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B8D1D5

- GCSPA_HALOH

UniProt

B8D1D5 - GCSPA_HALOH

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciHORE373903:GHB1-2418-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:Hore_23420
    OrganismiHalothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
    Taxonomic identifieri373903 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalothermothrix
    ProteomesiUP000000719: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 447447Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000147987Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi373903.Hore_23420.

    Structurei

    3D structure databases

    ProteinModelPortaliB8D1D5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiRLVGQTE.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B8D1D5-1 [UniParc]FASTAAdd to Basket

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    MDYISNTPSE KEAMLKKIGV ENVEDLFKPI PDDVTFKRPF NIPPGLSELE    50
    LKRMIKSKAA RNISMEEQIC FAGGGAYDHY IPAHIDHLIS RSEFYTAYTP 100
    YQAELSQGVL QAMYEYQSMI CELTGMEVAN SSLLDGGSAT GEAVLMASRI 150
    SRKKKILMSR GINPVYREVA RTYGRPRGLE FIDLGLNETV TDMEELEQKL 200
    DEDTGAVVLQ YPNFFGSIED LNVVKNLISA RKRTLLIIVV NPLTLGVLKP 250
    PAEFGADIVV GEGQVLGNPI NYGGPYLGIM ATRKRYVRQM PGRIVGATTD 300
    SDGKRGYVLT LQTREQHIRR ARATSNICTN EALNALTAAI YMATMGKKGI 350
    KEVGEQSFKK AHYMADRIDD MEGFEVVNKD NFFHEFVIKT PLPSAEIGER 400
    LKRKGILGGL DVSRWYSFDG FLVCTTEKRT REEIDGYLEA LEVISSD 447
    Length:447
    Mass (Da):49,916
    Last modified:March 3, 2009 - v1
    Checksum:iBDFFB12BDDFF87C3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001098 Genomic DNA. Translation: ACL71087.1.
    RefSeqiWP_015924055.1. NC_011899.1.
    YP_002510082.1. NC_011899.1.

    Genome annotation databases

    EnsemblBacteriaiACL71087; ACL71087; Hore_23420.
    GeneIDi7314225.
    KEGGihor:Hore_23420.
    PATRICi22104322. VBIHalOre56292_2504.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001098 Genomic DNA. Translation: ACL71087.1 .
    RefSeqi WP_015924055.1. NC_011899.1.
    YP_002510082.1. NC_011899.1.

    3D structure databases

    ProteinModelPortali B8D1D5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 373903.Hore_23420.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL71087 ; ACL71087 ; Hore_23420 .
    GeneIDi 7314225.
    KEGGi hor:Hore_23420.
    PATRICi 22104322. VBIHalOre56292_2504.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi RLVGQTE.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci HORE373903:GHB1-2418-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome analysis of the anaerobic thermohalophilic bacterium Halothermothrix orenii."
      Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D., Sun H., Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C.
      PLoS ONE 4:E4192-E4192(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: H 168 / OCM 544 / DSM 9562.

    Entry informationi

    Entry nameiGCSPA_HALOH
    AccessioniPrimary (citable) accession number: B8D1D5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3