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B8D2P4

- B8D2P4_DESK1

UniProt

B8D2P4 - B8D2P4_DESK1

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Protein
Aminomethyltransferase
Gene
DKAM_0299
Organism
Desulfurococcus kamchatkensis (strain 1221n / DSM 18924)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine By similarity.

Catalytic activityi

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.

GO - Molecular functioni

  1. aminomethyltransferase activity Source: UniProtKB-EC
  2. transaminase activity Source: UniProtKB-KW

GO - Biological processi

  1. glycine catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotation, MethyltransferaseImported, Transferase

Enzyme and pathway databases

BioCyciDKAM490899:GHYH-303-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AminomethyltransferaseUniRule annotation (EC:2.1.2.10UniRule annotation)
Gene namesi
Ordered Locus Names:DKAM_0299Imported
OrganismiDesulfurococcus kamchatkensis (strain 1221n / DSM 18924)Imported
Taxonomic identifieri490899 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeDesulfurococcus
ProteomesiUP000006903: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi490899.DKAM_0299.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0404.
HOGENOMiHOG000239381.
KOiK00605.
OMAiPFFGVQS.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
InterProiIPR006223. GCS_T.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamiPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006487. GcvT. 1 hit.
SUPFAMiSSF101790. SSF101790. 1 hit.
TIGRFAMsiTIGR00528. gcvT. 1 hit.

Sequencei

Sequence statusi: Complete.

B8D2P4-1 [UniParc]FASTAAdd to Basket

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MSRIPLLEYY IEKGAETGLF GEWEVPYRYT NAIEEHMAVR TSVGLFDVSH    50
MGRILLKGSD VLPFAQYIYT KDISKTKEHF MSGPMLALNQ WARVKDDEMM 100
YKVSDEEWLL VTNALARESM LNYFEKVKSE KGFRVEIADL TFNYSMIALQ 150
GPRAAEVMES LGAKWAGDLK VLEFRMNEEI HGVKTFLVSR SGWTGEDGFE 200
IWGEHGEMRK LVDLLVSKGV KLAGLIARDT LRIEMGFVLG GHEYGEDPVK 250
FPCALSLRYG LGAITWEKRG FVGEEALRAC RREGVRWIRV GLKLGKEAGR 300
LFPRQDAGVY SDDVWVGWVT SGTYSPVLNR GIAMAYVDAR YAVFGEELAV 350
DIRGKRYPAK IVDFPFIKK 369
Length:369
Mass (Da):41,890
Last modified:March 3, 2009 - v1
Checksum:i8B69D14FFC7C934C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001140 Genomic DNA. Translation: ACL10625.1.
RefSeqiYP_002427992.1. NC_011766.1.

Genome annotation databases

EnsemblBacteriaiACL10625; ACL10625; DKAM_0299.
GeneIDi7170573.
KEGGidka:DKAM_0299.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001140 Genomic DNA. Translation: ACL10625.1 .
RefSeqi YP_002427992.1. NC_011766.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 490899.DKAM_0299.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL10625 ; ACL10625 ; DKAM_0299 .
GeneIDi 7170573.
KEGGi dka:DKAM_0299.

Phylogenomic databases

eggNOGi COG0404.
HOGENOMi HOG000239381.
KOi K00605.
OMAi PFFGVQS.

Enzyme and pathway databases

BioCyci DKAM490899:GHYH-303-MONOMER.

Family and domain databases

Gene3Di 2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
InterProi IPR006223. GCS_T.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view ]
PANTHERi PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfami PF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF006487. GcvT. 1 hit.
SUPFAMi SSF101790. SSF101790. 1 hit.
TIGRFAMsi TIGR00528. gcvT. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the anaerobic, protein-degrading hyperthermophilic crenarchaeon Desulfurococcus kamchatkensis."
    Ravin N.V., Mardanov A.V., Beletsky A.V., Kublanov I.V., Kolganova T.V., Lebedinsky A.V., Chernyh N.A., Bonch-Osmolovskaya E.A., Skryabin K.G.
    J. Bacteriol. 191:2371-2379(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1221n / DSM 18924.

Entry informationi

Entry nameiB8D2P4_DESK1
AccessioniPrimary (citable) accession number: B8D2P4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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