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B8CWG2 (UPPP_HALOH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Hore_08750
OrganismHalothermothrix orenii (strain H 168 / OCM 544 / DSM 9562) [Complete proteome] [HAMAP]
Taxonomic identifier373903 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalothermothrix

Protein attributes

Sequence length259 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 259259Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000148816

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane40 – 6021Helical; Potential
Transmembrane75 – 9521Helical; Potential
Transmembrane101 – 12121Helical; Potential
Transmembrane179 – 19921Helical; Potential
Transmembrane206 – 22621Helical; Potential
Transmembrane239 – 25921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B8CWG2 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 99088AE5C50CD683

FASTA25928,837
        10         20         30         40         50         60 
MEIFKVIFLG IIQGLTEFLP ISSSGHLVLF QELLGINTDQ ITLDVFLHFG TVIPVLIIFW 

        70         80         90        100        110        120 
DDVRDIIFFK KEKRWLTILI LVGIIPTGII GILFEDFFAN LFSSVKTVGF MLLVTGFLLY 

       130        140        150        160        170        180 
LSEKLSNYNK ELKEMQYHNA LIVGVAQGMA IIPGISRSGS TIVASLLQGF DRDAAARYSF 

       190        200        210        220        230        240 
LLSAPVIFGA GLVELKDALS TGLEQLTWLS IIIGTIFAAL SGYFAIKYLL YILRKGKLTV 

       250 
FAYYCWIVGI MIIILAGIF 

« Hide

References

[1]"Genome analysis of the anaerobic thermohalophilic bacterium Halothermothrix orenii."
Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D., Sun H., Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C.
PLoS ONE 4:E4192-E4192(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: H 168 / OCM 544 / DSM 9562.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001098 Genomic DNA. Translation: ACL69631.1.
RefSeqYP_002508626.1. NC_011899.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING373903.Hore_08750.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACL69631; ACL69631; Hore_08750.
GeneID7314862.
KEGGhor:Hore_08750.
PATRIC22101110. VBIHalOre56292_0930.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAWEFLATG.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycHORE373903:GHB1-911-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_HALOH
AccessionPrimary (citable) accession number: B8CWG2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families