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B8D2P4

- B8D2P4_DESK1

UniProt

B8D2P4 - B8D2P4_DESK1

Protein

Aminomethyltransferase

Gene

DKAM_0299

Organism
Desulfurococcus kamchatkensis (strain 1221n / DSM 18924)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine.UniRule annotation
    The glycine cleavage system catalyzes the degradation of glycine By similarity.

    Catalytic activityi

    [Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.UniRule annotation

    GO - Molecular functioni

    1. aminomethyltransferase activity Source: UniProtKB-EC
    2. transaminase activity Source: UniProtKB-KW

    GO - Biological processi

    1. glycine catabolic process Source: InterPro

    Keywords - Molecular functioni

    AminotransferaseUniRule annotation, MethyltransferaseImported, Transferase

    Enzyme and pathway databases

    BioCyciDKAM490899:GHYH-303-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AminomethyltransferaseUniRule annotation (EC:2.1.2.10UniRule annotation)
    Gene namesi
    Ordered Locus Names:DKAM_0299Imported
    OrganismiDesulfurococcus kamchatkensis (strain 1221n / DSM 18924)Imported
    Taxonomic identifieri490899 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeDesulfurococcus
    ProteomesiUP000006903: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation
    The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

    Protein-protein interaction databases

    STRINGi490899.DKAM_0299.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvT family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0404.
    HOGENOMiHOG000239381.
    KOiK00605.
    OMAiPFFGVQS.

    Family and domain databases

    Gene3Di2.40.30.110. 1 hit.
    3.30.1360.120. 2 hits.
    InterProiIPR006223. GCS_T.
    IPR028896. GCST/DmdA.
    IPR013977. GCV_T_C.
    IPR006222. GCV_T_N.
    IPR029043. GcvT/YgfZ_C.
    IPR027266. TrmE/GcvT_dom1.
    [Graphical view]
    PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
    PfamiPF01571. GCV_T. 1 hit.
    PF08669. GCV_T_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006487. GcvT. 1 hit.
    SUPFAMiSSF101790. SSF101790. 1 hit.
    TIGRFAMsiTIGR00528. gcvT. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8D2P4-1 [UniParc]FASTAAdd to Basket

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    MSRIPLLEYY IEKGAETGLF GEWEVPYRYT NAIEEHMAVR TSVGLFDVSH    50
    MGRILLKGSD VLPFAQYIYT KDISKTKEHF MSGPMLALNQ WARVKDDEMM 100
    YKVSDEEWLL VTNALARESM LNYFEKVKSE KGFRVEIADL TFNYSMIALQ 150
    GPRAAEVMES LGAKWAGDLK VLEFRMNEEI HGVKTFLVSR SGWTGEDGFE 200
    IWGEHGEMRK LVDLLVSKGV KLAGLIARDT LRIEMGFVLG GHEYGEDPVK 250
    FPCALSLRYG LGAITWEKRG FVGEEALRAC RREGVRWIRV GLKLGKEAGR 300
    LFPRQDAGVY SDDVWVGWVT SGTYSPVLNR GIAMAYVDAR YAVFGEELAV 350
    DIRGKRYPAK IVDFPFIKK 369
    Length:369
    Mass (Da):41,890
    Last modified:March 3, 2009 - v1
    Checksum:i8B69D14FFC7C934C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001140 Genomic DNA. Translation: ACL10625.1.
    RefSeqiYP_002427992.1. NC_011766.1.

    Genome annotation databases

    EnsemblBacteriaiACL10625; ACL10625; DKAM_0299.
    GeneIDi7170573.
    KEGGidka:DKAM_0299.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001140 Genomic DNA. Translation: ACL10625.1 .
    RefSeqi YP_002427992.1. NC_011766.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 490899.DKAM_0299.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL10625 ; ACL10625 ; DKAM_0299 .
    GeneIDi 7170573.
    KEGGi dka:DKAM_0299.

    Phylogenomic databases

    eggNOGi COG0404.
    HOGENOMi HOG000239381.
    KOi K00605.
    OMAi PFFGVQS.

    Enzyme and pathway databases

    BioCyci DKAM490899:GHYH-303-MONOMER.

    Family and domain databases

    Gene3Di 2.40.30.110. 1 hit.
    3.30.1360.120. 2 hits.
    InterProi IPR006223. GCS_T.
    IPR028896. GCST/DmdA.
    IPR013977. GCV_T_C.
    IPR006222. GCV_T_N.
    IPR029043. GcvT/YgfZ_C.
    IPR027266. TrmE/GcvT_dom1.
    [Graphical view ]
    PANTHERi PTHR13847:SF5. PTHR13847:SF5. 1 hit.
    Pfami PF01571. GCV_T. 1 hit.
    PF08669. GCV_T_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006487. GcvT. 1 hit.
    SUPFAMi SSF101790. SSF101790. 1 hit.
    TIGRFAMsi TIGR00528. gcvT. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the anaerobic, protein-degrading hyperthermophilic crenarchaeon Desulfurococcus kamchatkensis."
      Ravin N.V., Mardanov A.V., Beletsky A.V., Kublanov I.V., Kolganova T.V., Lebedinsky A.V., Chernyh N.A., Bonch-Osmolovskaya E.A., Skryabin K.G.
      J. Bacteriol. 191:2371-2379(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1221n / DSM 18924Imported.

    Entry informationi

    Entry nameiB8D2P4_DESK1
    AccessioniPrimary (citable) accession number: B8D2P4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3