit. SSF56542. HMG_CoA_sub_bind. 1 hit.
TIGRFAMs	TIGR00532. HMG_CoA_R_NAD. 1 hit.
PROSITE	PS00066. HMG_COA_REDUCTASE_1. 1 hit. PS01192. HMG_COA_REDUCTASE_3. 1 hit. PS50065. HMG_COA_REDUCTASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B8D4L5_DESK1

Accession

Primary (citable) accession number: B8D4L5

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	November 16, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)