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B8D2L7

- B8D2L7_DESK1

UniProt

B8D2L7 - B8D2L7_DESK1

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Protein

DNA ligase

Gene

lig

Organism
Desulfurococcus kamchatkensis (strain 1221n / DSM 18924)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Note: Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei267 – 2671ATPUniRule annotation
Active sitei269 – 2691N6-AMP-lysine intermediateUniRule annotation
Binding sitei274 – 2741ATPUniRule annotation
Binding sitei289 – 2891ATPUniRule annotation
Binding sitei319 – 3191ATPUniRule annotation
Binding sitei359 – 3591ATPUniRule annotation
Binding sitei436 – 4361ATPUniRule annotation
Binding sitei442 – 4421ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciDKAM490899:GHYH-283-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:DKAM_0279Imported
OrganismiDesulfurococcus kamchatkensis (strain 1221n / DSM 18924)Imported
Taxonomic identifieri490899 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeDesulfurococcus
ProteomesiUP000006903: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi490899.DKAM_0279.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiMVKMLEG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8D2L7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIGQADIPV RLIADVFERI EVITSRIQMT ALLVTLFKQT PPEIIDRVVY
60 70 80 90 100
LIQGRLWPDW KELPELGVGE KLLVKAIALA TNSSEAQVED LAKSLGDLGK
110 120 130 140 150
VAEQLKSRIS GRQQGVTLFS FTQQQPELTV NKVYDTLVRV AMAQGEGSKD
160 170 180 190 200
LKIRLLAGLL REASPKEAKF IVRFAEGRLR VGIGEATVMD ALAITYGGGA
210 220 230 240 250
AARQVIERAY NLRADLGEVA KILALNGLEA LRNVRPEVGV PIRPMLAERL
260 270 280 290 300
SDPKEILEKV GGDAFVEYKY DGERAQIHKK DDKVWIFSRR LENITHQYPD
310 320 330 340 350
VIELARDHLK AREVIVEGEI VAYDLDTGEL KPFQELMHRK RKHEVRTALK
360 370 380 390 400
EYPVKVFLFD LLYADGRDYT IEPLPVRRGK LLEIVDRTDE FTVAEYIRTS
410 420 430 440 450
DVKELEKFFL KAISDGAEGV MVKALHDGSI YQAGTRGWLW IKFKRDYRSE
460 470 480 490 500
MIDTVDLVVV GAFYGKGRRG GKYGALLMAA YNDEKDVFET VCKVGSGFKD
510 520 530 540 550
EDLDKLPEIL KPYIRDRKSP RVVAEMEPDV WVEPALVAEI IGAELTLSPI
560 570 580 590 600
HTCAYGRIKS DAGLSIRFPR FIRWRPDKRP EDATTSNELV EMYNQQLKKI
610
AGESKPVEEA
Length:610
Mass (Da):68,826
Last modified:March 3, 2009 - v1
Checksum:iA1B6FF558E889967
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001140 Genomic DNA. Translation: ACL10605.1.
RefSeqiWP_012607947.1. NC_011766.1.
YP_002427972.1. NC_011766.1.

Genome annotation databases

EnsemblBacteriaiACL10605; ACL10605; DKAM_0279.
GeneIDi7171533.
KEGGidka:DKAM_0279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001140 Genomic DNA. Translation: ACL10605.1 .
RefSeqi WP_012607947.1. NC_011766.1.
YP_002427972.1. NC_011766.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 490899.DKAM_0279.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL10605 ; ACL10605 ; DKAM_0279 .
GeneIDi 7171533.
KEGGi dka:DKAM_0279.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi MVKMLEG.

Enzyme and pathway databases

BioCyci DKAM490899:GHYH-283-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the anaerobic, protein-degrading hyperthermophilic crenarchaeon Desulfurococcus kamchatkensis."
    Ravin N.V., Mardanov A.V., Beletsky A.V., Kublanov I.V., Kolganova T.V., Lebedinsky A.V., Chernyh N.A., Bonch-Osmolovskaya E.A., Skryabin K.G.
    J. Bacteriol. 191:2371-2379(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1221n / DSM 18924Imported.

Entry informationi

Entry nameiB8D2L7_DESK1
AccessioniPrimary (citable) accession number: B8D2L7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: November 26, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3