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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciHORE373903:GHB1-911-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Hore_08750
OrganismiHalothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
Taxonomic identifieri373903 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalothermothrix
Proteomesi
  • UP000000719 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21
Transmembranei40 – 60HelicalUniRule annotationAdd BLAST21
Transmembranei75 – 95HelicalUniRule annotationAdd BLAST21
Transmembranei101 – 121HelicalUniRule annotationAdd BLAST21
Transmembranei179 – 199HelicalUniRule annotationAdd BLAST21
Transmembranei206 – 226HelicalUniRule annotationAdd BLAST21
Transmembranei239 – 259HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001488161 – 259Undecaprenyl-diphosphataseAdd BLAST259

Interactioni

Protein-protein interaction databases

STRINGi373903.Hore_08750.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
HOGENOMiHOG000218357.
KOiK06153.
OMAiRNDDAHM.
OrthoDBiPOG091H00ZR.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

B8CWG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIFKVIFLG IIQGLTEFLP ISSSGHLVLF QELLGINTDQ ITLDVFLHFG
60 70 80 90 100
TVIPVLIIFW DDVRDIIFFK KEKRWLTILI LVGIIPTGII GILFEDFFAN
110 120 130 140 150
LFSSVKTVGF MLLVTGFLLY LSEKLSNYNK ELKEMQYHNA LIVGVAQGMA
160 170 180 190 200
IIPGISRSGS TIVASLLQGF DRDAAARYSF LLSAPVIFGA GLVELKDALS
210 220 230 240 250
TGLEQLTWLS IIIGTIFAAL SGYFAIKYLL YILRKGKLTV FAYYCWIVGI

MIIILAGIF
Length:259
Mass (Da):28,837
Last modified:March 3, 2009 - v1
Checksum:i99088AE5C50CD683
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001098 Genomic DNA. Translation: ACL69631.1.
RefSeqiWP_012635818.1. NC_011899.1.

Genome annotation databases

EnsemblBacteriaiACL69631; ACL69631; Hore_08750.
KEGGihor:Hore_08750.
PATRICi22101110. VBIHalOre56292_0930.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001098 Genomic DNA. Translation: ACL69631.1.
RefSeqiWP_012635818.1. NC_011899.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi373903.Hore_08750.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACL69631; ACL69631; Hore_08750.
KEGGihor:Hore_08750.
PATRICi22101110. VBIHalOre56292_0930.

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
HOGENOMiHOG000218357.
KOiK06153.
OMAiRNDDAHM.
OrthoDBiPOG091H00ZR.

Enzyme and pathway databases

BioCyciHORE373903:GHB1-911-MONOMER.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUPPP_HALOH
AccessioniPrimary (citable) accession number: B8CWG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: September 7, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.