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B8D067 (FTHS_HALOH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Hore_00600
OrganismHalothermothrix orenii (strain H 168 / OCM 544 / DSM 9562) [Complete proteome] [HAMAP]
Taxonomic identifier373903 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalothermothrix

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 554554Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000185255

Regions

Nucleotide binding63 – 708ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B8D067 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 2771AA32B81C6321

FASTA55459,069
        10         20         30         40         50         60 
MKSDIEIAQD ARMEPIEEIA EKAGLHKDQI ELYGKYKAKV NTDIIDDDKK DGKLVLVTAI 

        70         80         90        100        110        120 
TPTPAGEGKT TTTVGLGQAL NLLGKKAIIA LREPSLGPTM GIKGGAAGGG YSQVLPMEDI 

       130        140        150        160        170        180 
NLHFTGDIHA IGAAHNLLSA VIDNHIKQGN DLGIDPTSVT WKRVVDMNDR ALRNIVVGLG 

       190        200        210        220        230        240 
GKAHGVPRED GFMITVASEI MAILCLANNL EDLKNKISNI VVGYTYDGEA ITAGDLKVSG 

       250        260        270        280        290        300 
AMTALLKDAI KPNLVQTLEN TPAFIHGGPF ANIAHGCNSI MATKMALKLG EITVTEAGFG 

       310        320        330        340        350        360 
ADLGAEKFFN IKCRYAGLNP DAAVVVATVR ALKMHGGVDK DSLSEENLDA LARGFENLEK 

       370        380        390        400        410        420 
HLENVSKFGV PSVVAINRFP GDTEAELNLV RDKCEEMGVP VAISEVWARG GEGGLDLARK 

       430        440        450        460        470        480 
LVDVLENTPG QFSYLYDVNF PITDKIEKIA KEIYGADGVN YTSKALKQID KYTELGYDKL 

       490        500        510        520        530        540 
PICMAKTQSS ISDDPSLKGR PRGFRINVRE VNLSAGAGFI IPLTGPVLTM PGLPKKPAAE 

       550 
GIDIDADGKI SGLF 

« Hide

References

[1]"Genome analysis of the anaerobic thermohalophilic bacterium Halothermothrix orenii."
Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D., Sun H., Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C.
PLoS ONE 4:E4192-E4192(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: H 168 / OCM 544 / DSM 9562.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001098 Genomic DNA. Translation: ACL68821.1.
RefSeqYP_002507816.1. NC_011899.1.

3D structure databases

ProteinModelPortalB8D067.
SMRB8D067. Positions 4-552.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING373903.Hore_00600.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL68821; ACL68821; Hore_00600.
GeneID7314278.
KEGGhor:Hore_00600.
PATRIC22099348. VBIHalOre56292_0066.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycHORE373903:GHB1-77-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_HALOH
AccessionPrimary (citable) accession number: B8D067
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: April 16, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways