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B8D1G8

- ARGB_HALOH

UniProt

B8D1G8 - ARGB_HALOH

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Protein

Acetylglutamate kinase

Gene

argB

Organism
Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei29 – 291Transition state stabilizerUniRule annotation
Binding sitei86 – 861SubstrateUniRule annotation
Binding sitei183 – 1831SubstrateUniRule annotation
Sitei246 – 2461Transition state stabilizerUniRule annotation

GO - Molecular functioni

  1. acetylglutamate kinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP
  3. glutamate 5-kinase activity Source: InterPro

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
  2. proline biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHORE373903:GHB1-307-MONOMER.
UniPathwayiUPA00068; UER00107.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylglutamate kinaseUniRule annotation (EC:2.7.2.8UniRule annotation)
Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferaseUniRule annotation
NAG kinaseUniRule annotation
Short name:
AGKUniRule annotation
Gene namesi
Name:argBUniRule annotation
Ordered Locus Names:Hore_02840
OrganismiHalothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
Taxonomic identifieri373903 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalothermothrix
ProteomesiUP000000719: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Acetylglutamate kinasePRO_1000118352Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi373903.Hore_02840.

Structurei

3D structure databases

ProteinModelPortaliB8D1G8.
SMRiB8D1G8. Positions 6-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 652Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the acetylglutamate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0548.
HOGENOMiHOG000233259.
KOiK00930.
OMAiAIHQVNT.
OrthoDBiEOG6T1WVF.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_00082_B. ArgB_B.
InterProiIPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000728. NAGK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00761. argB. 1 hit.

Sequencei

Sequence statusi: Complete.

B8D1G8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEELINKAQT LVEALPYIRN FYGKTFVIKY GGSTMGDKRL KEKIMEDITL
60 70 80 90 100
LKYVGVNPVL IHGGGPAISE AMESMDKEAR FIQGLRITDS ETMSLVEMVL
110 120 130 140 150
VGKVNKELVS IINRLGGEAV GICGKDGGLI EADKLIFEDK SIDLGHVGSV
160 170 180 190 200
KKINPEIVLN LIKGGYIPVI SPVGSSKEGD TYNINADTVA GKLAVSLKAE
210 220 230 240 250
KLIFLTDVDG VWSDPSNEKT RVSSLTVNEV KSWIGEGKIK GGMVPKVEAC
260 270 280 290
IEAVTCGVNR THILNGLIPH ALLLEIFTDR GIGTMILKER
Length:290
Mass (Da):31,411
Last modified:March 3, 2009 - v1
Checksum:iB244D393345CF787
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001098 Genomic DNA. Translation: ACL69045.1.
RefSeqiYP_002508040.1. NC_011899.1.

Genome annotation databases

EnsemblBacteriaiACL69045; ACL69045; Hore_02840.
GeneIDi7314670.
KEGGihor:Hore_02840.
PATRICi22099830. VBIHalOre56292_0302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001098 Genomic DNA. Translation: ACL69045.1 .
RefSeqi YP_002508040.1. NC_011899.1.

3D structure databases

ProteinModelPortali B8D1G8.
SMRi B8D1G8. Positions 6-289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 373903.Hore_02840.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL69045 ; ACL69045 ; Hore_02840 .
GeneIDi 7314670.
KEGGi hor:Hore_02840.
PATRICi 22099830. VBIHalOre56292_0302.

Phylogenomic databases

eggNOGi COG0548.
HOGENOMi HOG000233259.
KOi K00930.
OMAi AIHQVNT.
OrthoDBi EOG6T1WVF.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00107 .
BioCyci HORE373903:GHB1-307-MONOMER.

Family and domain databases

Gene3Di 3.40.1160.10. 1 hit.
HAMAPi MF_00082_B. ArgB_B.
InterProi IPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
[Graphical view ]
Pfami PF00696. AA_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000728. NAGK. 1 hit.
PRINTSi PR00474. GLU5KINASE.
SUPFAMi SSF53633. SSF53633. 1 hit.
TIGRFAMsi TIGR00761. argB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome analysis of the anaerobic thermohalophilic bacterium Halothermothrix orenii."
    Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D., Sun H., Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C.
    PLoS ONE 4:E4192-E4192(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H 168 / OCM 544 / DSM 9562.

Entry informationi

Entry nameiARGB_HALOH
AccessioniPrimary (citable) accession number: B8D1G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: October 29, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3