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B8D1G8

- ARGB_HALOH

UniProt

B8D1G8 - ARGB_HALOH

Protein

Acetylglutamate kinase

Gene

argB

Organism
Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei29 – 291Transition state stabilizerUniRule annotation
    Binding sitei86 – 861SubstrateUniRule annotation
    Binding sitei183 – 1831SubstrateUniRule annotation
    Sitei246 – 2461Transition state stabilizerUniRule annotation

    GO - Molecular functioni

    1. acetylglutamate kinase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP
    3. glutamate 5-kinase activity Source: InterPro

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP
    2. proline biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHORE373903:GHB1-307-MONOMER.
    UniPathwayiUPA00068; UER00107.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetylglutamate kinaseUniRule annotation (EC:2.7.2.8UniRule annotation)
    Alternative name(s):
    N-acetyl-L-glutamate 5-phosphotransferaseUniRule annotation
    NAG kinaseUniRule annotation
    Short name:
    AGKUniRule annotation
    Gene namesi
    Name:argBUniRule annotation
    Ordered Locus Names:Hore_02840
    OrganismiHalothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
    Taxonomic identifieri373903 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalothermothrix
    ProteomesiUP000000719: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 290290Acetylglutamate kinasePRO_1000118352Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi373903.Hore_02840.

    Structurei

    3D structure databases

    ProteinModelPortaliB8D1G8.
    SMRiB8D1G8. Positions 6-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni64 – 652Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the acetylglutamate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0548.
    HOGENOMiHOG000233259.
    KOiK00930.
    OMAiAIHQVNT.
    OrthoDBiEOG6T1WVF.

    Family and domain databases

    Gene3Di3.40.1160.10. 1 hit.
    HAMAPiMF_00082_B. ArgB_B.
    InterProiIPR004662. AcgluKinase.
    IPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    [Graphical view]
    PfamiPF00696. AA_kinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000728. NAGK. 1 hit.
    PRINTSiPR00474. GLU5KINASE.
    SUPFAMiSSF53633. SSF53633. 1 hit.
    TIGRFAMsiTIGR00761. argB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8D1G8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEELINKAQT LVEALPYIRN FYGKTFVIKY GGSTMGDKRL KEKIMEDITL    50
    LKYVGVNPVL IHGGGPAISE AMESMDKEAR FIQGLRITDS ETMSLVEMVL 100
    VGKVNKELVS IINRLGGEAV GICGKDGGLI EADKLIFEDK SIDLGHVGSV 150
    KKINPEIVLN LIKGGYIPVI SPVGSSKEGD TYNINADTVA GKLAVSLKAE 200
    KLIFLTDVDG VWSDPSNEKT RVSSLTVNEV KSWIGEGKIK GGMVPKVEAC 250
    IEAVTCGVNR THILNGLIPH ALLLEIFTDR GIGTMILKER 290
    Length:290
    Mass (Da):31,411
    Last modified:March 3, 2009 - v1
    Checksum:iB244D393345CF787
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001098 Genomic DNA. Translation: ACL69045.1.
    RefSeqiYP_002508040.1. NC_011899.1.

    Genome annotation databases

    EnsemblBacteriaiACL69045; ACL69045; Hore_02840.
    GeneIDi7314670.
    KEGGihor:Hore_02840.
    PATRICi22099830. VBIHalOre56292_0302.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001098 Genomic DNA. Translation: ACL69045.1 .
    RefSeqi YP_002508040.1. NC_011899.1.

    3D structure databases

    ProteinModelPortali B8D1G8.
    SMRi B8D1G8. Positions 6-289.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 373903.Hore_02840.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL69045 ; ACL69045 ; Hore_02840 .
    GeneIDi 7314670.
    KEGGi hor:Hore_02840.
    PATRICi 22099830. VBIHalOre56292_0302.

    Phylogenomic databases

    eggNOGi COG0548.
    HOGENOMi HOG000233259.
    KOi K00930.
    OMAi AIHQVNT.
    OrthoDBi EOG6T1WVF.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00107 .
    BioCyci HORE373903:GHB1-307-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1160.10. 1 hit.
    HAMAPi MF_00082_B. ArgB_B.
    InterProi IPR004662. AcgluKinase.
    IPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    [Graphical view ]
    Pfami PF00696. AA_kinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000728. NAGK. 1 hit.
    PRINTSi PR00474. GLU5KINASE.
    SUPFAMi SSF53633. SSF53633. 1 hit.
    TIGRFAMsi TIGR00761. argB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome analysis of the anaerobic thermohalophilic bacterium Halothermothrix orenii."
      Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D., Sun H., Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C.
      PLoS ONE 4:E4192-E4192(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: H 168 / OCM 544 / DSM 9562.

    Entry informationi

    Entry nameiARGB_HALOH
    AccessioniPrimary (citable) accession number: B8D1G8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3