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Protein

Acetylglutamate kinase

Gene

argB

Organism
Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.UniRule annotation

Catalytic activityi

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Arginine biosynthesis bifunctional protein ArgJ (argJ)
  2. Acetylglutamate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei29Transition state stabilizerUniRule annotation1
Binding sitei86SubstrateUniRule annotation1
Binding sitei183SubstrateUniRule annotation1
Sitei246Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Arginine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHORE373903:GHB1-307-MONOMER.
UniPathwayiUPA00068; UER00107.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylglutamate kinaseUniRule annotation (EC:2.7.2.8UniRule annotation)
Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferaseUniRule annotation
NAG kinaseUniRule annotation
Short name:
NAGKUniRule annotation
Gene namesi
Name:argBUniRule annotation
Ordered Locus Names:Hore_02840
OrganismiHalothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
Taxonomic identifieri373903 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalothermothrix
Proteomesi
  • UP000000719 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001183521 – 290Acetylglutamate kinaseAdd BLAST290

Interactioni

Protein-protein interaction databases

STRINGi373903.Hore_02840.

Structurei

3D structure databases

ProteinModelPortaliB8D1G8.
SMRiB8D1G8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 65Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the acetylglutamate kinase family. ArgB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAS. Bacteria.
COG0548. LUCA.
HOGENOMiHOG000233259.
KOiK00930.
OMAiPKTECCI.
OrthoDBiPOG091H063W.

Family and domain databases

HAMAPiMF_00082. ArgB. 1 hit.
InterProiView protein in InterPro
IPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
PfamiView protein in Pfam
PF00696. AA_kinase. 1 hit.
PIRSFiPIRSF000728. NAGK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00761. argB. 1 hit.

Sequencei

Sequence statusi: Complete.

B8D1G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELINKAQT LVEALPYIRN FYGKTFVIKY GGSTMGDKRL KEKIMEDITL
60 70 80 90 100
LKYVGVNPVL IHGGGPAISE AMESMDKEAR FIQGLRITDS ETMSLVEMVL
110 120 130 140 150
VGKVNKELVS IINRLGGEAV GICGKDGGLI EADKLIFEDK SIDLGHVGSV
160 170 180 190 200
KKINPEIVLN LIKGGYIPVI SPVGSSKEGD TYNINADTVA GKLAVSLKAE
210 220 230 240 250
KLIFLTDVDG VWSDPSNEKT RVSSLTVNEV KSWIGEGKIK GGMVPKVEAC
260 270 280 290
IEAVTCGVNR THILNGLIPH ALLLEIFTDR GIGTMILKER
Length:290
Mass (Da):31,411
Last modified:March 3, 2009 - v1
Checksum:iB244D393345CF787
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001098 Genomic DNA. Translation: ACL69045.1.

Genome annotation databases

EnsemblBacteriaiACL69045; ACL69045; Hore_02840.
KEGGihor:Hore_02840.

Similar proteinsi

Entry informationi

Entry nameiARGB_HALOH
AccessioniPrimary (citable) accession number: B8D1G8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: August 30, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families