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B8CR93 (B8CR93_SHEPW) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 2 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III 2 HAMAP MF_01815
Beta-ketoacyl-ACP synthase III 2 HAMAP MF_01815
Gene names
Name:fabH2 HAMAP MF_01815
Ordered Locus Names:swp_3047
OrganismShewanella piezotolerans (strain WP3 / JCM 13877) [Complete proteome] [HAMAP] EMBL ACJ29765.1
Taxonomic identifier225849 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region247 – 2515ACP-binding By similarity HAMAP MF_01815

Sites

Active site1121 By similarity HAMAP MF_01815
Active site2461 By similarity HAMAP MF_01815
Active site2761 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
B8CR93 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 4D899CC405E0799D

FASTA31933,928
        10         20         30         40         50         60 
MHTKILGTGS YLPVQVRSNQ DLEKMVETTV QWIVERTGIS ERRIAAADET VATMGYQAAV 

        70         80         90        100        110        120 
KAIEMAGIDA TEIDMIVCGT TSASNAFPAA ACEIQAMLGI HTIPAFDIAA ACSGFVYALS 

       130        140        150        160        170        180 
VADQYVKSGA ARNVLVIGAD VLSRLCEPED RSTIILFGDG AGAAVVGAAT EPGIISTHIY 

       190        200        210        220        230        240 
ADGRQGDLLK CSIPPRKGET SEAVGYMTMK GNDVFKVAVT QLSHVVTETL RQNNIEKSDI 

       250        260        270        280        290        300 
DWLVPHQANF RIIKATAKKL DMSLDKVVLT LAKHGNTSAA SVPIALDEAV RDGRIQRGQM 

       310 
ILLEAFGAGF AWGSALVKF

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References

[1]"Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3."
Wang F., Wang J., Jian H., Zhang B., Li S., Wang F., Zeng X., Gao L., Bartlett D.H., Yu J., Hu S., Xiao X.
PLoS ONE 3:E1937-E1937(2008) [PubMed: 18398463] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: WP3 EMBL ACJ29765.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000472 Genomic DNA. Translation: ACJ29765.1.
RefSeqYP_002312352.1. NC_011566.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB8CR93.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7034050.
GenomeReviewsGene locus swp_3047 in contig CP000472_GR.
KEGGswp:swp_3047.
PATRIC23544566. VBIShePie65056_2799.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMAFNAKEEA.
ProtClustDBPRK09352.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB8CR93_SHEPW
AccessionPrimary (citable) accession number: B8CR93
Entry history
Integrated into UniProtKB/TrEMBL: March 3, 2009
Last sequence update: March 3, 2009
Last modified: January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info