B8CW13 (SMC_HALOH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosome partition protein Smc

Gene names

Name:	smc
Ordered Locus Names:	Hore_07250

Organism

Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562) [Complete proteome] [HAMAP]

Taxonomic identifier

373903 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Halanaerobiales › Halanaerobiaceae › Halothermothrix › Halothermothrix orenii

Protein attributes

Sequence length	1185 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for chromosome condensation and partitioning By similarity. HAMAP-Rule MF_01894
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Domain	Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures By similarity. HAMAP-Rule MF_01894
Sequence similarities	Belongs to the SMC family.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Coiled coil
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA recombination Inferred from electronic annotation. Source: InterPro DNA repair Inferred from electronic annotation. Source: InterPro DNA replication Inferred from electronic annotation. Source: HAMAP chromosome condensation Inferred from electronic annotation. Source: InterPro sister chromatid cohesion Inferred from electronic annotation. Source: InterPro
Cellular_component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1185	1185	Chromosome partition protein Smc HAMAP-Rule MF_01894		PRO_0000409274
Regions
	Nucleotide binding	32 – 39	8	ATP By similarity
	Coiled coil	167 – 494	328	Potential
	Coiled coil	677 – 1031	355	Potential

Sequences

	Sequence		Length	Mass (Da)
	B8CW13 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: 7C49A7170E1FB6AB	FASTA	1,185	137,294
	10 20 30 40 50 60 MFLKKLELKG FKSFAKPITI NFESPITAIV GPNGSGKSNI VDAIRWVLGE QSAKTLRGSR 70 80 90 100 110 120 MADVIFAGSK DYKALNKASV TLYLDNQDKI LPLDVSTVKI SRKVNMDGQS DYYLNGKICR 130 140 150 160 170 180 LKDIENLLMD TGLGKDTYSI VGQGKIDSII NSRPEKLREL FEEAAGISKY KSRKMDAEKR 190 200 210 220 230 240 LEKTNHDLQR IEDLIWELEK QVGPLEKAAQ KAKKYRRLKE ELKVLEVNLL LDKWDKNLDR 250 260 270 280 290 300 LSSFEEDEQL LIHKLKSLTN NLTESQEKLE SLQRTLKVKK DELSRLRDRY YRQKSKREEA 310 320 330 340 350 360 ENTLCILEER RQGLSREKEN LNQEIKDLNL RREELTGRLD EIGSRLIELK EKIDNYNQNY 370 380 390 400 410 420 ESKKVLLDEI KENLDREKQD LFFLRNNILD GNVELKDISS QFEQLKERGR HLEEEIKRIK 430 440 450 460 470 480 TTRDKISSEY DALNEREDKL RTYLKSVDNK IEEKRSVLTD LKEEELNLQA RLEEAKKRFN 490 500 510 520 530 540 RTRNKLNEKN SHLSILHEME DSLEGYYRGV KNILKARSKL TGIIGVVADQ IEVDKKYELA 550 560 570 580 590 600 IETALGGRLQ NIIVKDDKSA RECVDYLKET KGGQATFLPV NMVNGRKVNF KNNQVKKVDG 610 620 630 640 650 660 FLGIASSFVD CEDYLKPVIE YLLGRTIIST DLKSAIEIAR LRKRGFKIVT LEGDVINSGG 670 680 690 700 710 720 AITGGSKNSN KKMLLSRSRK IEDLKKEVLK LQNSLGEDSK NLNQLENKLK EVLNKKEVIK 730 740 750 760 770 780 NDIRDLEIEK NNYHKDLIRL EQEKTKLSER LEEIDEEFVD CHDRLGKNDA AKQKLEDKLK 790 800 810 820 830 840 ALNDDFSLEK NEIENKEKRV EELEARHENI NDEITRLKIN LAQLNEKRES LRKEEEKSNK 850 860 870 880 890 900 ELIELAEKNE EFKERYNKIL SEIKGINNKE GQLNELKVKL SGEIEKLKND LNLTEKEVEE 910 920 930 940 950 960 KQQRIDMLQR EVSDLQTRLD KKKDEKHQIE LKITRLENRN ERIVEILEND YDVKPEDGFD 970 980 990 1000 1010 1020 DRIKITNYSR AGQKVKELKN AIKKLGTVNQ GAIEEYNDLV DRLDYLQNQH DDLLKAKESI 1030 1040 1050 1060 1070 1080 TKVIQEIEET MSSLFHEAFL KVNGEFNNTF KELFNGGQAS LKLTEPENLL ETGVEIVAQP 1090 1100 1110 1120 1130 1140 PGKQLKKLSL MSGGERALTA IALVFAFLKV NPSPFYILDE IDAPLDDANV TRFARYIKEY 1150 1160 1170 1180 SRFAQFLIVT HRKNMMAEAE TIYGVTMEES GVSKLISLKL SEQII

References

[1]

"Genome analysis of the anaerobic thermohalophilic bacterium Halothermothrix orenii." Mavromatis K., Ivanova N., Anderson I., Lykidis A., Hooper S.D., Sun H., Kunin V., Lapidus A., Hugenholtz P., Patel B., Kyrpides N.C. PLoS ONE 4:E4192-E4192(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: H 168 / OCM 544 / DSM 9562.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001098 Genomic DNA. Translation: ACL69482.1.
RefSeq	YP_002508477.1. NC_011899.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	373903.Hore_07250.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACL69482; ACL69482; Hore_07250.
GeneID	7312960.
KEGG	hor:Hore_07250.
PATRIC	22100802. VBIHalOre56292_0776.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1196.
HOGENOM	HOG000036392.
KO	K03529.
OMA	WARISKL.
Enzyme and pathway databases
BioCyc	HORE373903:GHB1-761-MONOMER.
Family and domain databases
HAMAP	MF_01894. Smc_prok.
InterPro	IPR003395. RecF/RecN/SMC. IPR024704. SMC. IPR010935. SMC_hinge. IPR011890. SMC_prok. [Graphical view]
Pfam	PF06470. SMC_hinge. 1 hit. PF02463. SMC_N. 1 hit. [Graphical view]
PIRSF	PIRSF005719. SMC. 1 hit.
SMART	SM00968. SMC_hinge. 1 hit. [Graphical view]
SUPFAM	SSF75553. SMC_hinge. 1 hit.
TIGRFAMs	TIGR02168. SMC_prok_B. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SMC_HALOH

Accession

Primary (citable) accession number: B8CW13

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 31, 2011
Last sequence update:	March 3, 2009
Last modified:	May 1, 2013
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program