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Protein

DNA ligase

Gene

lig

Organism
Desulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n) (Desulfurococcus kamchatkensis)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei267ATPUniRule annotation1
Active sitei269N6-AMP-lysine intermediateUniRule annotation1
Binding sitei274ATPUniRule annotation1
Binding sitei289ATPUniRule annotation1
Binding sitei319ATPUniRule annotation1
Binding sitei359ATPUniRule annotation1
Binding sitei436ATPUniRule annotation1
Binding sitei442ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:DKAM_0279Imported
OrganismiDesulfurococcus amylolyticus (strain DSM 18924 / JCM 16383 / VKM B-2413 / 1221n) (Desulfurococcus kamchatkensis)Imported
Taxonomic identifieri490899 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiDesulfurococcalesDesulfurococcaceaeDesulfurococcus
Proteomesi
  • UP000006903 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi490899.DKAM_0279.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini347 – 482DNA_LIGASE_A3InterPro annotationAdd BLAST136

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347. Archaea.
COG1793. LUCA.
HOGENOMiHOG000036008.
KOiK10747.
OMAiWLFEESY.
OrthoDBiPOG093Z03L0.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
HAMAPiMF_00407. DNA_ligase. 1 hit.
InterProiView protein in InterPro
IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR036599. DNA_ligase_N_sf.
IPR012340. NA-bd_OB-fold.
PfamiView protein in Pfam
PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiView protein in PROSITE
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.

Sequencei

Sequence statusi: Complete.

B8D2L7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIGQADIPV RLIADVFERI EVITSRIQMT ALLVTLFKQT PPEIIDRVVY
60 70 80 90 100
LIQGRLWPDW KELPELGVGE KLLVKAIALA TNSSEAQVED LAKSLGDLGK
110 120 130 140 150
VAEQLKSRIS GRQQGVTLFS FTQQQPELTV NKVYDTLVRV AMAQGEGSKD
160 170 180 190 200
LKIRLLAGLL REASPKEAKF IVRFAEGRLR VGIGEATVMD ALAITYGGGA
210 220 230 240 250
AARQVIERAY NLRADLGEVA KILALNGLEA LRNVRPEVGV PIRPMLAERL
260 270 280 290 300
SDPKEILEKV GGDAFVEYKY DGERAQIHKK DDKVWIFSRR LENITHQYPD
310 320 330 340 350
VIELARDHLK AREVIVEGEI VAYDLDTGEL KPFQELMHRK RKHEVRTALK
360 370 380 390 400
EYPVKVFLFD LLYADGRDYT IEPLPVRRGK LLEIVDRTDE FTVAEYIRTS
410 420 430 440 450
DVKELEKFFL KAISDGAEGV MVKALHDGSI YQAGTRGWLW IKFKRDYRSE
460 470 480 490 500
MIDTVDLVVV GAFYGKGRRG GKYGALLMAA YNDEKDVFET VCKVGSGFKD
510 520 530 540 550
EDLDKLPEIL KPYIRDRKSP RVVAEMEPDV WVEPALVAEI IGAELTLSPI
560 570 580 590 600
HTCAYGRIKS DAGLSIRFPR FIRWRPDKRP EDATTSNELV EMYNQQLKKI
610
AGESKPVEEA
Length:610
Mass (Da):68,826
Last modified:March 3, 2009 - v1
Checksum:iA1B6FF558E889967
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001140 Genomic DNA. Translation: ACL10605.1.
RefSeqiWP_012607947.1. NC_011766.1.

Genome annotation databases

EnsemblBacteriaiACL10605; ACL10605; DKAM_0279.
GeneIDi7171533.
KEGGidka:DKAM_0279.

Similar proteinsi

Entry informationi

Entry nameiB8D2L7_DESA1
AccessioniPrimary (citable) accession number: B8D2L7
Entry historyiIntegrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: October 25, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported