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Protein

Enoyl-[acyl-carrier-protein] reductase [NADH]

Gene

fabV

Organism
Shewanella piezotolerans (strain WP3 / JCM 13877)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).UniRule annotation

Catalytic activityi

An acyl-[acyl-carrier protein] + NAD+ = a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH.UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei75Plays an important role in discriminating NADH against NADPHUniRule annotation1
Binding sitei225SubstrateUniRule annotation1
Active sitei235Proton donorUniRule annotation1
Binding sitei244NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi48 – 53NADUniRule annotation6
Nucleotide bindingi74 – 75NADUniRule annotation2
Nucleotide bindingi111 – 112NADUniRule annotation2
Nucleotide bindingi139 – 140NADUniRule annotation2
Nucleotide bindingi273 – 275NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandNAD

Enzyme and pathway databases

BioCyciSPIE225849:G1G7F-2962-MONOMER
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
Enoyl-[acyl-carrier-protein] reductase [NADH]UniRule annotation (EC:1.3.1.9UniRule annotation)
Short name:
ENRUniRule annotation
Gene namesi
Name:fabVUniRule annotation
Ordered Locus Names:swp_3256
OrganismiShewanella piezotolerans (strain WP3 / JCM 13877)
Taxonomic identifieri225849 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000000753 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001883691 – 400Enoyl-[acyl-carrier-protein] reductase [NADH]Add BLAST400

Proteomic databases

PRIDEiB8CRF2

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi225849.swp_3256

Structurei

3D structure databases

SMRiB8CRF2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TER reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105RKW Bacteria
COG3007 LUCA
HOGENOMiHOG000269390
KOiK00209
OMAiEGCIEQI
OrthoDBiPOG091H03HI

Family and domain databases

HAMAPiMF_01838 FabV_reductase, 1 hit
InterProiView protein in InterPro
IPR024906 Eno_Rdtase_FAD-bd_dom
IPR024910 Enoyl-CoA_Rdtase_cat_dom
IPR010758 Trans-2-enoyl-CoA_reductase
PANTHERiPTHR37480 PTHR37480, 1 hit
PfamiView protein in Pfam
PF07055 Eno-Rase_FAD_bd, 1 hit
PF12242 Eno-Rase_NADH_b, 1 hit
PF12241 Enoyl_reductase, 1 hit

Sequencei

Sequence statusi: Complete.

B8CRF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIKPRIRGF ICTTTHPVGC EANVLEQINI TKAKGKIANG PKKVLVVGSS
60 70 80 90 100
SGYGLSSRIT AAFGSDAATL GVFFEKPSSE TKPGTAGWYN SAAFDKFAKA
110 120 130 140 150
EGLYSKSINC DAFSHEAKQK AIELIKEDLG QVDMVVYSLA SPVRKLPDSG
160 170 180 190 200
ELIRSSLKPI GEPYKATAVD TNKDIIIEAS VEPATEQEIN DTVTVMGGED
210 220 230 240 250
WELWMQALAE AGVLADGCKT VAYSYIGTEL TWPIYWHGAL GKAKMDLDRA
260 270 280 290 300
AHALDDKLSA TGGSANVAVL KSVVTQASSA IPVMPLYIAM VFKKMRAEGL
310 320 330 340 350
HEGCIEQINR MFSERLYKAD GSAAEVDESN RLRLDDWELR EEIQQHCRDM
360 370 380 390 400
WPQVTSENLA ELTDYREYKE EFLKLFGFGI EGIDYEQDVN PNVEFDVVSI
Length:400
Mass (Da):43,915
Last modified:March 3, 2009 - v1
Checksum:i377DEC3ED313E4A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000472 Genomic DNA Translation: ACJ29960.1
RefSeqiWP_020913311.1, NC_011566.1

Genome annotation databases

EnsemblBacteriaiACJ29960; ACJ29960; swp_3256
KEGGiswp:swp_3256

Similar proteinsi

Entry informationi

Entry nameiFABV_SHEPW
AccessioniPrimary (citable) accession number: B8CRF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 3, 2009
Last modified: May 23, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health