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B8CR70 (SPEA_SHEPW) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:swp_3024
OrganismShewanella piezotolerans (strain WP3 / JCM 13877) [Complete proteome] [HAMAP]
Taxonomic identifier225849 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length637 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 637637Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_1000145603

Regions

Region286 – 29611Substrate-binding Potential

Amino acid modifications

Modified residue1011N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B8CR70 [UniParc].

Last modified March 3, 2009. Version 1.
Checksum: 049210A3D93B1F27

FASTA63771,415
        10         20         30         40         50         60 
MNNWSIDDAR ASYNVNYWSQ GLYGISDEGE VTVSPDPNRP DCKIGLNELA KDMVKAGVAL 

        70         80         90        100        110        120 
PVLVRFPQIL HHRVNSLCQA FNQAIQKYKY EADYLLVYPI KVNQQQTVVE EILASQVEKE 

       130        140        150        160        170        180 
VPQLGLEAGS KPELLAVLAM AQKASSVIIC NGYKDKEYIR LALIGEKLGH KVYIVLEKMS 

       190        200        210        220        230        240 
ELKVVLEQAK ELGVTPRLGL RVRLAFQGKG KWQASGGEKS KFGLSAAQVL KVIELLQHEE 

       250        260        270        280        290        300 
MLDSLELLHF HLGSQIANIR DIRQGVSEAG RFYCELMKLG AQVKCFDVGG GLAVDYDGTR 

       310        320        330        340        350        360 
SQSNNSMNYG LTEYANNIVS VLTDMCKEYE QPMPRIISES GRYLTAHHAV LLTDVIGTES 

       370        380        390        400        410        420 
YKPETILPPS EDAPLLLQNM WQSWTEVSGK ADQRALIEIF HDCQSDLTEV HSLFALGQLS 

       430        440        450        460        470        480 
LADRAWAEQI NLRVCHELQG SMSSKYRYHR PIIDELNEKL ADKFFVNFSL FQSLPDAWGI 

       490        500        510        520        530        540 
DQVFPVMPLS GLDKAPERRA VMLDITCDSD GIVDQYVDGQ GIETTLPVPA WTQESPYLIG 

       550        560        570        580        590        600 
FFLVGAYQEI LGDMHNLFGD TNSAVVRVDE NGRRNIDSVL EGDTVADVLR YVNLEAVSFM 

       610        620        630 
RTYEELVNKH IVADERSNIL EELQLGLKGY TYLEDFS 

« Hide

References

[1]"Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3."
Wang F., Wang J., Jian H., Zhang B., Li S., Wang F., Zeng X., Gao L., Bartlett D.H., Yu J., Hu S., Xiao X.
PLoS ONE 3:E1937-E1937(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: WP3 / JCM 13877.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000472 Genomic DNA. Translation: ACJ29742.1.
RefSeqYP_002312329.1. NC_011566.1.

3D structure databases

ProteinModelPortalB8CR70.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING225849.swp_3024.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACJ29742; ACJ29742; swp_3024.
GeneID7034027.
KEGGswp:swp_3024.
PATRIC23544528. VBIShePie65056_2780.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OMAIDHYVDG.
OrthoDBEOG676Z0R.

Enzyme and pathway databases

BioCycSPIE225849:GH6V-2958-MONOMER.
UniPathwayUPA00186; UER00284.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR01273. speA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSPEA_SHEPW
AccessionPrimary (citable) accession number: B8CR70
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways