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B8D1D5 (GCSPA_HALOH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Hore_23420
OrganismHalothermothrix orenii (strain H 168 / OCM 544 / DSM 9562) [Complete proteome] [HAMAP]
Taxonomic identifier373903 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalothermothrix

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 447447Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000147987

Sequences

Sequence LengthMass (Da)Tools
B8D1D5 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: BDFFB12BDDFF87C3

FASTA44749,916
        10         20         30         40         50         60 
MDYISNTPSE KEAMLKKIGV ENVEDLFKPI PDDVTFKRPF NIPPGLSELE LKRMIKSKAA 

        70         80         90        100        110        120 
RNISMEEQIC FAGGGAYDHY IPAHIDHLIS RSEFYTAYTP YQAELSQGVL QAMYEYQSMI 

       130        140        150        160        170        180 
CELTGMEVAN SSLLDGGSAT GEAVLMASRI SRKKKILMSR GINPVYREVA RTYGRPRGLE 

       190        200        210        220        230        240 
FIDLGLNETV TDMEELEQKL DEDTGAVVLQ YPNFFGSIED LNVVKNLISA RKRTLLIIVV 

       250        260        270        280        290        300 
NPLTLGVLKP PAEFGADIVV GEGQVLGNPI NYGGPYLGIM ATRKRYVRQM PGRIVGATTD 

       310        320        330        340        350        360 
SDGKRGYVLT LQTREQHIRR ARATSNICTN EALNALTAAI YMATMGKKGI KEVGEQSFKK 

       370        380        390        400        410        420 
AHYMADRIDD MEGFEVVNKD NFFHEFVIKT PLPSAEIGER LKRKGILGGL DVSRWYSFDG 

       430        440 
FLVCTTEKRT REEIDGYLEA LEVISSD 

« Hide

References

[1]"Genome analysis of the anaerobic thermohalophilic bacterium Halothermothrix orenii."
Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D., Sun H., Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C.
PLoS ONE 4:E4192-E4192(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: H 168 / OCM 544 / DSM 9562.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001098 Genomic DNA. Translation: ACL71087.1.
RefSeqYP_002510082.1. NC_011899.1.

3D structure databases

ProteinModelPortalB8D1D5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING373903.Hore_23420.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL71087; ACL71087; Hore_23420.
GeneID7314225.
KEGGhor:Hore_23420.
PATRIC22104322. VBIHalOre56292_2504.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMARLVGQTE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycHORE373903:GHB1-2418-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_HALOH
AccessionPrimary (citable) accession number: B8D1D5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families