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B8CTW4

- PUR9_SHEPW

UniProt

B8CTW4 - PUR9_SHEPW

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, swp_4724
Organism
Shewanella piezotolerans (strain WP3 / JCM 13877)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciSPIE225849:GH6V-4579-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:swp_4724
OrganismiShewanella piezotolerans (strain WP3 / JCM 13877)
Taxonomic identifieri225849 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000000753: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000192980Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi225849.swp_4724.

Structurei

3D structure databases

ProteinModelPortaliB8CTW4.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B8CTW4-1 [UniParc]FASTAAdd to Basket

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MNNARPIRRA LLSVSDKTGI LEFAQALHAQ GVELLSTGGT ARLLADNGVP    50
VIEVSDYTGH PEIMDGRVKT LHPKVHGGIL ARRGIDELVM EQNNINPIDL 100
VAVNLYPFAE TVAKEGCTLA DAVENIDIGG PTMVRSTAKN HKDTTIIVNA 150
SDYGRVIAEM QANEGSTTLE TRFDLAIAAF EHTAAYDGMI ANYFGTKVPA 200
HSKDECHEDS KFPRTYNTQL VKKQDLRYGE NSHQTAAFYV DTNLDEASVA 250
TAVQLQGKAL SYNNIADTDS ALECVKEFDE PACVIVKHAN PCGVAIGDNL 300
LEAYNRAFQT DPTSAFGGII AFNGELDAAT AAAIVERQFV EVIIAPSVSQ 350
AARDVVAAKA NVRLLECGQW ASKTTSLDYK RVNGGLLLQD RDQGMVGIDD 400
VKVVSKRQPT ASEMKDLMFC WKVAKFVKSN AIVYAKNSMT IGVGAGQMSR 450
VYSAKVAGIK AADEGLVVQD SVMASDAFFP FRDGIDAAAE AGISCIIQPG 500
GSIRDEEIIN AADEHGMAMV FTGMRHFRH 529
Length:529
Mass (Da):56,980
Last modified:March 3, 2009 - v1
Checksum:i2CF9A088E9535216
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000472 Genomic DNA. Translation: ACJ31358.1.
RefSeqiYP_002313945.1. NC_011566.1.

Genome annotation databases

EnsemblBacteriaiACJ31358; ACJ31358; swp_4724.
GeneIDi7035642.
KEGGiswp:swp_4724.
PATRICi23547707. VBIShePie65056_4349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000472 Genomic DNA. Translation: ACJ31358.1 .
RefSeqi YP_002313945.1. NC_011566.1.

3D structure databases

ProteinModelPortali B8CTW4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 225849.swp_4724.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ31358 ; ACJ31358 ; swp_4724 .
GeneIDi 7035642.
KEGGi swp:swp_4724.
PATRICi 23547707. VBIShePie65056_4349.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci SPIE225849:GH6V-4579-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3."
    Wang F., Wang J., Jian H., Zhang B., Li S., Wang F., Zeng X., Gao L., Bartlett D.H., Yu J., Hu S., Xiao X.
    PLoS ONE 3:E1937-E1937(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WP3 / JCM 13877.

Entry informationi

Entry nameiPUR9_SHEPW
AccessioniPrimary (citable) accession number: B8CTW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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