B8CYY3 (B8CYY3_HALOH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lipid-A-disaccharide synthase EMBL ACL70502.1
EC=2.4.1.182 EMBL ACL70502.1

Gene names

Ordered Locus Names:

Hore_17530

Organism

Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562) [Complete proteome] [HAMAP]

Taxonomic identifier

373903 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Halanaerobiales › Halanaerobiaceae › Halothermothrix

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 EMBL ACL70502.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B8CYY3 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: D74BBAE39F2F29D9	FASTA	379	42,902
	10 20 30 40 50 60 MGKIMVVAGE VSGDMHAARV VREIKKLAPE TRFFGMGSKC LREAGVEVLV DPTDISTIGF 70 80 90 100 110 120 SEALKNYRQH RDHLKMMKKA LEREKPDVAL LVDYSGFNIK MARITKRKKI PTVSYFSPSA 130 140 150 160 170 180 WVWGKRRARK MARARAVIAS VFPMEEKVYR EAGAEVHFVG HPLLDMVNVE ESKDEICRKL 190 200 210 220 230 240 ELDGEKPIIG LMPGSRKQEV EYLLPEMLKA AERLKKEKGD FQFVIPVAPG IDRDKIVEMA 250 260 270 280 290 300 SRYKLVLKVV EGANYEVMKA SDFLVVASGT ATLEATIIGT PMVIVYRTSW STYHLGKLLV 310 320 330 340 350 360 NLDYIGLPNI IADREIVPEL LQQDVTADNI YREITNFMSK PYLIKSIKRD LEYVKNKLGR 370 PGAVRRTAEL VLKKGKLYI

References

[1]

"Genome analysis of the anaerobic thermohalophilic bacterium Halothermothrix orenii." Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D., Sun H., Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C. PLoS ONE 4:E4192-E4192(2009) [PubMed: 19145256] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001098 Genomic DNA. Translation: ACL70502.1.
RefSeq	YP_002509497.1. NC_011899.1.
3D structure databases
ProteinModelPortal	B8CYY3.
ModBase	Search...
Protein-protein interaction databases
STRING	B8CYY3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7313675.
GenomeReviews	Gene locus Hore_17530 in contig CP001098_GR.
KEGG	hor:Hore_17530.
PATRIC	22103032. VBIHalOre56292_1867.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG584837.
OMA	PDFNLGL.
ProtClustDB	CLSK2806530.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B8CYY3_HALOH

Accession

Primary (citable) accession number: B8CYY3

Entry history

Integrated into UniProtKB/TrEMBL:	March 3, 2009
Last sequence update:	March 3, 2009
Last modified:	December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)