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B8CR83 (CDD_SHEPW) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytidine deaminase

EC=3.5.4.5
Alternative name(s):
Cytidine aminohydrolase
Short name=CDA
Gene names
Name:cdd
Ordered Locus Names:swp_3037
OrganismShewanella piezotolerans (strain WP3 / JCM 13877) [Complete proteome] [HAMAP]
Taxonomic identifier225849 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity. HAMAP-Rule MF_01558

Catalytic activity

Cytidine + H2O = uridine + NH3. HAMAP-Rule MF_01558

2'deoxycytidine + H2O = 2'-deoxyuridine + NH3. HAMAP-Rule MF_01558

Cofactor

Binds 1 zinc ion By similarity. HAMAP-Rule MF_01558

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01558

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Contains 1 CMP/dCMP deaminase zinc-binding domain.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functioncytidine deaminase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 296296Cytidine deaminase HAMAP-Rule MF_01558
PRO_1000147115

Regions

Domain59 – 13981CMP/dCMP deaminase zinc-binding
Region88 – 903Substrate binding By similarity

Sites

Active site1031Proton donor By similarity
Metal binding1011Zinc; catalytic By similarity
Metal binding1281Zinc; catalytic By similarity
Metal binding1311Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
B8CR83 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: B9DA5F5AA839FE5D

FASTA29632,292
        10         20         30         40         50         60 
MQDRFLKSIA NLPEALAKAI VPMLDKDFAG HLDAQQIEEL KTASQLTEQD LLLALLPIAA 

        70         80         90        100        110        120 
ALARVPISEF YVGAIAKGKS GDIYMGANLE LAGEALFHSV HAEQSAISHA WLSGERQIED 

       130        140        150        160        170        180 
VIVNFSPCGH CRQFMNELVE GQKVNIHLPE QKTQPLSHYL PYAFGPGDLN ITEPLLTKQQ 

       190        200        210        220        230        240 
HELSLDSSDP MIIEAVDHAG LSYAPYTKNY AAVVLETKDG VTYSGRYAEN AAFNPSMLPM 

       250        260        270        280        290 
QMALSNMARH NRDFSEINRA VLIESSKGSV SLVGATMDAL HAVAAVELEH IVVESE 

« Hide

References

[1]"Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3."
Wang F., Wang J., Jian H., Zhang B., Li S., Wang F., Zeng X., Gao L., Bartlett D.H., Yu J., Hu S., Xiao X.
PLoS ONE 3:E1937-E1937(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WP3 / JCM 13877.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000472 Genomic DNA. Translation: ACJ29755.1.
RefSeqYP_002312342.1. NC_011566.1.

3D structure databases

ProteinModelPortalB8CR83.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING225849.swp_3037.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACJ29755; ACJ29755; swp_3037.
GeneID7034040.
KEGGswp:swp_3037.
PATRIC23544548. VBIShePie65056_2790.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0295.
HOGENOMHOG000218617.
KOK01489.
OMANRSHAPY.
OrthoDBEOG6XDH25.
ProtClustDBPRK09027.

Enzyme and pathway databases

BioCycSPIE225849:GH6V-2971-MONOMER.

Family and domain databases

HAMAPMF_01558. Cyt_deam.
InterProIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR013171. Cyd/dCyd_deaminase_Zn-bd.
IPR006263. Cyt_deam_dimer.
IPR016193. Cytidine_deaminase-like.
IPR020797. Cytidine_deaminase_bacteria.
[Graphical view]
PfamPF00383. dCMP_cyt_deam_1. 1 hit.
PF08211. dCMP_cyt_deam_2. 1 hit.
[Graphical view]
PIRSFPIRSF006334. Cdd_plus_pseudo. 1 hit.
SUPFAMSSF53927. SSF53927. 2 hits.
PROSITEPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDD_SHEPW
AccessionPrimary (citable) accession number: B8CR83
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: February 19, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families