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B8D2L7

- B8D2L7_DESK1

UniProt

B8D2L7 - B8D2L7_DESK1

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Protein
DNA ligase
Gene
lig, DKAM_0279
Organism
Desulfurococcus kamchatkensis (strain 1221n / DSM 18924)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei267 – 2671ATP By similarityUniRule annotation
Active sitei269 – 2691N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei274 – 2741ATP By similarityUniRule annotation
Binding sitei289 – 2891ATP By similarityUniRule annotation
Binding sitei319 – 3191ATP By similarityUniRule annotation
Binding sitei359 – 3591ATP By similarityUniRule annotation
Binding sitei436 – 4361ATP By similarityUniRule annotation
Binding sitei442 – 4421ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciDKAM490899:GHYH-283-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:DKAM_0279Imported
OrganismiDesulfurococcus kamchatkensis (strain 1221n / DSM 18924)Imported
Taxonomic identifieri490899 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeDesulfurococcus
ProteomesiUP000006903: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi490899.DKAM_0279.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiMVKMLEG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B8D2L7-1 [UniParc]FASTAAdd to Basket

« Hide

MSIGQADIPV RLIADVFERI EVITSRIQMT ALLVTLFKQT PPEIIDRVVY    50
LIQGRLWPDW KELPELGVGE KLLVKAIALA TNSSEAQVED LAKSLGDLGK 100
VAEQLKSRIS GRQQGVTLFS FTQQQPELTV NKVYDTLVRV AMAQGEGSKD 150
LKIRLLAGLL REASPKEAKF IVRFAEGRLR VGIGEATVMD ALAITYGGGA 200
AARQVIERAY NLRADLGEVA KILALNGLEA LRNVRPEVGV PIRPMLAERL 250
SDPKEILEKV GGDAFVEYKY DGERAQIHKK DDKVWIFSRR LENITHQYPD 300
VIELARDHLK AREVIVEGEI VAYDLDTGEL KPFQELMHRK RKHEVRTALK 350
EYPVKVFLFD LLYADGRDYT IEPLPVRRGK LLEIVDRTDE FTVAEYIRTS 400
DVKELEKFFL KAISDGAEGV MVKALHDGSI YQAGTRGWLW IKFKRDYRSE 450
MIDTVDLVVV GAFYGKGRRG GKYGALLMAA YNDEKDVFET VCKVGSGFKD 500
EDLDKLPEIL KPYIRDRKSP RVVAEMEPDV WVEPALVAEI IGAELTLSPI 550
HTCAYGRIKS DAGLSIRFPR FIRWRPDKRP EDATTSNELV EMYNQQLKKI 600
AGESKPVEEA 610
Length:610
Mass (Da):68,826
Last modified:March 3, 2009 - v1
Checksum:iA1B6FF558E889967
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001140 Genomic DNA. Translation: ACL10605.1.
RefSeqiYP_002427972.1. NC_011766.1.

Genome annotation databases

EnsemblBacteriaiACL10605; ACL10605; DKAM_0279.
GeneIDi7171533.
KEGGidka:DKAM_0279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001140 Genomic DNA. Translation: ACL10605.1 .
RefSeqi YP_002427972.1. NC_011766.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 490899.DKAM_0279.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL10605 ; ACL10605 ; DKAM_0279 .
GeneIDi 7171533.
KEGGi dka:DKAM_0279.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi MVKMLEG.

Enzyme and pathway databases

BioCyci DKAM490899:GHYH-283-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the anaerobic, protein-degrading hyperthermophilic crenarchaeon Desulfurococcus kamchatkensis."
    Ravin N.V., Mardanov A.V., Beletsky A.V., Kublanov I.V., Kolganova T.V., Lebedinsky A.V., Chernyh N.A., Bonch-Osmolovskaya E.A., Skryabin K.G.
    J. Bacteriol. 191:2371-2379(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1221n / DSM 18924.

Entry informationi

Entry nameiB8D2L7_DESK1
AccessioniPrimary (citable) accession number: B8D2L7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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