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B8D1G8

- ARGB_HALOH

UniProt

B8D1G8 - ARGB_HALOH

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Protein
Acetylglutamate kinase
Gene
argB, Hore_02840
Organism
Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei29 – 291Transition state stabilizer By similarity
Binding sitei86 – 861Substrate By similarity
Binding sitei183 – 1831Substrate By similarity
Sitei246 – 2461Transition state stabilizer By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. acetylglutamate kinase activity Source: UniProtKB-HAMAP
  3. glutamate 5-kinase activity Source: InterPro

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
  2. proline biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHORE373903:GHB1-307-MONOMER.
UniPathwayiUPA00068; UER00107.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylglutamate kinase (EC:2.7.2.8)
Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name:
AGK
Gene namesi
Name:argB
Ordered Locus Names:Hore_02840
OrganismiHalothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
Taxonomic identifieri373903 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalothermothrix
ProteomesiUP000000719: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Acetylglutamate kinaseUniRule annotation
PRO_1000118352Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi373903.Hore_02840.

Structurei

3D structure databases

ProteinModelPortaliB8D1G8.
SMRiB8D1G8. Positions 6-289.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 652Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0548.
HOGENOMiHOG000233259.
KOiK00930.
OMAiAIHQVNT.
OrthoDBiEOG6T1WVF.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_00082_B. ArgB_B.
InterProiIPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000728. NAGK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR00761. argB. 1 hit.

Sequencei

Sequence statusi: Complete.

B8D1G8-1 [UniParc]FASTAAdd to Basket

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MEELINKAQT LVEALPYIRN FYGKTFVIKY GGSTMGDKRL KEKIMEDITL    50
LKYVGVNPVL IHGGGPAISE AMESMDKEAR FIQGLRITDS ETMSLVEMVL 100
VGKVNKELVS IINRLGGEAV GICGKDGGLI EADKLIFEDK SIDLGHVGSV 150
KKINPEIVLN LIKGGYIPVI SPVGSSKEGD TYNINADTVA GKLAVSLKAE 200
KLIFLTDVDG VWSDPSNEKT RVSSLTVNEV KSWIGEGKIK GGMVPKVEAC 250
IEAVTCGVNR THILNGLIPH ALLLEIFTDR GIGTMILKER 290
Length:290
Mass (Da):31,411
Last modified:March 3, 2009 - v1
Checksum:iB244D393345CF787
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001098 Genomic DNA. Translation: ACL69045.1.
RefSeqiYP_002508040.1. NC_011899.1.

Genome annotation databases

EnsemblBacteriaiACL69045; ACL69045; Hore_02840.
GeneIDi7314670.
KEGGihor:Hore_02840.
PATRICi22099830. VBIHalOre56292_0302.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001098 Genomic DNA. Translation: ACL69045.1 .
RefSeqi YP_002508040.1. NC_011899.1.

3D structure databases

ProteinModelPortali B8D1G8.
SMRi B8D1G8. Positions 6-289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 373903.Hore_02840.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACL69045 ; ACL69045 ; Hore_02840 .
GeneIDi 7314670.
KEGGi hor:Hore_02840.
PATRICi 22099830. VBIHalOre56292_0302.

Phylogenomic databases

eggNOGi COG0548.
HOGENOMi HOG000233259.
KOi K00930.
OMAi AIHQVNT.
OrthoDBi EOG6T1WVF.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00107 .
BioCyci HORE373903:GHB1-307-MONOMER.

Family and domain databases

Gene3Di 3.40.1160.10. 1 hit.
HAMAPi MF_00082_B. ArgB_B.
InterProi IPR004662. AcgluKinase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
[Graphical view ]
Pfami PF00696. AA_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000728. NAGK. 1 hit.
PRINTSi PR00474. GLU5KINASE.
SUPFAMi SSF53633. SSF53633. 1 hit.
TIGRFAMsi TIGR00761. argB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome analysis of the anaerobic thermohalophilic bacterium Halothermothrix orenii."
    Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D., Sun H., Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C.
    PLoS ONE 4:E4192-E4192(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H 168 / OCM 544 / DSM 9562.

Entry informationi

Entry nameiARGB_HALOH
AccessioniPrimary (citable) accession number: B8D1G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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