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B8CXR8

- SYL_HALOH

UniProt

B8CXR8 - SYL_HALOH

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei588 – 5881ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHORE373903:GHB1-1389-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Hore_13370
    OrganismiHalothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
    Taxonomic identifieri373903 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalothermothrix
    ProteomesiUP000000719: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 830830Leucine--tRNA ligasePRO_1000199209Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi373903.Hore_13370.

    Structurei

    3D structure databases

    ProteinModelPortaliB8CXR8.
    SMRiB8CXR8. Positions 1-766.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi585 – 5895"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiDKPKYYA.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8CXR8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGYYNFADI EKKWQDKWEK DGLYKTQEET DKDNYYVLEM FPYPSGNLHM    50
    GHVRVYSIGD VIARFKRMNG YNVLHPMGWD AFGLPAENAA IKHGNIHPQD 100
    WTWDNIKNMK KQMKSLGLSY DWDREVTTAK EDYYKWTQWF FVKMFKKGLA 150
    YKKKAAVNWC PGCETVLANE QVVNNACERC GTEVEEKELE QWFFKITNYA 200
    ERLLEDHKLL QNWPEKVKIM QRNWIGRSEG MRIKFPVKGS SEEIEVFTTR 250
    PDTIFGATYM VLAPEHPLVE KLISGTEKEK EVRQFIDRVK KQKEMERTSP 300
    ESEKEGLFTG AYAINPMTGE EIPIMIANYV LMGYGTGAIM AVPAHDQRDF 350
    DFARKYDLPI RVVIQPEERE EELKDTDLNE AYEGSGHLIN SDKYNGLTVK 400
    EAFDVMAEDM EKEGIGKREV NYRLRDWLIS RQRYWGTPIP IVYCEKCGTV 450
    PVPEEELPVV LPRDVEFSPT GESPLAKVDE FVNTTCPVCG GKARRETDTM 500
    DTFVDSSWYF LRYTDPKNDK LPFSKENAKK WFPVDQYIGG IEHAILHLLY 550
    ARFFTKVIYD MDMIDSVEPF TNWLAQGMVL KDGAKMSKSK GNVVDPEDIL 600
    DRFGADTARL FILFAAPPEK DLEWSDRGVE GAERFLNRVW RLVADNIKEI 650
    KNTDQASLDV NSFNKNEKDL YRNLHVTIKR VTEDIGERLN FNTAISAIME 700
    LTNATYQYLN GVEKVNYTLI KDIIEKMLLI LAPFAPHMTE ELWSELGNDE 750
    SIHIQKWPGY EEKALKKDEV TIVVQVNGKV RDKLQVSADI DEDKLKEQVL 800
    ELPRIQKYTE GKEIVKTIII PKKLVNIVVK 830
    Length:830
    Mass (Da):96,269
    Last modified:March 3, 2009 - v1
    Checksum:i9BB05557D27E2CE8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001098 Genomic DNA. Translation: ACL70087.1.
    RefSeqiYP_002509082.1. NC_011899.1.

    Genome annotation databases

    EnsemblBacteriaiACL70087; ACL70087; Hore_13370.
    GeneIDi7314123.
    KEGGihor:Hore_13370.
    PATRICi22102120. VBIHalOre56292_1419.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001098 Genomic DNA. Translation: ACL70087.1 .
    RefSeqi YP_002509082.1. NC_011899.1.

    3D structure databases

    ProteinModelPortali B8CXR8.
    SMRi B8CXR8. Positions 1-766.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 373903.Hore_13370.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL70087 ; ACL70087 ; Hore_13370 .
    GeneIDi 7314123.
    KEGGi hor:Hore_13370.
    PATRICi 22102120. VBIHalOre56292_1419.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi DKPKYYA.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci HORE373903:GHB1-1389-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome analysis of the anaerobic thermohalophilic bacterium Halothermothrix orenii."
      Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D., Sun H., Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C.
      PLoS ONE 4:E4192-E4192(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: H 168 / OCM 544 / DSM 9562.

    Entry informationi

    Entry nameiSYL_HALOH
    AccessioniPrimary (citable) accession number: B8CXR8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3