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B8CXG4 (RUVC_HALOH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Crossover junction endodeoxyribonuclease RuvC

EC=3.1.22.4
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene names
Name:ruvC
Ordered Locus Names:Hore_12330
OrganismHalothermothrix orenii (strain H 168 / OCM 544 / DSM 9562) [Complete proteome] [HAMAP]
Taxonomic identifier373903 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalothermothrix

Protein attributes

Sequence length165 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity. HAMAP-Rule MF_00034

Catalytic activity

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). HAMAP-Rule MF_00034

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00034

Sequence similarities

Belongs to the RuvC family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 165165Crossover junction endodeoxyribonuclease RuvC HAMAP-Rule MF_00034
PRO_1000195261

Sites

Metal binding71Magnesium By similarity
Metal binding671Magnesium By similarity
Metal binding1401Magnesium By similarity
Metal binding1431Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
B8CXG4 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 4880721A03C7ABE3

FASTA16518,307
        10         20         30         40         50         60 
MVILGVDPGL AIVGYALIEK QGNKYRVIDY GSINTPSKLE SVDRLKIIHT DMVNIINKYN 

        70         80         90        100        110        120 
PDQMAVEKLF FNKNVKTAIE VGQARGVILL AGSQARLKIY EYTPLQVKQA VAGYGRAHKS 

       130        140        150        160 
QVQRMVKALL NLNEIPKPDD VADALAISIC HGNSYRLNRK WGTKG 

« Hide

References

[1]"Genome analysis of the anaerobic thermohalophilic bacterium Halothermothrix orenii."
Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D., Sun H., Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C.
PLoS ONE 4:E4192-E4192(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: H 168 / OCM 544 / DSM 9562.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001098 Genomic DNA. Translation: ACL69983.1.
RefSeqYP_002508978.1. NC_011899.1.

3D structure databases

ProteinModelPortalB8CXG4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING373903.Hore_12330.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL69983; ACL69983; Hore_12330.
GeneID7313934.
KEGGhor:Hore_12330.
PATRIC22101900. VBIHalOre56292_1310.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0817.
HOGENOMHOG000012182.
KOK01159.
OMANKNARTA.
OrthoDBEOG6RG044.

Enzyme and pathway databases

BioCycHORE373903:GHB1-1283-MONOMER.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
HAMAPMF_00034. RuvC.
InterProIPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSPR00696. RSOLVASERUVC.
SUPFAMSSF53098. SSF53098. 1 hit.
TIGRFAMsTIGR00228. ruvC. 1 hit.
PROSITEPS01321. RUVC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRUVC_HALOH
AccessionPrimary (citable) accession number: B8CXG4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families