Reviewed, UniProtKB/Swiss-Prot B8CR83 (CDD_SHEPW)

Names and origin

Protein names

Recommended name:
    Cytidine deaminase
    EC=3.5.4.5
Alternative name(s):
    Cytidine aminohydrolase
      Short name=CDA

Gene names

Name:	cdd
Ordered Locus Names:	swp_3037

Organism

Shewanella piezotolerans (strain WP3 / JCM 13877) [Complete proteome] [HAMAP]

Taxonomic identifier

225849 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.
Catalytic activity	Cytidine + H2O = uridine + NH3. HAMAP MF_01558
Cofactor	Binds 1 zinc ion By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Cytidine deaminase HAMAP MF_01558		PRO_1000147115
Regions
	Region	88 – 90	3	Substrate binding By similarity
Sites
	Active site	103	1	Proton donor By similarity
	Metal binding	101	1	Zinc; catalytic By similarity
	Metal binding	128	1	Zinc; catalytic By similarity
	Metal binding	131	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	B8CR83-1 [UniParc]. Last modified March 3, 2009. Version 1. Checksum: B9DA5F5AA839FE5D	FASTA	296	32,292
	10 20 30 40 50 60 MQDRFLKSIA NLPEALAKAI VPMLDKDFAG HLDAQQIEEL KTASQLTEQD LLLALLPIAA 70 80 90 100 110 120 ALARVPISEF YVGAIAKGKS GDIYMGANLE LAGEALFHSV HAEQSAISHA WLSGERQIED 130 140 150 160 170 180 VIVNFSPCGH CRQFMNELVE GQKVNIHLPE QKTQPLSHYL PYAFGPGDLN ITEPLLTKQQ 190 200 210 220 230 240 HELSLDSSDP MIIEAVDHAG LSYAPYTKNY AAVVLETKDG VTYSGRYAEN AAFNPSMLPM 250 260 270 280 290 QMALSNMARH NRDFSEINRA VLIESSKGSV SLVGATMDAL HAVAAVELEH IVVESE

References

[1]

"Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3." Wang F., Wang J., Jian H., Zhang B., Li S., Wang F., Zeng X., Gao L., Bartlett D.H., Yu J., Hu S., Xiao X. PLoS ONE 3:E1937-E1937(2008) [PubMed: 18398463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000472 Genomic DNA. Translation: ACJ29755.1.
RefSeq	YP_002312342.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	7034040.
GenomeReviews	Gene locus swp_3037 in contig CP000472_GR.
KEGG	swp:swp_3037.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_01558. [Tree]
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn_bd. IPR013171. Cyd/dCyd_deaminase_Zn_bd. [Graphical view]
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. PF08211. dCMP_cyt_deam_2. 1 hit. [Graphical view]
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_SHEPW

Accession

Primary (citable) accession number: B8CR83

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	March 3, 2009
Last modified:	October 13, 2009
This is version 7 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)