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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi492MagnesiumUniRule annotation1
Metal bindingi498MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Hore_07900
OrganismiHalothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
Taxonomic identifieri373903 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalothermothrix
Proteomesi
  • UP000000719 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001857391 – 705Polyribonucleotide nucleotidyltransferaseAdd BLAST705

Proteomic databases

PRIDEiB8CW78

Interactioni

Protein-protein interaction databases

STRINGi373903.Hore_07900

Structurei

3D structure databases

ProteinModelPortaliB8CW78
SMRiB8CW78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini559 – 618KHUniRule annotationAdd BLAST60
Domaini628 – 696S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218327
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

B8CW78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKDWTIDVA GGKMKFETGK YAKQANGSVV ARYGDTTVLV TATMSEPREG
60 70 80 90 100
IDYFPLMVNY EERVYAIGKI PGSITRREGR PRDVATLAAR LIDRPLRPLF
110 120 130 140 150
PEGFRHDVQI IATVLSVDND CEPDILALNG ASVALTLSDI PFDGPIGGVK
160 170 180 190 200
VGLVDGELVI NPDEEEREKS KLDLTVAGTR DAVLMVEAGA NEVSEDVMLD
210 220 230 240 250
AIELAHQEIK RLVLLQEEIG EEAGKKKFEF TKDEITPELD EEIRKYISSD
260 270 280 290 300
MENALRIPEK LERNAKVDEI KENTLQYFED MFENNGLDNE EKNKQLKMVE
310 320 330 340 350
RTIEKVMKEK VRKMIIEEGI RPDGRKPDEI RPIWCEVGTL PRVHGSGVFT
360 370 380 390 400
RGQTQALSVV TLGATSDEQI LFGLGEEETK RYMHHYNFPP YSVGETSPLR
410 420 430 440 450
SPGRREIGHG ALGERALQPV IPDQEEFPYT IRVVSEVLES NGSTSQASIC
460 470 480 490 500
GSTLALMDAG VPIKEPVAGI AMGLLKEDEK VVILSDIQGL EDFYGDMDFK
510 520 530 540 550
VAGTRNGITA LQMDIKIHGI SKEILKKALK RAREGRLYIL DKMLQVIDKP
560 570 580 590 600
RPELSPYAPL MITMKVSPDK IRHIIGPGGK IINKIIDETG VEIDIDDDGS
610 620 630 640 650
VYILAQDQES GNRAKEIINK LTKEVEVGDI YEGRVKKITN FGAFVEILPG
660 670 680 690 700
REGLVHISEL ADHHVKKVED IVKIGDRIPV KVIEIDELGR INLSRKRALK

EQKKE
Length:705
Mass (Da):78,672
Last modified:March 3, 2009 - v1
Checksum:i481278DC741A53AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001098 Genomic DNA Translation: ACL69547.1
RefSeqiWP_012635735.1, NC_011899.1

Genome annotation databases

EnsemblBacteriaiACL69547; ACL69547; Hore_07900
KEGGihor:Hore_07900

Similar proteinsi

Entry informationi

Entry nameiPNP_HALOH
AccessioniPrimary (citable) accession number: B8CW78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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