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Protein

Acetylglutamate kinase

Gene

argB

Organism
Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.UniRule annotation

Pathway:iL-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Arginine biosynthesis bifunctional protein ArgJ (argJ)
  2. Acetylglutamate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei29 – 291Transition state stabilizerUniRule annotation
Binding sitei86 – 861SubstrateUniRule annotation
Binding sitei183 – 1831SubstrateUniRule annotation
Sitei246 – 2461Transition state stabilizerUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHORE373903:GHB1-307-MONOMER.
UniPathwayiUPA00068; UER00107.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylglutamate kinaseUniRule annotation (EC:2.7.2.8UniRule annotation)
Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferaseUniRule annotation
NAG kinaseUniRule annotation
Short name:
AGKUniRule annotation
Gene namesi
Name:argBUniRule annotation
Ordered Locus Names:Hore_02840
OrganismiHalothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
Taxonomic identifieri373903 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalothermothrix
ProteomesiUP000000719 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Acetylglutamate kinasePRO_1000118352Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi373903.Hore_02840.

Structurei

3D structure databases

ProteinModelPortaliB8D1G8.
SMRiB8D1G8. Positions 6-289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 652Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the acetylglutamate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0548.
HOGENOMiHOG000233259.
KOiK00930.
OMAiPKTECCI.
OrthoDBiEOG6T1WVF.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_00082_B. ArgB_B.
InterProiIPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000728. NAGK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00761. argB. 1 hit.

Sequencei

Sequence statusi: Complete.

B8D1G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELINKAQT LVEALPYIRN FYGKTFVIKY GGSTMGDKRL KEKIMEDITL
60 70 80 90 100
LKYVGVNPVL IHGGGPAISE AMESMDKEAR FIQGLRITDS ETMSLVEMVL
110 120 130 140 150
VGKVNKELVS IINRLGGEAV GICGKDGGLI EADKLIFEDK SIDLGHVGSV
160 170 180 190 200
KKINPEIVLN LIKGGYIPVI SPVGSSKEGD TYNINADTVA GKLAVSLKAE
210 220 230 240 250
KLIFLTDVDG VWSDPSNEKT RVSSLTVNEV KSWIGEGKIK GGMVPKVEAC
260 270 280 290
IEAVTCGVNR THILNGLIPH ALLLEIFTDR GIGTMILKER
Length:290
Mass (Da):31,411
Last modified:March 3, 2009 - v1
Checksum:iB244D393345CF787
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001098 Genomic DNA. Translation: ACL69045.1.

Genome annotation databases

EnsemblBacteriaiACL69045; ACL69045; Hore_02840.
KEGGihor:Hore_02840.
PATRICi22099830. VBIHalOre56292_0302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001098 Genomic DNA. Translation: ACL69045.1.

3D structure databases

ProteinModelPortaliB8D1G8.
SMRiB8D1G8. Positions 6-289.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi373903.Hore_02840.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL69045; ACL69045; Hore_02840.
KEGGihor:Hore_02840.
PATRICi22099830. VBIHalOre56292_0302.

Phylogenomic databases

eggNOGiCOG0548.
HOGENOMiHOG000233259.
KOiK00930.
OMAiPKTECCI.
OrthoDBiEOG6T1WVF.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00107.
BioCyciHORE373903:GHB1-307-MONOMER.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_00082_B. ArgB_B.
InterProiIPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000728. NAGK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00761. argB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome analysis of the anaerobic thermohalophilic bacterium Halothermothrix orenii."
    Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D., Sun H., Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C.
    PLoS ONE 4:E4192-E4192(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H 168 / OCM 544 / DSM 9562.

Entry informationi

Entry nameiARGB_HALOH
AccessioniPrimary (citable) accession number: B8D1G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: July 22, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.