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B8CW78

- PNP_HALOH

UniProt

B8CW78 - PNP_HALOH

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi492 – 4921MagnesiumUniRule annotation
    Metal bindingi498 – 4981MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciHORE373903:GHB1-826-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:Hore_07900
    OrganismiHalothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)
    Taxonomic identifieri373903 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalanaerobiaceaeHalothermothrix
    ProteomesiUP000000719: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 705705Polyribonucleotide nucleotidyltransferasePRO_1000185739Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi373903.Hore_07900.

    Structurei

    3D structure databases

    ProteinModelPortaliB8CW78.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini559 – 61860KHUniRule annotationAdd
    BLAST
    Domaini628 – 69669S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218327.
    KOiK00962.
    OMAiISMEDTH.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B8CW78-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHKDWTIDVA GGKMKFETGK YAKQANGSVV ARYGDTTVLV TATMSEPREG    50
    IDYFPLMVNY EERVYAIGKI PGSITRREGR PRDVATLAAR LIDRPLRPLF 100
    PEGFRHDVQI IATVLSVDND CEPDILALNG ASVALTLSDI PFDGPIGGVK 150
    VGLVDGELVI NPDEEEREKS KLDLTVAGTR DAVLMVEAGA NEVSEDVMLD 200
    AIELAHQEIK RLVLLQEEIG EEAGKKKFEF TKDEITPELD EEIRKYISSD 250
    MENALRIPEK LERNAKVDEI KENTLQYFED MFENNGLDNE EKNKQLKMVE 300
    RTIEKVMKEK VRKMIIEEGI RPDGRKPDEI RPIWCEVGTL PRVHGSGVFT 350
    RGQTQALSVV TLGATSDEQI LFGLGEEETK RYMHHYNFPP YSVGETSPLR 400
    SPGRREIGHG ALGERALQPV IPDQEEFPYT IRVVSEVLES NGSTSQASIC 450
    GSTLALMDAG VPIKEPVAGI AMGLLKEDEK VVILSDIQGL EDFYGDMDFK 500
    VAGTRNGITA LQMDIKIHGI SKEILKKALK RAREGRLYIL DKMLQVIDKP 550
    RPELSPYAPL MITMKVSPDK IRHIIGPGGK IINKIIDETG VEIDIDDDGS 600
    VYILAQDQES GNRAKEIINK LTKEVEVGDI YEGRVKKITN FGAFVEILPG 650
    REGLVHISEL ADHHVKKVED IVKIGDRIPV KVIEIDELGR INLSRKRALK 700
    EQKKE 705
    Length:705
    Mass (Da):78,672
    Last modified:March 3, 2009 - v1
    Checksum:i481278DC741A53AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001098 Genomic DNA. Translation: ACL69547.1.
    RefSeqiYP_002508542.1. NC_011899.1.

    Genome annotation databases

    EnsemblBacteriaiACL69547; ACL69547; Hore_07900.
    GeneIDi7314777.
    KEGGihor:Hore_07900.
    PATRICi22100932. VBIHalOre56292_0841.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001098 Genomic DNA. Translation: ACL69547.1 .
    RefSeqi YP_002508542.1. NC_011899.1.

    3D structure databases

    ProteinModelPortali B8CW78.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 373903.Hore_07900.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACL69547 ; ACL69547 ; Hore_07900 .
    GeneIDi 7314777.
    KEGGi hor:Hore_07900.
    PATRICi 22100932. VBIHalOre56292_0841.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218327.
    KOi K00962.
    OMAi ISMEDTH.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci HORE373903:GHB1-826-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome analysis of the anaerobic thermohalophilic bacterium Halothermothrix orenii."
      Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D., Sun H., Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C.
      PLoS ONE 4:E4192-E4192(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: H 168 / OCM 544 / DSM 9562.

    Entry informationi

    Entry nameiPNP_HALOH
    AccessioniPrimary (citable) accession number: B8CW78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3